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The incidence of treatment-related neuroendocrine prostate cancer (t-NEPC) is rising as more potent drugs targeting the androgen signaling axis are clinically implemented. Neuroendocrine transdifferentiation (NEtD), an putative initial step in t-NEPC development, is induced by androgen-deprivation therapy (ADT) or anti-androgens, and by activation of the β2-adrenergic receptor (ADRB2) in prostate

Black hole binary systems with companion stars are typically found via their x-ray emission, generated by interaction and accretion. Noninteracting binaries are expected to be plentiful in the Galaxy but must be observed using other methods. We combine radial velocity and photometric variability data to show that the bright, rapidly rotating giant star 2MASS J05215658+4359220 is in a binary system

Brettanomyces naardenensis is a spoilage yeast with potential for biotechnological applications for production of innovative beverages with low alcohol content and high attenuation degree. Here, we present the first annotated genome of B. naardenensis CBS 7540. The genome of B. naardenensis CBS 7540 was assembled into 76 contigs, totaling 11,283,072 nucleotides. In total, 5168 protein-coding seque

PurposeThe aim of the present study was to identify the most physically demanding work tasks for Swedish ground combat soldiers through the development and application of a questionnaire survey. This is the first in a series of studies aiming to describe the development process and validation of physical selection standards in the Swedish armed forces.MethodsBased on procedural documentation, comb

Gas-liquid mass transfer in wastewater treatment processes has received considerable attention over the last decades from both academia and industry. Indeed, improvements in modelling gas-liquid mass transfer can bring huge benefits in terms of reaction rates, plant energy expenditure, acid-base equilibria and greenhouse gas emissions. Despite these efforts, there is still no universally valid cor

Huntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer from a spectrum of non-motor features often decades before the motor disorder manifests. These sy

The presence of many completely uncharacterized proteins, even in well-studied organisms such as humans, seriously hampers a full understanding of the functioning of living cells. One such example is the human protein C12ORF4, which belongs to the DUF2362 family, present in many eukaryotic lineages and conserved in metazoans. The only functional information available on C12ORF4 (Chromosome 12 Open

Co-housing is an emerging housing form in Spain, where many pioneering initiatives are found in Catalonia and the Barcelona area. Using the La Borda project as a recurring illustration, but also drawing on other examples and developments, the chapter seeks to contextualize this nascent but noticeable interest in co-housing in and around Barcelona. Starting at the scale of the crisis-ridden Spanish

This chapter looks at the interrelations and dynamics between urban activism and the politics of co-housing. Drawing on empirical material from Hamburg and Barcelona, it explores the socio-political context of co-housing in the interplay of bottom-up organizing and top-down governance. With particular attention to squatting and related questions of post-autonomous urban activism, this investigatio

Co-housing is often lauded as an alternative housing form offering a more socially, ecologically and economically sustainable way of living. This book takes its departure in the need for a critical exploration of co-housing in the context of sustainable urban development, beyond the normative approach that often characterizes co-housing research. Based on a four-year research project involving in-

In this conclusion we argue that, while we have demonstrated in this book that definitions of co-housing as well as co-housing practices in different European countries vary, there are some general lessons to be learned for anyone interested in understanding or practising co-housing in the context of advanced capitalist societies. This conclusion has three parts: First, we address the questions as

We conduct a contest experiment to study if spread seeking and effort can be managed when participants can invest in increasing both the mean and the spread of an uncertain performance variable. Subjects are treated with different prize schemes and in accordance with theory, we observe higher investments in spread for the winner-take-all scheme. Both types of investments can be controlled with a t

Background: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. Tumourinfiltrating immune cells are vital in shaping the natural progress of canBackground: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. Tumourinfiltrating immune cells are vital in shaping the natural progress of can

The ultimate goal of studies on microbial adhesion is to understand what molecular interactions between the host and microbe occur in vivo and the impact of these interactions on disease processes. With this goal in mind, the problem can be approached at four levels. At the biochemical level, the host receptors at the relevant colonization site are identified; at the cell biology level, consequenc