Biological activities of novel Platelet-derived growth factors, PDGF-C and PDGF-D
Platelet-derived growth factors (PDGFs) belong to the PDGF/VEGF (vascular endothelial growth factor) family of growth factors. Members of this family share a common structural feature, a conserved PDGF/VEGF homology domain, containing eight invariant cysteine residues. PDGFs form disulphidelinked dimers and exert their biological functions by binding to, and activating two receptor tyrosine kinase