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In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research over the last 10 years, and the introduction of novel therapies such as targeted therapies and immunomodulators, the rather dark horizon of the median survival has dramatically changed from under 1 year to several years. With the advent of proteomics, deep-mining studies can reac
Climate changes induce warmer climate with stronger and more frequent extreme events. Due to the uncertain nature of climate, accurate simulation of future conditions is impossible and a major challenge is the selection of climate data in the impact assessment. This work compares application of three climate data sets in an energy simulation of the EPFL campus: i) Regional Climate Models (RCM data
Massively parallel DNA sequencing opens up opportunities for bridging multiple temporal and spatial dimensions in biodiversity research, thanks to its efficiency to recover millions of nucleotide polymorphisms. Here, we identify the current status, discuss the main challenges, and look into future perspectives on biodiversity genomics focusing on insects, which arguably constitute the most diverse
Atria are implemented in buildings to increase daylight, foster interaction and provide ventilation. However, their implementation can be complex if good daylight is to be achieved. This research proposed an investigation about the atrium parameters that affect daylight conditions in a case study. This evaluation concentrated in the atrium geometry and the wall reflectance values. Overall, the out
Focusing on subjective evaluations of daylight conditions, the present paper explores the relation between room geometric characteristics and perceived brightness and daylight distribution in residential spaces. The study was conducted in 35 apartments consisting of 105 different rooms in the city of Malmö, and selected with respect to typical Swedish architectural building typologies. Questionnai
Brachylaena discolor (Asteraceae) is a medicinal plant used in Mozambique to treat stomachache, tuberculosis, and diabetes. To discover new lead compounds with leishmanicidal activity, a methanolic extract of the leaves of this plant was investigated. Through fractionation, employing several chromatographic methods, two sesquiterpene lactones onopordopicrin (1) and its germacronolide epoxide deriv
Romulus Bucur is a renowned writer and literary critic. He is also faculty member at Transylvania University of Brasov, institution well-known for its courses of creative writing and translation studies. "Glosses" is a nimbly written theoretical book wherein many topics are analyzed. One of the most important is the work of Alexandru Musina, editor, writer, professor, and mentor of the Group of Br
BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. Another aim was to assess how dose reductions and treatme
Many everyday interactions with moving objects benefit from an accurate perception of their movement. Self-motion, however, complicates object motion perception because it generates a global pattern of motion on the observer's retina and radically influences an object's retinal motion. There is strong evidence that the brain compensates by suppressing the retinal motion due to self-motion, however
Background and purpose — Hip arthroplasty is one of the most performed surgeries in Sweden, and the rate of adverse events (AEs) is fairly high. All patients in publicly financed healthcare in Sweden are insured by the Mutual Insurance Company of Swedish County Councils (Löf). We assessed the proportion of patients that sustained a major preventable AE and filed an AE claim to Löf. Patients and me
In a piloted jet flame, the pilot flame has an effect of stabilizing the main flame. Detailed mechanisms of pilot flame/main flame interaction are however not well studied. It is expected that the pilot flame affects the main flame through the following mechanisms: (a) the pilot flame provides the heat and radicals to the reaction zone of the main flame, (b) the pilot flame prevents the cold ambie
Introduction: For fast and effective antibiotic therapy of serious infections like sepsis, it is crucial with rapid information about antibiotic susceptibility, especially in a time when the number of infections caused by multi resistant bacteria has escalated in the world. Methods: Here, we have used a semi-quantitative MALDI-TOF-MS based method for antibiotic resistance detection, MBT-ASTRA™, wh
Purpose: Comorbidity in stroke is common, but comprehensive reports are sparse. We describe prevalence of comorbidity and the prognostic impact on mortality and functional outcome in a large national ischemic stroke cohort. Methods: We used outcome data from a long-term follow-up survey conducted in 2016 by the Swedish Stroke Register (Riksstroke). Those included in the study were 11 775 pre-strok
