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Structure and scalar correlation of ammonia/air turbulent premixed flames in the distributed reaction zone regime

Instantaneous structures of turbulent premixed ammonia/air flames on a piloted jet burner were investigated using simultaneous planar laser-induced fluorescence (PLIF) and Rayleigh thermometry measurements. Two-dimensional spatial distributions of temperature were simultaneously measured with those of the NH radical and the NO pollutant, respectively. Experiments were conducted for stoichiometric

Using Action Design Research for Developing and Implementing a Method for Risk Assessment and Continuity Management

This paper presents the results from a longitudinal study aiming at developing and implementing a method integrating principles from Risk Management and Business Continuity Management in its naturalistic organisational setting. Despite the fact that a myriad of real-world constraints and challenges typically arise in the transition from method development to full implementation and use of the meth

Addressing Structural Secrecy as a Way of Nurturing Resilient Performance

Structural secrecy refers to a systematic undermining of attempts to know and interpret situations in organisations, which significantly challenges their abilities to perform resiliently. In this chapter, we briefly share some insights drawn from a collaboration with the municipality of Malmö, Sweden, for a period of more than three years that has provided knowledge about the needs and constraints

Review of life science applications using submicron O-PTIR and simultaneous Raman microscopy: a new paradigm in vibrational spectroscopy

The recent advent of Optical Photothermal IR (O-PTIR), has enabled for the first time, submicron infrared microscopy in far-field reflection mode with the combination of Raman for simultaneous, correlative IR+Raman microscopy. These unique and exciting synergistic capabilities are now spawning interest in life science application. A broad range of life science applications, otherwise impossible wi

Adverse outcomes in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors : Follow-up of patients diagnosed 2002–2017 in a complete coverage and nationwide agnostic register study

Tyrosine kinase inhibitors (TKIs) have profoundly improved the clinical outcome for patients with chronic myeloid leukemia (CML), but their overall survival is still subnormal and the treatment is associated with adverse events. In a large cohort-study, we assessed the morbidity in 1328 Swedish CML chronic phase patients diagnosed 2002–2017 and treated with TKIs, as compared to that in carefully m

Evolving cellular automata schemes for protein folding modeling using the Rosetta atomic representation

Protein folding is the dynamic process by which a protein folds into its final native structure. This is different to the traditional problem of the prediction of the final protein structure, since it requires a modeling of how protein components interact over time to obtain the final folded structure. In this study we test whether a model of the folding process can be obtained exclusively through

Research status of supercritical aviation kerosene and a convection heat transfer considering thermal pyrolysis

Purpose: This paper aims to comprehensively clarify the research status of thermal transport of supercritical aviation kerosene, with particular interests in the effect of cracking on heat transfer. Design/methodology/approach: A brief review of current research on supercritical aviation kerosene is presented in views of the surrogate model of hydrocarbon fuels, chemical cracking mechanism of hydr

Validation of Patient Identification Algorithms for Atopic Dermatitis Using Healthcare Databases

Introduction: The use of real-world data offers a possibility to perform large-scale epidemiological studies in actual clinical settings. Despite their many advantages, administrative databases were not designed to be used in research, and the validation of diagnoses and treatments in administrative databases is needed. The primary objective of this study was to validate an existing algorithm base

Splitting the sexes : The birth and senescence of sex chromosomes

The evolution of gonochorism from hermaphroditism can be gradual by increasing investment in one sex role while decreasing in the other, or rapid through the fixation of sex-role sterility mutations, eventually leading to the evolution of sex chromosomes. It is expected that the transition will involve a temporary state of gynodioecy or androdioecy as the mutations are not expected to take place a

Host Immunity-Microbiota-Virus Interactions at the Intestinal Mucosal surface in Health and Disease

The presence of viral immune triggers at the intestinal mucosa can have multipleglobal effects on intestinal integrity, including relative protection fromsubsequent inflammatory bowel disease. During the last century, the westernworld has achieved a remarkable success in preventing infectious diseases,which increased the general life expectancy dramatically. However, theincidence and prevalence of

Match length realization and cooperation in indefinitely repeated games

Experimental studies of infinitely repeated games typically consist of several indefinitely repeated games (“matches”) played in sequence with different partners each time, whereby match length, i.e. the number of stages of each game is randomly determined. Using a large meta data set on indefinitely repeated prisoner's dilemma games (Dal Bó and Fréchette, 2018) we demonstrate that the realized le

Circular business models for the fastmoving consumer goods industry : Desirability, feasibility, and viability

Fast-moving consumer goods (FMCGs) are products that have a short useful lifetime and are typically designed for single or limited uses followed by disposal. The disposable nature of FMCGs combined with ineffective waste recovery systems is causing global environmental problems. Various reusable packaging business models have emerged to tackle these problems; however, their influence is still low

Mother's Own Milk and Its Relationship to Growth and Morbidity in a Population-based Cohort of Extremely Preterm Infants

Objectives:The aim of the study was to evaluate the relationships between intake of mother's own milk (MOM), compared with intake of pasteurized donor milk (DM), and postnatal growth, incidence of retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD), in extremely preterm infants.Methods:Swedish population-based cohort of surviving extremely preterm infants born 2004 to 2007. Expos

Paediatric diagnostic reference levels for common radiological examinations using the European guidelines

Objective: The purpose of this study was to explore the feasibility to determine regional diagnostic reference levels (RDRLs) for paediatric conventional and CT examinations using the European guidelines and to compare RDRLs derived from weight and age groups, respectively. Methods: Data were collected from 31 hospitals in 4 countries, for 7 examination types for a total of 2978 patients. RDRLs we

Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences : A multivariate meta-analysis

Mitochondria are maternally inherited organelles that play critical tissue-specific roles, including hormone synthesis and energy production, that influence human development, health, and aging. However, whether mitochondria from women and men exhibit consistent biological differences remains unclear, representing a major gap in knowledge. This meta-analysis systematically examined four domains an

A Palette of Fluorescent Aβ42 Peptides Labelled at a Range of Surface-Exposed Sites

Fluorescence-based single molecule techniques provide important tools towards understanding the molecular mechanism of complex neurodegenerative diseases. This requires efficient covalent attachment of fluorophores. Here we create a series of cysteine mutants (S8C, Y10C, S26C, V40C, and A42C) of Aβ42, involved in Alzheimer’s disease, based on exposed positions in the fibril structure and label the

Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation

AIM: This study investigated childhood diagnoses in children born extremely preterm before 24 weeks of gestation.METHODS: Diagnoses of neurodevelopmental disorders and selected somatic diagnoses were retrospectively retrieved from national Swedish registries for children born before 24 weeks from 2007 to 2018. Their individual medical files were also examined.RESULTS: We studied 383 children born

Climate change and land degradation in Africa : A case study in the Mount Elgon region, Uganda

The aim of this study is to estimate and compare soil erosion, in the Mount Elgon region, eastern Uganda, during the last decade. Possible trends and changes in erosion are linked to precipitation/climate change as well as changes in land cover. Two different versions of the Revised Universal Soil loss Equation RUSLE. are implemented and compared, one using slope length and the other using flow ac

Estimating surface flow over digital elevation models using a new improved form-based algorithm

This paper discusses new improvements of a form-based algorithm, which is used to estimate flow distribution over a continuous surface. In the new form- based algorithm (IFBFD), cells in a DEM are classified into five different classes. The classes are Peaks, Complicated, Sinks, Flats and Undisturbed cells. The method of how to estimate the flow distribution from each cell depends on its class. Es