This thesis concerns the nature of cognition. It posits that cognitive processes primarily are means to maintain allostasis in organisms whose ecological niches require movement to approach food-resources and avoid predation. Hence triggering, or motivation, of behaviours are a consequence of prediction errors from the body resulting from biological variables moving away from homeostasis. Dependin

Denna artikel innehåller en analys av samtliga rapporter från Statens offentliga utredningar (SOU), 1945-89. Analysen applicerar metoder inom digital humaniora och inkluderar forskning gjort i en Jupyterlabbmiljö som utvecklats på Humlab på Umeå universitet. Artikeln är ett resultat av forskningsprojektet Välfärdsstaten analyserad, som ämnar att digitalisera litteratur, arbetar med datasäkring av In 2015 the National Library of Sweden finished digitising all Governmental Official Reports (SOU) from 1922 to 1999. Traditionally, SOU reports – and work performed within different governmental committees – were tasked with preparing the Swedish government for apt and rational decision-making. The range of subjects covered by governmental committees and SOU reports basically includes every area

Kommuner och deras invånare möter nya utmaningar till följd av ett förändrat klimat.Översvämningar, värmeböljor och stormar förväntas öka i antal och styrka, medan processer som havshöjning och erosion hotar att radikalt omskapa lokala samhällen och landskap. Dessutom kan nuvarande ansvarsförhållanden komma att omdanas då klimateffekterna överstiger kommuners mandat eller kapacitet. Allt högre kra

The medial temporal lobe (MTL) is connected to the rest of the brain through two main networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the crucial role of the MTL and networks in the physiopathology of Alzheimer's disease (AD), the present study aimed at (1) investigating whether MTL atrophy propagates specifically within the AT and PM networks, and (2) evaluating

INTRODUCTION: Drug-resistant epilepsy patients show worse outcomes after resection when standard neuroimaging is nonlesional, which occurs in one-third of patients. In prior work, we employed 2-D glutamate imaging, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to lateralize seizure onset in nonlesional temporal lobe epilepsy (TLE) based on increased ipsilateral GluCEST signal in the t

INTRODUCTION: It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).METHODS: We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of ta

We demonstrate a successful process scheme for the integration of a CMOS-compatible ferroelectric gate stack on a scaled vertical InAs nanowire gate-all-around MOSFET on silicon. The devices show promising device characteristics with nanosecond write time and large memory window of >1.5 V. In the current implementation, the device performance is mainly limited by access resistance, which is attrib

As a result of recent research discoveries and technological advancements within neuroscience, a growing interest in the brain and its functions permeates not only film studies, but also the field of humanities as a whole. Yet, the neuroscientific influence on contemporary film studies is not easily defined; on the contrary, film scholars with different starting points identify fundamentally diver

This report presents tools for post-occupancy evaluation (POE) to evaluate indoor lighting of commissioned projects (‘case studies’) under a common framework. In this report, POE includes technical environmental assessment (TEA) and observer-based environmental assessment (OBEA). The framework proposed in this report evaluates four key aspects of the case study:1. Energy use (electrical lighting s

This paper focuses on recent debates between the proponents of individualismand communitarianism. As the authors argue, the dichotomous character ofthese debates is inherently problematic, as no one functions just as an individualor member. Starting from the discussion around the Netflix series "Unorthodox"in the Swedish context, the authors engage with Sharon Todd’s radical conception of pluralit

Most creatives acquire professional talents by learning from others, but in most settings it is difficult to estimate the existence of long-term effects. This paper explores the transmission of skills over a period of more than seven centuries by focusing on the case of music composers. We ask the question: how does a composer’s quality influence the quality of the composers he or she teaches? Our

Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofactor-bound forms, key information is missing due to technical limitations, including (a) the location

Sustainability footprints are caused by semiconductor malfunctioning; production challenges (low yield) and customer returns (wear-out). We work with standards, techniques, and methods to quickly and accurately pin-point and mitigate malfunctioning aiming at graceful degradation to prolong operational lifetime.

Denna artikel diskuterar arkivkällor med känslig information och behovet av olika etiska angreppssätt. Avsikten med att lyfta dessa frågor är att frambringa en diskussion om hur historiker kan arbeta med känsligt material på ett etiskt sätt. Artikeln lyfter fram främst tre begrepp: processetik, omsorgsetik och dygdetik.In comparison to disciplines within the humanities and social sciences working directly with living humans, as well as in comparison to oral history, historians primarily working with archival sources lack a living discussion on ethics in connection with our methods. At the same time, archival sources that contain sensitive personal information are central in many fields – such as queer history –

Background: Smoking cessation may be very difficult, even if smoking aggravates the prognosis of a disease, which has been shown to be the case for persons with rheumatoid arthritis (RA). In contrast, an association in patients with osteoarthritis (OA) is still disputed. The primary objective was to compare smokers diagnosed with RA and OA to controls, regarding smoking cessation rates after follo