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Sedimentology of the Lower Ordovician (upper Tremadocian) Bjørkåsholmen Formation at Flagabro, southern Sweden

The Lower Ordovician Bjørkåsholmen Formation at Flagabro, Scania, southern Sweden, consists of a 0.8 m thick succession of carbonates with three siliciclastic mudstones, 5, 1 and 100 mm thick, intercalated in the central part of the unit. Carbonate and siliciclastic mudstone beds show both normal and inverse grading. The carbonates are mud-rich and subdivided into a mudstone, a wackestone and a pa

Interleukin-25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice

Atherosclerosis is a chronic inflammatory disease characterized by the entrapment of apolipoprotein B– containing lipoproteins in the arterial intima, leading to local inflammation. T helper (Th) cell 1–mediated immune responses have been associated with atherosclerosis, and the cytokine interleukin-25 (IL-25 or IL-17E) has been reported to potentially regulate Th1 cell– and Th17 cell–related immu

Chest-lead ST-J amplitudes using arm electrodes as reference instead of the Wilson central terminal in smartphone ECG applications : Influence on ST-elevation myocardial infarction criteria fulfillment

Background: "Smartphone 12-lead ECG" for the assessment of acute myocardial ischemia has recently been introduced. In the smartphone 12-lead ECG either the right or the left arm can be used as reference for the chest electrodes instead of the Wilson central terminal. These leads are labeled "CR leads" or "CL leads." We aimed to compare chest-lead ST-J amplitudes, using either CR or CL leads, to th

Physiological adaptation of the growth-restricted fetus

The growth-restricted fetus in utero is exposed to a hostile environment and suffers undernutrition and hypoxia. To cope with the stress, the fetus changes its physiological functions. These adaptive changes aid intrauterine survival; however, they can lead to permanent functional and structural changes that can contribute to the development of serious chronic diseases later in life. Epigenetic me

Can the narrow red bands of dragonflies be used to perceive wing interference patterns?

Despite numerous studies of selection on position and number of spectral vision bands, explanations to the function of narrow spectral bands are lacking. We investigate dragonflies (Odonata), which have the narrowest spectral bands reported, in order to investigate what features these narrow spectral bands may be used to perceive. We address whether it is likely that narrow red bands can be used t

The pericyte secretome : Potential impact on regeneration

Personalized and regenerative medicine is an emerging therapeutic strategy that is based on cell biology and biomedical engineering used to develop biological substitutes to maintain normal function or restore damaged tissues and organs. The secretory capacities of different cell types are now explored as such possible therapeutic regenerative agents in a variety of diseases. A secretome can compr

Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia

Fluid biomarkers, including cerebrospinal fluid (CSF) biomarkers and blood-based biomarkers, may reflect different pathological processes in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The most used biomarkers are CSF β-amyloid42, total tau, phosphorylated tau, and neurofilament light, which have been studied for diagnosis, prognosis, and treatment follow-up and in relation to gene

Protein biomarkers associated with pain mechanisms in osteoarthritis

Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. OA pain is multifactorial and may arise from multiple distinct or concurrent mechanisms, and may thus present as

Levels of DNA damage (Micronuclei) in patients suffering from chronic kidney disease. Role of GST polymorphisms

Chronic kidney disease (CKD) patients are characterized by the presence of high levels of DNA damage, and a poor response to ionizing radiation. In this study, we proposed that variants in GST genes could explain this fact. One-hundred twenty seven CKD patients and one-hundred forty five controls constituted the studied groups. Micronuclei (MN) frequency was determined in peripheral blood lymphocy

Alcohol Availability and Onset and Recurrence of Alcohol Use Disorder : Examination in a Longitudinal Cohort with Cosibling Analysis

Background: Recent reviews of associations of alcohol availability with alcohol outcomes suggest findings are highly inconsistent and highlight a lack of longitudinal and causal evidence. Effect modification (moderation or statistical interaction), which could contribute to the inconsistent picture in the existing literature, has not been systematically assessed. We examined associations of alcoho

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The editing process to which Svetlana Alexievich subjects her texts has repeatedly been cause for criticism. Her treatment of the documentary material does not stand up to a critical assessment of her sources. However, this approach is closely linked to the core of the message in her books: memories and feelings demand forms other than objective facts. Alexievich's successive re-workings reduce th

The identification of discontinuous epitope in the human cystatin C – Monoclonal antibody HCC3 complex

Human cystatin C (hCC) is a cysteine proteinase inhibitor involved in pathophysiological processes of dimerization and amyloid formation. These processes are directly associated with a number of neurodegenerative disorders such as Alzheimer disease or hereditary cystatin C amyloid angiopathy (HCCAA). One of the ideas on how to prevent amyloid formation is to use immunotherapy. HCC3 is one of a gro

Decline of HPV infections in Scandinavian cervical screening populations after introduction of HPV vaccination programs

Objective: To monitor the changes in prevalence of human papillomavirus (HPV) infections in women 12,000 women participating in cervical screening in the 3 Nordic countries before and after introduction of organized qHPV vaccination demonstrated a marked decline in HPV infection in the younger population in the 2 countries where qHPV vaccination programs started in 2008–2009, suggesting that organ

Synthesis and molecular structures of the 52-electron triiron telluride clusters [Fe3(CO)83-Te)22-diphosphine)] - Electrochemical properties and activity as proton reduction catalysts

Heating the 50-electron cluster [Fe3(CO)9 (μ3-Te)2] (1) with the diphosphines Ph2P-R-PPh2 [R = -CH2CH2- (dppe), Z-CH=CH- (dppv), 1,2-C6H4 (dppb), -CH2CH2CH2- (dpp), ferrocenyl (dppf), naphthalenyl (dppbn)] in benzene affords the 52-electron diphosphine-containing tellurium-capped triiron clusters [Fe3(CO)8 (μ3-Te)2 (κ2-diphosphine)] (diphosphine = dppe, dppv, dppb, dpp, dppf, dppnd) (2–7) in moder

Trabecular bone texture detected by plain radiography is associated with MRI-defined osteophytes in finger joints of women without radiographic osteoarthritis

Objective: To examine associations between trabecular bone (TB) texture and magnetic resonance imaging (MRI)-defined osteophytes in finger joints without radiographic osteoarthritis (OA) using an augmented variance orientation transform (AVOT) method. Design: In a cross-sectional study, associations of the TB texture and osteophytes were examined in 21 women with mean (standard deviation) age of 6

High-resolution δ13Corg chemostratigraphy links the Decorah impact structure and Winneshiek Konservat-Lagerstätte to the Darriwilian (Middle Ordovician) global peak influx of meteorites

The precise age of the Winneshiek Shale, a recently discovered Konservat-Lagerstätte located in a very unusual depositional setting inside the Decorah impact structure, has remained uncertain in the absence of biostratigraphically highly diagnostic fossils. This chemostratigraphical study, based on δ13Corg data from 36 drill core samples through the shale, shows that the age ranges from the upper