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Fluid biomarkers are revolutionizing the diagnosis and management of neurodegenerative diseases by enabling earlier diagnosis and disease monitoring. In particular, blood-based biomarkers have emerged as a minimally invasive and scalable alternative to cerebrospinal fluid analysis. Recent advances in blood-based tau biomarkers have shown high diagnostic accuracy for Alzheimer’s disease (AD). Other
PURPOSE OF REVIEW: The purpose of this study was to review public and private sector obesity policies in Canada and to make recommendations for future evidence-based obesity prevention and management strategies.RECENT FINDINGS: Synthesis of obesity prevention and management policies and research studies are presented in three primary themes: (1) Increased awareness about the impact of weight bias
OBJECTIVES: Public health policies have been criticized for promoting a simplistic narrative that may contribute to weight bias. Weight bias can impact population health by increasing morbidity and mortality. The objectives of this study were to: 1) critically analyze Canadian obesity prevention policies and strategies to identify underlying dominant narratives; 2) deconstruct dominant narratives
Neuroinflammation emerges as a central driver of neurodegeneration, yet the molecular regulators orchestrating pathological microglial activation remain incompletely understood. This thesis investigates galectin-3 (Gal3), a glycan-binding protein with dual roles in microglial homeostasis and inflammatory signaling, as a master regulator linking neuroinflammation to proteinopathy progression in Alz
Fibrillarin (FBL), a core component of the C/D box small nucleolar ribonucleoprotein (snoRNP) complex, catalyzes the 2′-O-methylation (Nm) of the ribose 2′-hydroxyl moiety in ribosomal RNA (rRNA). Distinct Nm patterns contribute to ribosome heterogeneity, which is linked to selective translation of oncogenes. FBL dysregulation generates an aberrant Nm signature in triple-negative breast cancer (TN
This thesis examines whether international law is sufficiently equipped for a sound conceptualization of migrants’ and refugees’ right to access housing beyond a minimalistic paradigm. Itaims to assess the potential and shortcomings of this right in counteracting the manner in which power is exercised in migration law, policy, and politics to instrumentalize housing against migrants and refugees. This thesis examines whether international law is sufficiently equipped for a sound conceptualization of migrants’ and refugees’ right to access housing beyond a minimalistic paradigm. Itaims to assess the potential and shortcomings of this right in counteracting the manner in which power is exercised in migration law, policy, and politics to instrumentalize housing against migrants and refugees.
Introduction: The co-occurrence of lupus nephritis (LN) and chronic kidney disease (CKD) is associated with an excess risk of infection. However, it remains unknown whether the infection risk differs between LN with moderate and advanced CKD (LN-CKD) and other CKD etiologies. Methods: Using data from the Swedish Renal registry 2006-2021, we identified 14,128 patients (median age 68 years, 64% men,
Background: This study aimed to investigate the relevance of various predictors of mortality in late life. Additionally, it explored whether mental health indicators such as depressive symptoms, and cognitive ability, which are known predictors of healthy ageing, are also important markers of mortality. By examining both physical and mental health indicators, we aimed to gain a more comprehensive
OBJECTIVE: A previous placebo-controlled crossover study of intratympanic latanoprost-a drug commonly used for glaucoma treatment-showed positive effects on hearing, tinnitus, and vertigo in patients with long-standing Ménière disease (MD). We aimed to test the safety and efficacy of intratympanic treatment with latanoprost 0.0005% versus placebo in patients with active MD concerning speech discri
Objective To determine if familial diabetes burden across multiple kinship levels is associated with hospital-diagnosed COVID-19 in a population-based cohort. Methods We analyzed data from 15,516 participants in the Malmö Diet and Cancer Study (MDCS), a prospective, population-based cohort in southern Sweden. Familial burdens among first-degree relatives (parents, siblings, children) of diabetes,
Correction to: Communications Materialshttps://doi.org/10.1038/s43246-025-00842-y, published online 5 June 2025 The authors have identified an error related to the discussion of the XPS results in this Article. We incorrectly assigned some XPS features in the Ni 2p spectra to Ni3+ (Figure 7a and 7d), associated to NiOOH. However, the spectra in panel 7a are associated to Ni(OH)2 with an oxidation
Accurate calibration is essential for reliable polarimetric measurements in frequency-domain terahertz ellipsometry. In this thesis, we investigate how different sets of calibration samples influence the quality of the extracted 4×4 Mueller matrix in an in-house built terahertz Mueller Matrix Ellipsometer operating in the 170-250 GHz range. Three calibration sets composed of various combinations o
This research assesses the relationship between rainfall spatial distribution and levee failure risks by scouring at the confluence of the Chikugo River mainstream and Kusu River. Using d4PDF large climate ensembles (10,140 years of data), the study integrated a Rainfall-Runoff-Inundation (RRI) model with iRIC Nays 2DH for 2D hydro-morphodynamic analysis.The ensembles were categorized into three g
It is apparent that climate change is progressing, increasing the frequency of heavy rainfall events. In coastal areas, halocline formation caused by increased freshwater inflow can inhibit vertical mixing, reducing oxygen concentration in the bottom layer. The Ariake Sea, an inner bay in Japan with a large tidal range, has faced serious issues such as red tides and hypoxia. Previous studies
This thesis investigates how urban street design can be reimagined to increase livable public space and improve residents’ perceptions of safety in dense urban neighborhoods. Focusing on the districts of Högaborg, Eneborg, and Söder in Helsingborg, Sweden, the study examines how streetscape design interventions can address persistent negative perceptions of these areas, which residents often regar
Accumulating evidence suggests that a compromised intestinal epithelial barrier (IEB) contributes to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, the exact mechanisms remain unclear. Here we reveal that intestinal mucin 1 (MUC1) levels and glycosylation are decreased in both humans and male mice with MASLD. Enterocyte-specific Muc1 knockout aggravat
Discontinuous Galerkin (DG) methods are promising high order discretizations for unsteady compressible flows. Here, we focus on Numerical Weather Prediction (NWP). These flows are characterized by a fine resolution in z-direction and low Mach numbers, making the system stiff. Thus, implicit time integration is required and for this a fast, highly parallel, low-memory iterative solver for the resul
