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Addressing weight bias and discrimination : moving beyond raising awareness to creating change

Weight discrimination is the unjust treatment of individuals because of their weight. There have been very few interventions to address weight discrimination, due in part to the lack of consensus on key messages and strategies. The objective of the third Canadian Weight Bias Summit was to review current evidence and move towards consensus on key weight bias and obesity discrimination reduction mes

Complexity and Stigma of Pediatric Obesity

Weight stigma is rooted in a fundamental misunderstanding of the origins of obesity, wherein the interplay of behavioral, environmental, genetic, and metabolic factors is deemphasized. Instead, the widespread societal and cultural presence of weight stigma fosters misconceptions of obesity being solely a result of unhealthy personal choices. Weight stigma is pervasive in childhood and adolescence

Addressing internalized weight bias and changing damaged social identities for people living with obesity

Obesity is a stigmatized disease due to pervasive personal, professional, institutional, and cultural weight bias. Individuals with obesity experience weight bias across their lifespan and settings, which can affect their life chances and significantly impact health and social outcomes. The objectives of this study were to: (a) explore weight bias and stigma experiences of people living with obesi

Overweight and obesity in children under 5 years : Surveillance opportunities and challenges for the WHO European Region

Background: Many children who have overweight or obesity before puberty can develop obesity in early adulthood, which is associated with increased morbidity and mortality. The preschool years (ages 0-5) represents a point of opportunity for children to be active, develop healthy eating habits, and maintain healthy growth. Surveillance of childhood overweight and obesity in this age group can help

Reliable leukemia detection via transfer-enhanced Bayesian CNNs

Accurate and early detection of Acute Lymphoblastic Leukemia (ALL) is critical for timely intervention and improved patient outcomes. However, the development of reliable deep learning models for hematological image analysis is challenged by limited data availability, dataset bias, and the need for trustworthy predictions in clinical settings. In this study, we propose a Bayesian deep learning fra

Naivete and sophistication in initial and repeated play in games

Compared with more sophisticated equilibrium theory, naive, non-equilibrium behavioral rules often better describe individuals’ initial play in games. In addition, in repeated play in games, when individuals have the opportunity to learn about their opponents’ past behavior, learning models of different sophistication levels are successful in explaining how individuals modify their behavior in res

Positive effects of a perioperative training intervention in Ivor Lewis oesophageal surgery : a randomised, controlled multicentre trial

Background: The effects of peri-operative training interventions in connection with oesophageal surgery have not been thoroughly investigated. The aim of this randomised, controlled, single-blind study was to evaluate a peri-operative physical training programme in patients undergoing oesophageal cancer resection surgery due to cancer of the oesophagus or the gastro-oesophageal junction. Methods:

Joint international consensus statement for ending stigma of obesity

People with obesity commonly face a pervasive, resilient form of social stigma. They are often subject to discrimination in the workplace as well as in educational and healthcare settings. Research indicates that weight stigma can cause physical and psychological harm, and that affected individuals are less likely to receive adequate care. For these reasons, weight stigma damages health, undermine

Inequities in healthcare : a review of bias and discrimination in obesity treatment

This review is based on an exploration of the published literature over the past 20 years in the area of weight bias, stigma and discrimination and its association with obesity treatment. National and international obesity organizations have identified obesity stigma as a key barrier to effectively addressing the obesity epidemic and have called for theory driven interventions to reduce it. Both t

Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure

Background: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes like fatty acid absorption in the gut and suppresses appetite via central mechanisms. Studies in NT-deficient mice and humans implicate NT in obesity and insulin resistance, highlig

Systolic inter-arm blood pressure difference and subclinical atherosclerosis : a population-based cohort study of 29921 individuals

Inter-arm blood pressure differences (IABPDs) can be caused by atherosclerosis. We investigated 29921 men and women aged 50–64years from the nationwide population-based Swedish CArdio Pulmonary bioImage Study (SCAPIS) to evaluate if IABPD is related to risk factors for atherosclerosis and can be used as a marker of atherosclerosis as evaluated by coronary artery calcium score, arterial segment inv

Multiomic profiling of ER-positive HER2-negative breast cancer reveals markers associated with metastatic spread

Background: Metastatic disease is the main cause of breast cancer (BC)-related deaths, but prediction of metastases remains challenging especially in the large and diverse group with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative tumors. Molecular tumor features beyond currently used markers could provide important information for stratifying metastatic r

Embodied word learning in schools and sustained attention in virtual reality

This study examined whether immersive virtual reality (VR) supports second-language vocabulary learning in school-aged children compared to passive computer-based training. Seventy-three Swedish middle-school students learned novel words by assembling objects in VR and by viewing object assembly on a computer screen in a crossover design. Word recall was tested after each condition, and individual

Strategic capacity expansion planning in hydro-dominated power systems : Insights from the Nordics

Conventional capacity expansion planning (CEP) relies on a perfect-foresight planning horizon and linear investment optimisation, which fail to capture the non-linear dynamics of electricity markets. In the Nordics, hydro-related weather variability plays a critical role in maintaining the robustness of the power system. This paper addresses the intra-year perfect-foresight limitation in current C

Oxygen isotope-based evidence for stepwise climate cooling aligns with the tripartite division of the Ordovician

The Ordovician Period includes two major macroevolutionary events: the Great Ordovician Biodiversification Event (GOBE) and the Late Ordovician Mass Extinction (LOME), alongside a fundamental climate transition from a greenhouse to an icehouse state. Although both biological events occurred during relatively short-term global cooling conditions, their starkly contrasting biotic responses remain po

Correlating surface structure and electrochemical properties of polycrystalline platinum electrodes

Platinum electrodes are of key importance in electrocatalysis due to their high activity for the hydrogen evolution and oxygen reduction reactions. Industrially-relevant Pt electrodes typically exhibit significant surface heterogeneity ( i.e. , poly-/nanocrystallinity), complicating the establishment of clear relationships between structure and electrochemical properties. To unravel the influence