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Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors.We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson’s disease in marmoset monkeys. Furthermore, we tested the impact of high chronic doses of human recombinant CDNF on unlesionedmonkeys and

This article takes a selection of works of contemporary photography as starting points in a discussion about globalised movements, connections, and conflicts. The aim of the article is two-fold; first, to bring out and analyze how contemporary photography today finds new strategies with which to engage with aspects of the phenomenon of globalisation, and second, to contribute to a beginning tenden

The hippocampus is heavily affected by progressive neurodegeneration and beta-amyloid pathology in Alzheimer's disease (AD). The hippocampus is also one of the few brain regions that generate new neurons throughout adulthood. Because hippocampal neurogenesis is regulated by both endogenous and environmental factors, we determined whether it benefits from therapeutic reduction of beta-amyloid pepti

Domestication processes tend to release animals from natural selection and favour traits desired by humans, such as food-production and co-operative behaviour. A side effect of such selective breeding is the alteration of unintended traits. In this paper, we investigate how active selection for egg production in chickens has affected the visual system, in particular the optical sensitivity that re

Much research on dolphin echolocation has focused on animals that have been trained to remain stationary or to carry a device that allows the animals to move but restricts the location of the sonar beam. In such cases, a small number of hydrophones measures sonar characteristics while dolphins solve echolocation tasks. As a result, much is known about the beam axis but relatively little is known a

Ditrysia comprise close to 99 % of all butterflies and moths. The evolutionary relationships among the ditrysian superfamilies have received considerable attention in phylogenetic studies based on DNA and transcriptomic data, but the deepest divergences remain for large parts unresolved or contradictory. To obtain complementary insight into the evolutionary history of the clade, and to test previo

To investigate the effect of oral calcium (Ca2+) supplementation on insulin sensitivity measured by the euglycaemic hyperinsulinaemic clamp, intraplatelet cationic concentration of Ca2+ ([Ca2+](i)) and the transmembrane sodium-hydrogen exchanger (NHE) activity in erythrocytes in subjects with Type 2 diabetes and hypertension. In this parallel randomized controlled single-blinded trial, 31 patients

Human melanomas exhibit considerable genetic, pathologic, and microenvironmental heterogeneity. Genetically engineered mice have successfully been used to model the genomic aberrations contributing to melanoma pathogenesis, but their ability to recapitulate the phenotypic variability of human disease and the complex interactions with the immune system have not been addressed. Here, we report the u

The reaction of the ligand [1-(4-((1H-benzo[d][1,2,3]triazol-2(3H)-yl)methyl)benzyl)-1H-benzo[d][1, 2,3]triazole] (L) with CuCl2 in acetonitrile yields a dinuclear copper(II) complex [Cu2Cl4L2]center dot 2CH(3)CN (1.2CH3CN), which has been characterized by elemental analysis, powder and single crystal X-ray diffraction, thermal gravimetric analysis as well as IR, UV-Vis and EPR spectroscopy The cr

Laminar burning velocities, S-L, of nitromethane and air flames at 1 atm and initial gas temperatures, T, of 338 K, 348 K, and 358 K were determined using the heat flux method. Measurements were performed in non-stretched flames, stabilized on a perforated plate burner under adiabatic conditions. The comparison of these new experimental data and recent literature results obtained in spherical flam

The decline of one farmland bird, the migratory European starling, has been attributed to both agricultural intensification and farmland abandonment and to factors operating both during the winter and during the breeding season. We analysed population data from thirty-three Swedish nestbox colonies over more than two decades to determine if the national decline was caused by a common factor affect

A non-equilibrium quenched plasma is prepared using a gliding-arc discharge generated between diverging electrodes and extended by a gas flow. It can be operated at atmospheric pressure and applied to plasma surface treatment to improve adhesion properties of material surfaces. In this work, glass-fibre-reinforced polyester plates were treated using an atmospheric pressure gliding-arc discharge wi

The perspectives on the manufacturing footprint of global firms are widening from the economic aspects to also include the environmental and social aspects. Thus, sustainability is becoming an important issue for the location of manufacturing facilities. It is therefore timely to review the relevant aspects and dimensions in the extant literature to investigate the relationship between sustainabil

The aim of this article is to explore and discuss the role of trust and closely interrelated ethical core values such as respect, fairness, and honesty in a managerial and organisational context and to link these factors further to employee motivation, commitment and loyalty. From an identified shortage and limitation of existing frameworks of human needs and motivation, the author suggests an alt

Despite their tiny eyes and brains, nocturnal insects have remarkable visual abilities. Recent work-particularly on fast-flying moths and bees and on ball-rolling dung beetles-has shown that nocturnal insects are able to distinguish colors, to detect faint movements, to learn visual landmarks, to orient to the faint pattern of polarized light produced by the moon, and to navigate using the stars.