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MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation.

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and above all patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system cent

Structured Diagnostic and Treatment Approach Versus the Usual Primary Care Approach in Patients With Gastroesophageal Reflux Disease: A Cluster-randomized Multicenter Study.

GOALS:: To compare the clinical outcomes of gastroesophageal reflux disease (GERD) patients treated with an implemented new structured pathway (NSP) or according to existing local clinical practices [old clinical pathway (OCP)]. BACKGROUND:: GERD is a major challenge at the primary care level. STUDY:: Primary care centers (n=24) were cluster randomized to handle patients suffering from symptoms su

CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization

Nonhematopoietic bone marrow mesenchymal stem cells (BM-MSCs) are of central importance for bone marrow stroma and the hematopoietic environment. However, the exact phenotype and anatomical distribution of specified MSC populations in the marrow are unknown. We characterized the phenotype of primary human BM-MSCs and found that all assayable colony-forming units-fibroblast (CFU-Fs) were highly and

3D-GIS as a Platform for Visual Analysis : Investigating a Pompeian House

The aim of the present work is to introduce an innovative framework for employing 3D-GIS as an exploratory platform to perform visual analysis. Such a methodology is aimed at detecting patterns of visibility to simulate the past human perception of specific categories of artifacts placed inside a virtually reconstructed three-dimensional space. As a case study, the house of Caecilius Iucundus in P

Tip-Enhanced Ultrasensitive Stokes and Anti-Stokes Raman Spectroscopy in High Vacuum

We report ultrasensitive Stokes and anti-Stokes Raman spectra of 1,2-benzenedithiol monolayer on Ag film with home-made high-vacuum tip-enhanced Raman spectroscopy (HV-TERS) system. Raman peaks that were orginally very weak were observed experimentally and assigned theoretically. The local temperature was obtained based on the observed Stokes and anti-Stokes HV-TERS spectra.

Wideband SAW-Less Receiver Front-End with Harmonic Rejection Mixer in 65-nm CMOS

A wideband direct-conversion receiver front-end featuring a new harmonic rejection technique is demonstrated in 65-nm CMOS. The circuit consists of a two-stage low-noise amplifier, the first stage with capacitive feedback, a harmonic rejection mixer using 25% and 50% duty cycle local oscillator signals, and a third-order channel-select filter with configurable bandwidth. The receiver front-end is

Immunophenotypical characterization of human neutrophil differentiation

The current study reports a flow cytometry-based protocol for the prospective purification of human BM populations representing six successive stages of terminal neutrophil differentiation, including early promyelocytes and late promyelocytes, myelocytes, metamyelocytes, band cells, and PMN neutrophilic granulocytes. Validation experiments revealed a high purity of each bone marrow population and

Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype.

The Vel antigen is present on red blood cells (RBCs) from all humans except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in blood recipients. We combined SNP profiling and transcriptional network modeling to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on c

Replication of an experiment on linguistic tool support for consolidation of requirements from multiple sources

Large market-driven software companies continuously receive large numbers of requirements and change requests from multiple sources. The task of analyzing those requests against each other and against already analyzed or implemented functionality then recording similarities between them, also called the requirements consolidation task, may be challenging and time consuming. This paper presents a r

Occupational performance and factors associated with outcomes in patients participating in a musculoskeletal pain rehabilitation programme.

Objectives: To assess outcomes after a pain rehabilitation programme in terms of occupational performance and satisfaction with occupational performance, and to investigate whether socio-demographic factors and pain-related factors were associated with outcomes at follow-up. Methods: A pre- and post-test study of 555 participants with musculoskeletal pain who completed a pain rehabilitation progra

The Spirit of a Heroine: Ya Mo-Spirit Reverence, Patriotism and Thai Buddhism

The story of Ya Mo is that of a great Thai heroine honoured with a grand monument: (the Suranari memorial) in the centre of Khorat, a city in the northeast of Thailand. The monument is a sacred shrine embedding Ya Mo's guardian spirit which protects the people of the city. She is a grantor of protection, auspiciousness and good luck, and can fulfil wishes, needs and requests. Her spirit can be ben

Sample Path Asymmetries in Non-Gaussian Random Processes

We tackle an important although rarely addressed question of accounting for a variety of asymmetries frequently observed in stochastic temporal/spatial records. First, we review some measures intending to capture such asymmetries that have been introduced on various occasions in the past and then propose a family of measures that is motivated by Rice's formula for crossing level distributions of t

Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

Previous work implicated the complement system in adult neurogenesis as well as elimination of synapses in the developing and injured CNS. In the present study, we used mice lacking the third complement component (C3) to elucidate the role the complement system plays in hippocampus-dependent learning and synaptic function. We found that the constitutive absence of C3 is associated with enhanced pl

Bone loss after childhood acute lymphoblastic leukaemia: an observational study with and without GH therapy

OBJECTIVE: Bone mineral density (BMD) in survivors of acute lymphoblastic leukaemia (ALL) seems to vary with time, type of treatments and GH status. We aimed to evaluate BMD in ALL patients with growth hormone deficiency (GHD), with and without GH therapy. DESIGN: Case-control study. METHODS: 44 (21 women) GHD patients (median 25 years), treated with cranial radiotherapy (18-24 Gy) and chemotherap

Cyclodextrin-grafted cellulose: Physico-chemical characterization

Cyclodextrins (CDs) can form inclusion complexes with a wide variety of molecules making them very attractive in different areas, such as pharmaceutics, biochemistry, food chemistry and textile. In this communication we will report on the physico-chemical characterization of cellulose modified with CDs by means of infra-red spectroscopy (FTIR), cross polarization magic angle spinning solid state n

Extraction and Neoformation of Antioxidant Compounds by Pressurized Hot Water Extraction from Apple Byproducts

There is a great interest in searching for new environmentally sustainable techniques to enhance the use of agricultural byproducts. In this work, a response surface methodology was used to study the influence of the two independent variables, temperature (25-200 degrees C) and extraction time (3-17 min), in the extraction of antioxidants by pressurized hot water extraction (PHWE) from industrial

Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-/- mice

The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n =

A combined computational and experimental investigation of the [2Fe-2S] cluster in biotin synthase

Biotin synthase was the first example of what is now regarded as a distinctive enzyme class within the radical S-adenosylmethionine superfamily, the members of which use Fe/S Clusters as the sulphur source in radical sulphur insertion reactions. The crystal structure showed that this enzyme contains a [2Fe-2S] cluster with a highly unusual arginine ligand, besides three normal cysteine ligands. Ho

Small resistive wood moisture sensors: a method for moisture content determination in wood structures

The wood moisture content influences the service life of wood structures since wood is susceptible to decay by rot fungi if it is exposed to high moisture contents during long periods of time. In rain exposed structures, the moisture content close to end grain surfaces and joints can be significantly higher than the average moisture content, but moisture content determinations at such locations re