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Different approaches to primary prophylaxis in boys with severe hemophilia A
Cerebrovascular gene regulation in brain diseases
The TSG-6 and I alpha I interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link
During co-incubation of human inter-alpha-inhibitor (IalphaI) and human tumor necrosis factor-stimulated gene 6 protein (TSG-6) SDS-stable interactions are formed between the two proteins. We have analyzed the products of this reaction and characterized the mechanism of complex formation. Following the incubation seven new bands not previously identified were apparent in SDS-PAGE. Three of these b
Applying biochemical and physiological principles in the industrial freezing of vegetables: a case study on carrots
We review here the potential benefits of metabolic changes in carrots upon cold stress, a process known as cold acclimation, for the enhancement of quality upon freezing. The damaging action of a previous blanching operation is discussed and the alternative of using mild blanching treatments to minimise tissue damage is reviewed. Blanching treatments, aimed at inactivating enzymes near the surface
Downscaling of GCM forecasts to streamflow over Scandinavia
A seasonal forecasting technique to produce probabilistic and deterministic streamflow forecasts for 23 basins in Norway and northern Sweden is developed in this work. Large scale circulation and moisture fields, forecasted by the ECHAM4.5 model 4 months in advance, are used to forecast spring flows. The technique includes model output statistics (MOS) based on a non-linear Neural Network (NN) app
Effect of temperature and pressure on the proteolytic specificity of the recombinant 20S proteasome from Methanococcus jannaschii
The hydrolytic specificity of the recombinant 20S proteasom from the deep-sea thermophile Methanococcus jannaschii was evaluated toward oxidized insulin B-chain across a range of temperatures (35degrees, 55degrees. 75degrees, and 90degreesC) and hydrostatic pressures (1, 250, 500, and 1,000 atm). Of the four temperatures considered, the same maximum overall hydrolysis rate was observed at both 55d
The IgD-binding domain of the Moraxella IgD-binding protein MID (MID962-1200) activates human B cells in the presence of T cell cytokines.
Moraxella catarrhalis immunoglobulin D (IgD)-binding protein (MID) is an outer membrane protein with specific affinity for soluble and cell-bound human IgD. Here, we demonstrate that mutated M. catarrhalis strains devoid of MID show a 75% decreased activation of human B cells as compared with wild-type bacteria. In contrast to MID-expressing Moraxella, the MID-deficient Moraxella mutants did not b
Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex
We studied the effect of kindling, a model of temporal lobe epilepsy, on the frequency-dependent information transfer from the entorhinal cortex to the hippocampus in vitro. In control rats repetitive synaptic activation of layer III projection cells resulted in a frequency dependent depression of the synaptic transfer of action potentials to the hippocampus. One-to-two-days after kindling this ef
Effect of endurance flight on haematocrit in migrating birds
The effects of an endurance flight on the haematocrit, the percentage of packed red blood cells per blood volume, were examined within the framework of six possible factors explaining possible changes in the haematocrit. Two approaches were adopted: (1) the haematocrit was studied in four species of passerine birds which landed on an Italian island after having crossed the Mediterranean Sea on the
‘What does what I am doing mean to you?’ A response to the recent discussion on Tribe.
Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement.
Influence of laser pulse duration on relativistic channels
A high-power (10 TW) laser is employed to generate relativistic channels in an underdense plasma. The lengths of the channels are measured by imaging the Thomson-scattered light, and the gas densities are determined through the forward Raman scattered light. The laser-pulse parameters are varied and their impact on the channel formation is studied. It is found that increasing the laser pulse durat
Gender, risk perceptions, and smoking behavior
The underlying reasons for gender differences in smoking behavior, and thus for the recent trends, are not well understood. Using a sample of 8592 Swedish adolescents aged 15-18, this paper contributes to the literature by exploring gender differences in smoking risk perceptions and in the responses to the latter. The results show significant gender differences in the perception of smoking mortali
Health among long-term survivors of breast cancer-an analysis of 5-year survivors based on the Swedish surveys of living conditions 1979-1995 and the Swedish Cancer Registry 2000
In this paper we examine health among breast cancer 5-year survivors. We raise two questions: (1) how do the health level of this survival group compare to the health level of the general population; and (2) how have the health levels among these survivors changed over time. We found that 5-year breast cancer survivors assess their health lower than the general population, and that having being di
Effect of Customer Orientation and Innovativeness on Business Performance: a Study of Small-Sized Service Retailers
While researchers have explored the relationship between customer orientation and innovativeness with business performance in different organisations, such studies in small-sized service retailers are scarce. This study investigates potential influences of these two variables on small-sized service retailer performance. Data for this study were collected through personal interviews from 174 Swiss
MRI and non-cartilaginous structures in knee osteoarthritis
Magnetic resonance imaging (MRI) provides a sensitive tool for examining all the structures involved in the osteoarthritis (OA) process. While much of the MRI literature previously focussed on cartilage, there is increasing research on whole-organ evaluation and including features such as synovitis, bone marrow edema, and meniscal and ligamentous pathology. The aim of this session at the Outcome M
Surface forces in solutions containing semiflexible polymers
The influence of intrinsic chain stiffness on surface forces in solutions containing semiflexible polymers is investigated with density functional theory. The solvent is included explicitly, but comparisons are also made with exact results obtained with ideal chains, in the absence of solvent particles. We find that as the intrinsic stiffness increases, the polymers are at intermediate separations
Routing optimization in optical burst switching networks
Effects of hypothermia with and without buffering in hypercapnia and hypercapnic hypoxemia
Anesthetized, paralyzed and mechanically ventilated pigs were hypoventilated to extreme hypercapnia (PaCO2 approximately 20 kPa) at FiO2 0.5, and allotted to receive hypothermia (approximately 31.5 degrees C) and buffer infusion, (HB-group, n = 6) or to a hypothermic control group (H-group, n = 6). The HB-group had higher arterial pH (7.34 vs 7.09, P < 0.01) and plasma bicarbonate (58.8 vs 35.4 mm