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Erythropoietin (EPO) and its covalently modified analogs are neuroprotective in various models of brain damage and disease. We investigated the effect on brain damage and memory performance, of a continuous 3-day intravenous infusion of EPO, starting 20 min after a transient 10 minute period of global cerebral ischemia in the rat.
The synthesis of pharmaceuticals and catalysts more and more relies on enantiopure chiral building blocks. These can be produced in an environmentally benign and efficient way via bioreduction of prochiral ketones catalyzed by dehydrogenases. A productive source of these biocatalysts is the yeast Saccharomyces cerevisiae, whose genome also encodes a reductase catalyzing the sequential reduction of
New roles for dogs and humansBased on the archaeological finds during the Neolithic we interpret the relationship between humans and their dogs to have significantly changed. People gained an increased understanding of the dog's different, unique properties. The dogs were stimulated by the work and collaboration, and probably developed mentally. Maybe, dogs specialized in different tasks?The dogs
OBJECTIVE: To build mathematical models to evaluate the individual risk of endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness ≥ 4.5 mm using clinical data, sonographic endometrial thickness and power Doppler ultrasound findings. METHODS: Of 729 consecutive patients with postmenopausal bleeding, 261 with sonographic endometrial thickness ≥ 4.5 mm and
The RF performance of vertical nanowire metal-oxide-semiconductor field-effect transistors in realistic layouts has been calculated. The parasitic capacitances have been evaluated using full 3-D finite-element method calculations, combined with self-consistent Schrodinger-Poisson calculations for the intrinsic gate capacitances. It is shown that a performance comparable to planar FETs can be achie
The notion of design research entails research where design practice forms part of the knowledge production. Based on our characterization of the nature of design, we propose to conceptualize this kind of research as programmatic design research. Two ongoing PhD projects in interaction design are presented as examples of programmatic research processes, highlighting issues to do with the virtues a
Laser-induced breakdown spectroscopy (LIBS) was used in this study to measure quantitatively the sodium (Na) and potassium (K) release from burning coal particles under oxy-fuel combustion environments. A specially designed laminar premixed burner was employed to provide a postflame environment with different O-2 and CO2 concentrations, in which the effects of O-2 and CO2 on the release of Na and
Popular Abstract in Swedish Cancer uppstår via genetiska förändringar som leder till ohämmad reglering av celltillväxt. Tumörer i mjukdelar utgör en grupp av solida tumörer, med över 100 histologiska typer. Mjukdelstumörer uppstår från mesenkymal vävnad, som inkluderar fett, bindväv, muskulatur, och det perifera nervsystemet. Mjukdelstumörer är en extremt heterogen grupp, både vad gäller morfologiThe focus of this thesis was to study cytogenetic and molecular genetic aberrations in lipomas. For this purpose, chromosome banding analysis, fluorescence in situ hybridization (FISH), as well as high resolution single nucleotide polymorphism (SNP)–arrays were used to identify recurrent chromosomal aberrations in lipomas. The possible molecular targets for these aberrations were further studied t
We consider detection over intersymbol interference channels that are unknown at the receiver. For such a kind of systems, we consider an alternative approach to the design of a reduced-complexity receiver based on channel shortening without the explicit estimation of the channel impulse response. The proposed solution allows a simplification of the receiver architecture and a faster convergence f
Although advances in cardiopulmonary resuscitation have improved survival from cardiac arrest (CA), neurologic injury persists and impaired mitochondrial bioenergetics may be critical for targeted neuroresuscitation. The authors sought to determine if excellent cardiopulmonary resuscitation and postresuscitation care and good traditional survival rates result in persistently disordered cerebral mi
We present experimental measurements of the coherence of an undulator synchrotron radiation source near to the diffraction limit condition. These measurements have been done following two objectives. The first one is to verify a fundamental point of the theory of synchrotron radiation. To our knowledge, since it has been re-written by Geloni et al. [1], no experimental verification to validate the
Background: This study aimed to compare open appendectomy (OA) and laparoscopic appendectomy (LA) in children by analyzing the differences in outcomes between the two techniques. Materials and Methods: This was a single-institution retrospective study. Data were collected from the medical records of all children <15 years of age who underwent an appendectomy from 2006 through 2014. Preoperative pa
We have calculated the frequency-dependent exact-exchange (EXX) kernel of time-dependent (TD) density-functional theory employing our recently proposed computational method based on cubic splines. With this kernel we have calculated the linear density response function and obtained static polarizabilites, van der Waals coefficients, and correlation energies for all spherical spin-compensated atoms
Using the metric of channel capacity, three dual-antenna multiple-input multiple-output (MIMO) terminals with adaptive impedance matching were evaluated at LTE Band 13 in four different user scenarios using simulation. Each of the three terminals is equipped with a slot-monopole antenna and a planar inverted-F antenna (PIFA). The slot monopole is fixed at one edge of the chassis, whereas the locat
Hollow nanocapsules made of polyelectrolytes, extensively useful for biomedical and biotechnological applications, are produced with a simple Layer-by-Layer approach using liposomes as template. The biocompatible polymers, alginate and chitosan, are alternatively adsorbed onto liposomes allowing the achievement of small size hollow nanocapsules with an average diameter of similar to 280 nm. Hollow
The effect of modulating the structure of thin pentacene (C22H14) films by a nanopatterned inert substrate, known as hexagonal boron nitride nanomesh, is reported. Films of different thickness are grown and characterized by x-ray absorption, core-level photoemission, low-energy electron microscopy, microbeam low-energy electron diffraction, and scanning tunneling microscopy. Initially the pentacen
