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The existing information supports the use of these materials as described in this safety assessment. The 167 materials identified in this assessment were evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Target data, read-across analogs and TTC show that these materi
The existing information supports the use of this material as described in this safety assessment.Ethyl 4-pentenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that ethyl 4-pente
Pauline scholarship has gone through fundamental changes during the last decades. Old assumptions and premises have been questioned, debated and reformulated through the New Perspective on Paul. A more recent scholarly trend is known as the Paul Within Judaism Perspective (also labelled the Radical New Perspective on Paul). This article focuses on 2 Corinthians 3 in relation to this development an
Background: There is increasing interest in nonmorbid treatments for low- and intermediate-risk prostate cancer with fewer side effects than surgery or radiotherapy. Objective: To investigate the tolerability, safety, and antitumor effects of the intraprostatic NanoZolid depot formulation Liproca Depot (LIDDS AB, Uppsala, Sweden) with antiandrogen 2-hydroxyflutamide (2-HOF) in men with low- or int
Low-grade gliomas (LGGs) are the most common childhood brain tumor in the general population and in individuals with the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Surgical biopsy is rarely performed prior to treatment in the setting of NF1, resulting in a paucity of tumor genomic information. To define the molecular landscape of NF1-associated LGGs (NF1-LGG), we integrated cli
Global climate change is driving species' distributions towards the poles and mountain tops during both non-breeding and breeding seasons, leading to changes in the composition of natural communities. However, the degree of season differences in climate-driven community shifts has not been thoroughly investigated at large spatial scales. We compared the rates of change in the community composition
Long-term electrocardiogram (ECG) monitoring is a standard clinical routine in cryptogenic stroke survivors to assess the presence of atrial fibrillation (AF). However, manual evaluation of such recordings is time consuming, in particular when brief episodes are of interest. The electrocardiomatrix (ECM) technique allows compact, two-dimensional representation of the ECG and facilitates its review
Abstract: The physicomechanical properties and structure of superhard cBN–Ti4WC5–Al materials were studied. The materials were sintered under a pressure of 7.7 GPa within a broad range of temperatures (1600–2450°C). The formation of a dense material with high physicomechanical properties was found at a sintetring temperature of 1800°C. A further increase in the sintering temperature had a negligib
Hydrogen peroxide treatment is a cost-effective and simple method to improve the bioactivity of titanium implants. In this study, the effects of chloride ion concentration and temperature of hydrogen peroxide on the surface treatment of titanium were investigated using X-ray diffractometry (XRD), Field Emission-Scanning Electron Microscopy (FESEM), and tests in order to determine wettability and a
Several studies have shown that the autonomic nervous system (ANS) can induce changes during atrial fibrillation (AF). There is currently a lack of methods for quantifying ANS induced variations during AF. The purpose of this study is to quantify respiratory induced modulation in the f-wave frequency trend. Following qrst-cancellation, the local f-wave frequency is estimated by fitting a harmonic
Studies investigating risk factors associated with atrial fibrillation (AF) have mostly focused on AF presence and burden, disregarding the temporal distribution of AF episodes although such information can be relevant. In the present study, the alternating, bivariate Hawkes model was used to characterize paroxysmal AF episode patterns. Two parameters: the intensity ratio µ, describing the dominat
The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded fro
The present study addresses the problem of respiratory rate estimation from ECG-derived respiration (EDR) signals during paroxysmal atrial fibrillation (AF). Novel signal-to-noise ratios between various components of the ECG including the influence of respiration, measured by QRS ensemble variance, the amplitude of fibrillatory waves (f-waves), and the QRS amplitude are introduced to characterize
