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IMPORTANCE Heart failure (HF) aggregates in families, but the heritability of HF has not been determined. Discerning the genetic and environmental contributions to HF risk is important to further helping to identify individuals at risk. Adoption studies may establish the genetic contribution to HF. OBJECTIVE This nationwide adoption study aimed to determine the heritability of HF. DESIGN, SETTING,
Background: Nerve growth factor (NGF) and brain-derived neural factor (BDNF) are important for brain function and detectable in the blood. This study explored the longitudinal associations of physical activity and body fat with serum NGF and BDNF in children. Methods: Two waves of measurements were performed 2 years apart in 8- to 11-year-old children, including physical activity using the ActiGra
In this issue of Blood, Dai et al demonstrate a dynamic interchange of cell surface-bound platelet factor 4 (PF4) among hematopoietic and vascular cells that may limit the thrombocytopenia and promote prothrombotic processes in heparin-induced thrombocytopenia (HIT).
Additive Manufacturing (AM) is a technology that, while removing many of the constraints of traditional manufacturing, imposes some new constraints of its own. Because of this, engineers and designers need to be taught a new set of skills in design for additive manufacturing (DfAM) in order to become competent in designing parts that maximize the benefits offered by AM. Around the world, universit
We apply the Atkinson (1970) inequality index to time series of asset returns to offer a novel measure of financial risk consistent with expected-utility theory. This measure is converted to a certainty-equivalent return serving as a performance measure. We extend the Atkinson index to HARA utility and derive closed-form solutions to our measures for a number of preference-return combinations. Fur
The usual pigmentation pattern in mammalian skin consists of fixed melanocytes in the basal layer of the epidermis, supplying keratinocytes with melanosomes. We observed that the glabrous skin (rhinaria and footpads) of dogs deviates from this pattern. In dogs, melanocytes are found in both the dermis and epidermis. The epidermal melanocytes are situated in the intercellular spaces of the basal an
Context. Spectroscopy across spatially resolved stellar surfaces reveals spectral line profiles free from rotational broadening, whose gradual changes from disk center toward the stellar limb reflect an atmospheric fine structure that is possible to model by 3D hydrodynamics. Aims. Previous studies of photospheric spectral lines across stellar disks exist for the Sun and HD 209458 (G0 V) and are n
BACKGROUND: The FORS histo-blood group system was described in 2013 and much remains to be investigated regarding its genetic and immunohematologic characteristics, as well as its clinical importance. While presence of the c.887G>A-mutated GBGT1 gene, which results in FORS1 glycosphingolipid expression on human red blood cells (RBCs), is rare in the populations tested so far, naturally occurring a
Aims: We aimed to evaluate the impact of delay from diagnostic pre-hospital electrocardiogram (ECG) to wiring of the infarct-related vessel (ECG-to-wire) >120 minutes on cardiovascular magnetic resonance (CMR) markers of reperfusion success and clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI). Methods and results: We included 1,492 patients in the analyses of cl
Many Frankia strains are pigmented and presumed to produce melanin. However, melanin biosynthesis has yet to be rigorously characterized in Frankia. This study was initiated to determine whether or not Frankia strain CeI5 produced melanin and to identify the biochemical pathway of pigment production. Frankia strain CeI5 first produced a dark pigment in mycelial and other tissue and then in the liq
The fate of pollutants in rivers is mainly affected by the longitudinal dispersion coefficient (Kx). Thus, improved Kx estimation could greatly enhance the water quality management of rivers. In this regard, evolutionary polynomial regression (EPR) was used to accurately predict Kx in rivers as a function of flow depth, channel width, and average and shear velocities. The predicted Kx by EPR model
We perform a land-surface model intercomparison to investigate how the simulation of permafrost area on the Tibetan Plateau (TP) varies among six modern stand-alone land-surface models (CLM4.5, CoLM, ISBA, JULES, LPJ-GUESS, UVic). We also examine the variability in simulated permafrost area and distribution introduced by five different methods of diagnosing permafrost (from modeled monthly ground
The sharing economy has many faces, and it has taken our societies by storm. For many people, it has quickly become a norm to book accommodation via AirBnB, or to think sharing instead of owning when it comes to products of their everyday lives. The tourism industry has seen many adaptions towards a sharing economy, one of them being a new way of conducting guided tours. Based on an innovation in The sharing economy has many faces, and it has taken our societies by storm. For many people, it has quickly become a norm to book accommodation via AirBnB, or to think sharing instead of owning when it comes to products of their everyday lives. The tourism industry has seen many adaptions towards a sharing economy, one of them being a new way of conducting guided tours. Based on an innovation in
Om artificiell intelligens som regleringsfråga och tillsynsutmaning i en replik på Daniel Akenines (teknikchef Microsoft Sverige) debattartikel i SvD.
1. IntroductionThe end of the 20th century was marked by the start of the third and so far final wave of biotechnology, the so-called white biotechnology, aiming to substitute chemical processes based on C2/C3 chemistry of oil and gas by biotechnological processes. The standard conversion process in biotechnology is fermentation, which is used to produce a wide range of bulk products such as antib
Dextrose syrups are produced from starch by liquefaction combined with saccharification. In the conventional production process, rotary vacuum filters (RVFs) with a diatomaceous earth (kieselguhr) coating as filter aid are often used for removal of the so-called mud phase after the liquefaction and saccharification step. This mud phase consists of insoluble impurities and suspended solids such as
Over the last two decades the market for membrane technology in the food industry increased to a market volume of approx. € 50 million and is now the second largest industrial market for membranes after municipal water treatment in Germany. The key membrane technologies in the food industry are the pressure driven membrane processes; microfiltration, ultrafiltration, nanofiltration and reverse osm
Membrane processes, antibiotics, enzymes, biofuels and biochemicalsThe end of the 20th century was marked by the start of the third and so far final wave of biotechnology, the so-called white biotechnology, aiming to substitute chemical processes based on C2/C3 chemistry of oil and gas by biotechnological processes. The standard conversion process in biotechnology is fermentation, which is used to
The starch and yeast industries are two key sectors of the European food industry, with annual turnovers of approx. € 4 billion and € 500 million, respectively, in Europe alone. The production processes in the starch and yeast industries are still dominated by conventional separation processes such as evaporators, separators and rotary vacuum filters (RVFs), and membrane processes are only rarely
