High-throughput screening (HTS) three-dimensional (3D) tumor models are a promising approach for cancer drug discovery, as they more accurately replicate in vivo cell behavior than two-dimensional (2D) models. However, assessing and comparing current 3D models for drug efficacy remains essential, given the significant influence of cellular conditions on treatment response. To develop in vivo mimic

In this study, the thermal behavior in a Type IV hydrogen storage tank during fast charging was investigated by establishing a 2-dimensional axisymmetric model. The thermal properties of the real high-pressure hydrogen were considered and obtained from REFPROP software. The computing mesh with 15312 girds, the time step of 0.001 s, and the Realizable k-ε turbulence model were chosen to simulate hi

Recognising the increasing complexities posed by climate challenges to urban environments, it is crucial to develop holistic capabilities for urban areas to effectively respond to climate-related risks, forming the backbone of sustainable urban planning strategies and demanding a comprehensive understanding of urban climate justice. It requires a thorough examination of how climate change exacerba

This study investigates the interaction of KEIF, the intrinsically disordered N-terminal region of the magnesium transporter MgtA, with lipid bilayers mimicking cell membranes. Combining experimental techniques such as neutron reflectometry (NR), quartz-crystal microbalance with dissipation monitoring (QCM-D), synchrotron radiation circular dichroism (SRCD), and oriented circular dichroism (OCD),

What does it mean for a business or industry to be and do good? And who can count themselves within the good economy? This article investigates the justification of goodness in mineral exploration and mining and uses the entwinement between value creation and destruction characteristic of mining to trouble notions of goodness in impactful industries. Based on analyses of indepth interviews, ethnog

Human rights defenders, social leaders, and environmental and indigenous activists fight for political, cultural, social, economic, and environmental rights and often face intimidation and violence as a consequence. In this article, we analyze how the implementation of the peace agreement signed in 2016 between the government of Colombia and the FARC-EP guerrilla group affects environment and huma

Geometry projection-based topology optimization has attracted a great deal of attention because it enables the design of structures consisting of a combination of geometric primitives and simplifies the integration with computer-aided design (CAD) systems. While the approach has undergone substantial development under the assumption of linear theory, it remains to be developed for non-linear hyper

Purpose: Oligometastatic gastroesophageal cancer is a clinical entity with no standard treatment recommendation. Treatment with curative intent has recently emerged as an option for selected patients in contrast to the traditional palliative treatment strategy. This prospective study aimed to assess the safety and efficacy of combined systemic and local treatment with curative intent for patients

A new metaheuristic optimizer combined with artificial neural networks is proposed for streamflow prediction. Hence, the study aimed to forecast monthly streamflow of the main rivers in Urmia, Iran, by considering data shortage and using artificial neural network (ANN) models. By combining three variables: temperature, precipitation, and streamflow, we formulated five patterns, where 70% of the da

The utilization of industrial side streams for generating value has always been of interest, but in today's society, with a high focus on the circular economy, it is becoming increasingly important. Lime mud (whose major component is calcium carbonate, CaCO3) is a low-value by-product of the pulp and paper industry that is generated in considerable amounts during the causticizing process. Designin

Due to the large-scale production of lignin, continuous flow reactors are preferred for its further valorization through depolymerization. However, there is limited literature on their use in lignin depolymerization, especially concerning feedstock pretreatments and catalyst deactivation. Therefore, in this study, the impact of a batch solvolysis pretreatment on the mild reductive catalytic depoly

Mild reductive catalytic depolymerization (MRCD) of lignin offers a sustainable route to produce functionalized aromatic compounds. However, the economic viability is hindered by the need for expensive palladium (Pd) catalysts and the limited exploration of continuous flow reactors (CFRs), which are essential to achieve an adequate production scale. This study examines the impact of partial replac

Lignosulfonate, a macromolecular byproduct derived from the paper and pulp industry, is a promising feedstock for bioconversion processes due to its rich carbon content and widespread availability. We here present an approach for the production of muconic acid through the optimization of the oxidative depolymerization of lignosulfonate and its further conversion using a recombinant Pseudomona

Hen egg-white lysozyme (HEWL) is a widely used model protein in crystallographic studies and its enzymatic mechanism has been extensively investigated for decades. Despite this, the interaction between the reaction intermediate and the catalytic Asp52, as well as the orientation of Asn44 and Asn46 side chains, remain ambiguous. Here, we report the crystal structures of perdeuterated HEWL and D2O b

This review examines the complex interaction between heavy metals and soil microorganisms, focusing on five common heavy metals (HM) (chromium -Cr-, copper -Cu-, nickel -Ni-, lead -Pb-, and zinc -Zn-) in polluted areas worldwide. The systematic review was performed following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The literature selection procedure i