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Engineered nanomaterials in in vivo and in vitro models

Nanotechnology and engineered nanomaterials (ENM) empower existing technologies. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range. The occupational safety and hazard organizations draw attention to ENM, as their physical and chemical characteristics differ from the ones of bulk materials. Additionally, the NW high aspect ratio geometry is of gr

A sol-gel integrated dual-readout microarray platform for quantification and identification of prostate-specific antigen

Here, we report a sol-gel integrated affinity microarray for on-chip matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), which enables capture and identification of prostate-specific antigen (PSA) in samples. Protein microarray technologies, which involve miniaturizing spots of capture agents (such as antibody and aptamers) on a solid surface, enable multia

Community-acquired pneumonia and Gram-negative bacilli in Cambodia-incidence, risk factors and clinical characteristics

Background: In Western settings, community-acquired pneumonia (CAP) due to Gram-negative bacilli (GNB) is relatively rare. Previous studies from Asia, however, indicate a higher prevalence of GNB in CAP, but data, particularly from Southeast Asia, are limited. Methods: This is a prospective observational study of 1451 patients ≥15 y of age with CAP from two hospitals in Cambodia between 2007 and 2

Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease

Objective To compare PET imaging of tau pathology with CSF measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for Alzheimer disease (AD). Methods We compared t-tau and p-tau and 18 F-AV-1451 in 30 controls, 14 patients with prodromal AD, and 39 patients with Alzheimer dementia, recruited from the Swedish BioFINDER study. All patients with AD (prodrom

Multinational mining companies, employment and knowledge transfer : Chile and Norway from ca. 1870 to 1940

This article compares employment at multinational mining companies in Chile and Norway from ca. 1870 to 1940. I find that multinationals in Chile recruited foreigners to managing and middle-management positions, while Norwegian workers were heavily involved in management of multinationals in Norway. The exclusion of Chileans encouraged enclave tendencies and prevented knowledge transfer, while str

Volumetric breast density measurement for personalized screening : Accuracy, reproducibility, and agreement with visual assessment

Assessment of breast density at the point of mammographic examination could lead to optimized breast cancer screening pathways. The onsite breast density information may offer guidance when to recommend supplemental imaging for women in a screening program. In this work, performance evaluation of a new software (Insight BD, Siemens Healthcare GmbH) for fast onsite quantification of volumetric brea

Design for me?

In this paper, as a generative contrast to the notion of design “for all”, we present and discuss the potential benefits of a design “for me” approach, where the design process from the starts from, and initially is targeted at, just one person. Given many things developed for a user group or a constructed average user, in this text we describe starting from design for a single user as an alternat

Municipally Owned Enterprises as Danger Zones for Corruption? How Politicians Having Feet in Two Camps May Undermine Conditions for Accountability

The market-inspired reforms of New Public Management have been particularly pronounced in Swedish local government. Notably, municipally owned enterprises (MOEs) have rapidly grown in numbers. Principal-agent theory gives rise to the hypothesis that the massive introduction of MOEs has impacted negatively on the conditions for accountability in Swedish local government. To study this, social netwo

Limits to EU Powers : a case study on individual criminal sanctions for the enforcement of EU law

The question posed by this thesis is how limits can be constructed to the exercise of EU powers. While there are limits to the exercise of EU competences in the Treaties and in the Court of Justice’s jurisprudence, it is argued that those limits suffer from conceptual and practical problems. In particular, the Court does not have appropriate criteria to examine whether the limits of the Treaties h

Long-term improvements after mindfulness-based group therapy of depression, anxiety and stress and adjustment disorders : A randomized controlled trial

Background: Although mindfulness-based group therapies (MGTs) for depressive, anxiety or stress and adjustment disorders are promising, there is a substantial lack of knowledge regarding the long-term improvements after such therapies in these common psychiatric disorders. Methods: Two hundred and fifteen patients were randomized in a randomized clinical trial (RCT) (ClinicalTrials.gov ID: NCT0147

Dietitian visits were a safe and cost-effective form of follow-up care for children with celiac disease

Aim: This study compared follow-up protocols for paediatric celiac disease (CD) led by either paediatricians or dietitians at Swedish university hospitals. Methods: We followed 363 CD patients under 18 years at the university hospitals in Malmö (n = 140) and Lund (n = 79) between 2011 and 2013 and after they merged to become Skåne (n = 144) between 2014 and 2016. Both Lund and Malmö provided regul

Disclosure of payments by pharmaceutical companies to healthcare professionals in the United Kingdom: analysis of the Association of the British Pharmaceutical Industry’s Disclosure UK database, 2015 and 2016 cohorts

Objectives: To analyse the section of Disclosure UK that pertains to healthcare professionals (HCPs) in order to provide insight into the database’s structure and content and suggest ways to improve its transparency.Design and participants; Cohort study of drug companies and HCPs in the 2015 and 2016 versions of Disclosure UK.Results: Companies report transfers of value (ToVs) to named HCPs or, wh

Depoliticisation, water, and environmental peacebuilding

This chapter addresses the politics of water and the interplay between depoliticisation, technocracy and peacebuilding. Water scarcity is often framed with a dual emphasis on the conflictual and cooperative dimensions. Hence, water is an important and prioritised area of environmental peacebuilding (Conca and Dabelko 2002). At the same time, there is something puzzling about the interaction betwee

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Royal tombs and monuments, such as the imperial tombs of India and the Escorial of Spain, are among the best-known monuments of the early modern period. This article compares the Escorial, which served as the dynastic vault for the Spanish Habsburgs but particularly glorified Emperor Charles V, and the tomb built for the Mughal emperor Humayun. Both were built by their sons, Philip II (r. 1556-159

Regulatory scientists' work has important ramifications for public health and should be open to public scrutiny

The Swedish Medical Products Agency (MPA) objects to the fact that we occasionally refer to one of its senior ex-employees by name. However, names of individual MPA assessors, FDA reviewers, and EMA rapporteurs and co-rapporteurs are reported in regulatory documents and are a matter of public record. In our paper we in no way suggest that regulatory decisions were left to individual reviewers or a

Amyloid network topology characterizes the progression of Alzheimer's disease during the predementia stages

There is increasing evidence showing that the accumulation of the amyloid-β (Aβ) peptide into extracellular plaques is a central event in Alzheimer's disease (AD). These abnormalities can be detected as lowered levels of Aβ42 in the cerebrospinal fluid (CSF) and are followed by increased amyloid burden on positron emission tomography (PET) several years before the onset of dementia. The aim of thi

Cu5In3-Cu3In2 Revisited

The η-phase field of the Cu–In system is unusually rich and shows wealth of phases that are all related to the B8 (NiAs/Ni2In) type. Previous electron diffraction work has revealed extensive super structure ordering; in this study, we report single crystal diffraction experiments on high-quality samples of two of the phases in the system, ht1-Cu5In3 and ht2-Cu5In3. Both these phases constitute sup