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More than 98% of global plastics are currently derived from fossil resources. Among these, aromatic polyesters such as polyethylene terephthalate (PET) pose severe environmental challenges, driving high greenhouse gas emissions and persistent global waste accumulation. Transitioning toward a sustainable plastics economy requires decoupling polymer production from traditional petroleum feedstocks i
The Posit number system features tapered precision, providing higher accuracy for values near unity while maintaining a wide dynamic range, making the format an attractive alternative to IEEE 754 for machine-learning workloads. This work presents CPAU, a unified and configurable Posit arithmetic architecture that integrates a quire-based MAC unit and a general-purpose execution unit supporting add
AimsCardio-oncology has emerged as a rapidly growing discipline of cardiology. Despite its clinical relevance, structured education remains limited across medical curricula. The Cardio-Oncologists Of tomorrow Leaders (COOL) group of the European Society of Cardiology (ESC) Council of Cardio-Oncology conducted an international survey to assess the current state of cardio-oncology training opportuni
Introduction: Physical activity (PA) intensity can be expressed in absolute terms (metabolic equivalents, METs) or relative to individual capacity (percentage of maximal oxygen consumption, VO₂max), and these two approaches yield markedly different interpretations of health-related PA. This study examined how time spent at absolute and relative PA intensities relates to cardiorespiratory fitness (
The adeno-associated virus (AAV) alpha-synuclein (α-syn) overexpression model of Parkinson's disease (PD) shares many etiopathological features of the human disease, including the formation of aggregated α-syn, neuroinflammation, and nigral neurodegeneration. However, despite the high face validity of this model, it is notoriously variable, yielding inconsistent results with seemingly similar meth
Phenolic acid decarboxylases (PADs) convert bio-based hydroxycinnamic acids into valuable hydroxystyrene monomers under mild reaction conditions. These compounds are in high demand in polymer production, cosmetics, and flavoring. Especially 4-vinyl syringol, the decarboxylation product from sinapic acid, generates polymers with similar thermal stability and higher glass transition temperatures tha
Our perception of input from one sensory modality is malleable by inputs from other sensory modalities, also when they are non-coincident in time. This function has been critical for survival throughout evolution. How it arises may reveal fundamental principles of brain operation and inform the design of more intuitive human-machine interfaces and Virtual Reality (VR). Here we outline how the brai
Colloidal self-assembly is a powerful strategy to obtain materials with desired softness, porosity and biocompatibility. When soft building blocks are used, these properties can change dramatically, compared to materials produced using hard particles. However, the fate of individual colloids inside these assemblies is not fully understood. Here, asymmetric mixtures of soft microgels with opposite
Narwhal tusks are among the most intriguing structures in biology due to their immense size and unique left-handed helix. Whether this unique macroscopic homochirality originates in the structural arrangement of tusk building blocks has remained elusive. Therefore, we combined multiple structural techniques to reveal the hierarchical structure of the narwhal tusk from its building blocks (minerali
Highlights: Two visual effects attributed to visibility: loss of contrast and loss of detail. Smoke and fog density affected headway during driving in virtual reality. Some participants followed the lead vehicle while others lagged behind. Limitations of virtual reality could have an impact on driving behavior. Abstract: Understanding human behavior during wildfire evacuations helps to improve the
We address how surface topology controls the multiscale flow alignment of cellulose nanocrystal (CNC) suspensions using a single in-situ experiment that combines rheology, polarized light imaging (PLI), and small-angle X-ray scattering (SAXS). Across a series of azetidinium-based dialkyl linker topologies, we resolve the propagation of alignment from the mesoscale (PLI) to the nanoscale (SAXS). Wh
Background Pain, fatigue, and impaired health-related quality of life are common manifestations of rheumatoid arthritis. The aim of this study was to compare the effects of active conventional treatment with three different biological disease-modifying antirheumatic drugs (DMARDs) on patient-reported outcomes after 48 weeks, in patients with early rheumatoid arthritis using data from the NORD-STAR
BACKGROUND Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). However, this treatment carries a significant risk of acute kidney injury (AKI), especially with cisplatin-based regimens. Sodium thiosulfate (ST) is established as a nephroprotective treatment in cisplatin-based HIPEC, but i
Aim: The randomized COLOPEC trial demonstrated no benefit of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing peritoneal metastases in locally advanced colon cancer. Because all patients underwent a diagnostic laparoscopy at 18 months, the study lacked a true control arm, leaving the effect of early detection and treatment compared with standard care uncertain. This study a
The same dataset can be analysed in different justifiable ways to answer the same research question, potentially challenging the robustness of empirical science1, 2–3. In this crowd initiative, we investigated the degree to which research findings in the social and behavioural sciences are contingent on analysts’ choices. We examined a stratified random sample of 100 studies published between 2009
AbstractBackgroundMinimally invasive surgery (MIS) improves short-term outcomes in elective colectomy, however, the choice of surgical approach in hemodynamically stable patients with obstructing right-sided colon cancer remains unclear in emergency settings. MIS could be considered and the present study aims to evaluate short-term outcomes of MIS in bowel obstructed patients compared with open su
Macrocyclic peptides are a growing class of pharmaceuticals, due to their high target specificity and improved properties, solubility, permeability and metabolic stability compared to linear peptides. Disulfide bonds are commonly used as linkers; however, disulfide bonds are proven to be metabolically instable. This study explores alternative linkages to replace the disulfide bond for two existing
