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The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.O.T.) consensus meetings, where a core set of PROMs to
PURPOSE: The focus of measuring success in obesity treatment is shifting from weight loss to patients' health and quality of life. The objective of this study was to select a core set of patient-reported outcomes and patient-reported outcome measures to be used in clinical obesity care.MATERIALS AND METHODS: The Standardizing Quality of Life in Obesity Treatment III, face-to-face hybrid consensus
Intro: Population-based studies predominantly focused on carcinoma of the parotid gland (CPG) are rare. The study aims were to analyze the incidence of CPG and to assess treatment outcomes in relation to histopathology, preoperative diagnosis and adjuvant radiotherapy. Methods: A retrospective analysis was conducted on data from the Swedish Head and Neck Cancer Register (SweHNCR), including 1,018
PURPOSE: To develop Mexico's first methodologically rigorous clinical practice guideline for the management of adult overweight and obesity. The target audiences are interdisciplinary healthcare professionals across healthcare systems who are the first point of contact for patients with obesity in Mexico, patients, and health system decision makers.RECENT FINDINGS: A review of recent international
BACKGROUND: An international panel of obesity medicine experts from multiple professional organizations examined patterns of obesity care and current obesity treatment guidelines to identify areas requiring updating in response to emerging science and clinical evidence.AIMS: The panel focused on multiple medical health and societal issues influencing effective treatment of obesity and identified s
Shared e-scooters (SEs) are increasingly integrated into urban mobility systems, yet their role in commuting and contribution to sustainable transport remain insufficiently understood. This study examines SE commuting patterns in Malmo, Sweden, focusing on their use as both a first-/last-mile connection to public transport and a primary commuting mode. Using pre-pandemic trip data from a major SE
Weight bias is a social justice issue that manifests in social and health inequities, affecting the lives of millions of individuals globally. Although weight bias research has increased over the last two decades, it remains pervasive, and more work is needed to establish effective strategies to reduce it. The 2024 International Weight Bias Summit aimed to collaboratively identify future research
Background Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis. Still, little is known about the individual variation over time of the prothrombin concentration in plasma in the general population. Objectives This study aimed to establ
Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t
The use of remote sensing and reanalysis weather data has not been adequately acknowledged for large-scale built environment applications, primarily regarding engineering analyses that traditionally rely on computationally expensive numerical models. This study employs a parsimonious data-driven approach concerning service life assessment of rain-exposed wooden components, enabling mapping and ass
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic stroma, which plays a crucial role in tumor biology and treatment resistance. While the stromal compartment is a defining histopathological feature of PDAC, its prognostic significance remains incompletely understood. This study aimed to quantify the stromal content in PDAC using digital pathology and
The bladder trigone is a distinct anatomical and functional subregion of the urinary bladder, defined by its triangular configuration between the ureteral orifices and the internal urethral orifice. Although traditionally less studied compared to the bladder dome and detrusor body, recent morphological, molecular, and transcriptomic analyses reveal that the trigone is highly specialized. Understan
Understanding greenhouse gas fluxes in semi-arid ecosystems is critical for improving our understanding of biogeochemical cycles, particularly in underrepresented regions like the African Sahel. In these landscapes, greenhouse gas exchange arises from ground, trees, and water ponds, and is further shaped by environmental conditions and grazing. The carbon dioxide, methane, and nitrous oxide fluxes
Leigh syndrome is a fatal pediatric neurodegenerative disease caused by mitochondrial dysfunction, which can be modeled in the Ndufs4 KO mouse with mitochondrial respiratory chain complex I (CI) deficiency. This study explores NV354, a prodrug of succinate with enhanced oral bioavailability and brain uptake, as a potential therapy to counteract this devastating condition. NV354 modulated whole-bod
In recent years, international non-governmental organisations (INGOs) in India have operated under intensifying regulatory constraints that have profoundly reshaped the civic terrain. Legal instruments such as the Foreign Contribution Regulation Act (FCRA) do not simply restrict INGOs’ activities; they recalibrate the conditions under which civil society can exist, act, and speak. This article
Imagination shapes politics. It determines not only the futures we envision but the very forms of collective life we deem possible. Yet under neoliberal governance, imagination itself is under erasure; not merely the imagining of radical futures, but the conceptual boundaries of what can be imagined. Civil society, long imagined as a space of participation and solidarity beyond state and market, i
This study presents a comprehensive investigation of the structural, microstructural, electrical, magnetic, and magnetoelectric properties of low-level substitution of Co3 + for Fe3+ ions in the perovskite B-site of BiFeO3 (BiFe1−xCoxO3, x = 0.01, 0.015 and 0.02). X-ray diffraction combined with Rietveld refinement confirms the retention of the rhombohedral R3c structure across all compositions, w
Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her
This study provides an in-depth analysis of the impact of a multimodal journey-planning app on users of informal public transport systems in Cochabamba, Bolivia. We analyze survey data (N=648) collected through the Trufi Association NGO's digital travel app on changes in mobility behavior, satisfaction, and everyday life improvements. Participants report more frequent use of informal transport (49
