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Objective: The objective of this study was to compare health-related quality of life (HRQoL) and work productivity in axial SpA (axSpA) and non-axSpA patients with chronic back pain of <2 years. Methods: Baseline and 2-year data for patients included in the SPondyloArthritis Caught Early cohort were analysed. HRQoL was assessed by the physical (PCS) and mental component summary (MCS) scores of the
We demonstrate the existence of a first-order prewetting transition of a supracritical model polymer solution adjacent to an attractive surface. The model fluid we use mimics (qualitatively) an aqueous polyethylene oxide solution and, like the actual solution, displays a closed loop 2-phase region with an upper and lower critical solution temperature. The model fluid is shown to undergo a prewetti
Iron is indispensable for the vast majority of organisms, and iron homeostasis plays a pivotal role in both the physiology and pathogenesis of fungal pathogens. However, the underlying mechanisms by which iron homeostasis modulates fungal pathogenesis remain to be fully elucidated. We therefore focused on investigating the functions of mitochondrial iron transporter ClMrs3/4 in virulence. We condu
Digital control systems introduce unavoidable computational latencies. For some controllers this time delay inhibits practical use, even though they in theory could provide more efficient control. For example, solving an optimization problem each sampling period when using model predictive control. By sampling faster than the computation time and executing independent controllers on distributed ha
I Sverige förekommer flera olika journalsystem inom sjukvården, vilket innebär att journalanteckningar ser olika ut beroende på vilket journalsystem som används. Strukturen hos journalanteckningarna skiljer sig till viss del åt. I denna artikel undersöks hur strukturen ser ut i olika journalsystem och hur journalanteckningarnas delar benämns. Sammantaget råder det på ett övergripande plan ingen en
Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highli
Future exposure to coastal flooding in China is driven more by growing populations and economic activity rather than by rising seas and intensifying storm surges. Policymakers must anticipate these multiple risk drivers to better inform spatial planning and development strategies and to ensure effective, sustainable coastal adaptation.
Balance functions have been regarded in the past as a method of investigating the late-stage hadronization found in the presence of a strongly-coupled medium. They are also used to constrain mechanisms of particle production in large and small collision systems. Charge balance functions for inclusive and identified particle pairs are reported as a function of charged particle multiplicity in proto
The efficiency and stability of wide bandgap (WBG) perovskite solar cells (PSCs) are constrained by photo-induced halide segregation and severe non-radiative recombination, which significantly impedes the advancement of high-efficiency and stable perovskite/silicon tandem solar cells (PSTSCs). In this work, a potassium 4-sulfonic-1,8-naphthalic anhydride salt (4S-NAPS), featuring dual-anchoring si
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has a relapsing-remitting course and, even with the availability of effective maintenance therapies such as rituximab, relapse rates remain high. Relapse is associated with the accrual of organ damage stemming from both the underlying disease and from the effects of AAV treatments; thus, early detection and proactive prevention
In a previous paper, a comprehensive clinicopathologic approach to mild and moderate bleeding disorders (MBD) was proposed by an international working group (IWG) as a part of a project promoted by the European Hematology Association (EHA) on the development of guidelines on the various MBDs. A single pre-diagnosis grade 4 bleeding event according to the ISTH-BAT scale or a comparable event after
The molecular pathways influencing the build-up of β-amyloid and tau pathology in Alzheimer's disease are unclear. To investigate how the involvement of different cell types influences β-amyloid and tau, we utilized single-cell RNA-seq data to derive cell-weighted polygenic risk scores. We included participants from the BioFINDER-1 study, including cognitively unimpaired (N = 734) individuals and
In 2003, the Swedish Municipal Workers’ Union (Kommunal) called a nationwide strike, demanding a pay rise for all members in the public sector. Drawing on oral history interviews with workplace representatives and local union officials, the article examines how the struggle enabled changes in subjectivity, generating utopian visions for increased visibility and agency for municipal workers. This p
In this perspective, we ask the question whether the apparently lower solubility of specific proteins in amyloid disease is a cause or consequence of the protein deposition seen in such diseases. We focus on Alzheimer's disease and start by reviewing the experimental evidence of disease-associated reduction in the measured concentration of amyloid β peptide, Aβ42, in cerebrospinal fluid. We propos
Ancient environmental DNA is increasingly vital for reconstructing past ecosystems, particularly when paleontological and archaeological tissue remains are absent. Detecting ancient plant and animal DNA in environmental samples relies on using extensive eukaryotic reference genome databases for profiling metagenomics data. However, many eukaryotic genomes contain regions with high sequence similar
Non-technical summary. As glaciers shrink and disappear, the benefits they provide to people may also be fading. This makes it more important than ever to look closely at how melting glaciers affect both the environment and the communities that depend on them. To truly understand what is being lost- or even gained- we need to study glaciers from many angles. This includes looking at the science of
Surface tension is crucial for nanowire vapor liquid solid (VLS) growth models and simulations of growth under external stimuli. A promising method involving imaging droplet deformation under an external electric field has previously been used to report the surface tension of the AuSi eutectic catalyst on Si-nanowires. However, simplified assumptions in this approach led to a significantly lower v
The extensive genetic diversity of HIV-1 represents a major challenge to public health interventions, treatment, and successful vaccine design. This challenge is particularly pronounced in the Middle East and North Africa (MENA) region, where limited data among other barriers preclude the accurate characterization of HIV-1 genetic diversity. The objective of this review was to analyze studies cond
Objective To investigate the effect of Body Mass Index (BMI) on long-term radiographic damage in an inception rheumatoid arthritis (RA) cohort. Methods The study population, n=1813, originated from the observational Better AntiRheumatic FarmacoTherapy cohort. X-rays of hands and feet at inclusion, 1, 2, 5, 8 and 15 years were quantified for erosion score (ES), joint space narrowing (JSN) and the s
