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A concise and enantioselective total synthesis of the Veratrum alkaloid cyclopamine is disclosed. This highly convergent synthesis with a 16-step longest linear sequence (LLS) was enabled by a de novo synthesis of the trans-6,5-heterobicycle via a strain-inducing halocyclization process, a key Tsuji–Trost cyclization to construct the fully substituted, spirocyclic THF motif with exquisite diast
Abstract There is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. Herein a uniquely powerful and simple set of conditions for achieving this transformation with unparalleled generality and chemoselectivity is disclosed. This new protocol is placed in context with other recently rThere is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to (hetero)aryl halides. Herein a uniquely powerful and simple set of conditions for achieving this transformation with unparalleled generality and chemoselectivity is disclosed. This new protocol is placed in context with other recently report
OBJECTIVES: To compare patient reported outcomes from before surgery to 52 weeks after surgery between individuals undergoing arthroscopic partial meniscectomy for traumatic meniscal tears and those for degenerative meniscal tears.DESIGN: Comparative prospective cohort study.SETTING: Four public orthopaedic departments in the Region of Southern Denmark. Participants were recruited between 1 Februa
Objectives: This study sought to examine the relationship between temperature at reperfusion and infarct size. Background: Hypothermia consistently reduces infarct size when administered prior to reperfusion in animal studies, however, clinical results have been inconsistent. Methods: We performed a patient-level pooled analysis from six randomized control trials of endovascular cooling during pri
This paper focuses on the interaction of reasons and argues that reasons for an action may transmit to the necessary means of that action. Analyzing exactly how this phenomenon may be captured by principles governing normative transmission has proved an intricate task in recent years. In this paper, I assess three formulations focusing on normative transmission and necessary means: Ought Necessity
Catchy slogans about tourism’s peace-promoting qualities abound—‘passport to peace’, ‘a vital force for peace’, and ‘the peace industry’, to name but a few. Yet, despite the critical scrutiny of the peace–tourism nexus in recent decades, its historical origins remain unexplored. This article traces the historical roots of the idea that tourism can help advance peace and international understanding
Ecosystem functioning depends on biodiversity at multiple trophic levels, yet relationships between multitrophic diversity and ecosystem multifunctionality have been poorly explored, with studies often focusing on individual trophic levels and functions and on specific ecosystem types. Here, we show that plant diversity can affect ecosystem functioning both directly and by affecting other trophic
This article takes a cognitive approach to natural concepts. The aim is to introduce criteria that are evaluated with respect to how they support the cognitive economy of humans when using concepts in reasoning and communicating with them. I first present the theory of conceptual spaces as a tool for expressing the criteria. Then I introduce the central idea that natural concepts correspond to con
Probabilistic life-cycle consequence (LCCon) analysis (e.g., assessment of repair costs, downtime, or casualties over an asset's service life) can enable optimal life-cycle management of critical assets under uncertainties. This can lead to effective risk-informed decision-making for future disaster management (i.e., risk mitigation and/or resilience-enhancing strategies/policies) implementation.
The low water flux and high production cost of ceramic membranes for vacuum membrane distillation (VMD) are among the factors limiting their feasibility for desalination applications. To address this challenge, highly permeable anodic alumina membranes were modified and evaluated for their properties in VMD using a highly permeable support. Owing to the nanostructures on its surface, the anodic al
This study proposes to determine the influence of ‘Environmental Knowledge’ (EK), ‘Altruism’ (Atr), ‘Consumer Confidence’ (CC) and constructs of ‘Theory of Planned Behaviour’ (TPB) like Attitude” (Atd), ‘Subjective Norm’ (Sub) and ‘Perceived behavioural control’ (Pbhc) on consumers’ intention to purchase ‘Green Apparel Products’ (GAPI). Moreover, the moderating effect of ‘Perceived Innovativeness’
BackgroundTo enable people with stroke to achieve an active everyday life under altered conditions, the development of self-management programs is essential to facilitate the process of change that individuals must undergo. To improve access to self-management, internet-based solutions have been proposed. The aim of this study was to evaluate the feasibility of a novel internet-based intervention,
Existentiella hot, inklusive hot mot jaget, samhället och planeten, förekommer genom hela livet och utgör en central del av den mänskliga erfarenheten. För att sammanföra kunskap och begrepp om hur människor kan hantera existentiella hot på ett adekvat sätt sammankallade vi en tvärvetenskaplig arbetsgrupp bestående av åtta forskare från fälten psykologi, systematisk teologi, praktisk teologi, reliExistential threats, including threats to the self, society, and the planet, are present throughout the lifespan and form a core element of the human experience. To consolidate knowledge and constructs about how people can adequately respond to existential threats, we convened an interdisciplinary working group, which consisted of eight researchers from the fields of psychology, systemic theology,
1911 beslöt stadsfullmäktige i Malmö enhälligt och utan debatt att införa en kommunal bostadsinspektion. I denna artikel undersöks bostadsinspektionens härkomst genom att följa olika problematiseringar som inspektion sades lösa hos stadens förvaltningar, den lokala arbetarrörelsen och Fredrika-Bremerförbunds-kretsen i Malmö. Undersökningen visar att urbana aktörer som delvis befann sig utanför parIn 1911 the Swedish city of Malmö got its first housing inspection service. It was put forward in a motion by two social-democratic city councillors and supported by conservative councillors as well as by the women’s movement. The vote in the city council passed unanimously and without discussion. This article focuses on how the question of housing was articulated in a way that meant inspections w
Background: Myocardial infarction (MI) is a serious condition that increases with age. It is valuable to identify the reasons why some are affected, and possibly, why different personality traits can be associated with an increased or decreased risk for myocardial infarction. Methods: This is a cross-sectional study based on wave 7 data from the Survey of Health, Ageing and Retirement in Europe (S
Lysozyme is a model system for crystallographers. In this issue of Structure, Ramos et al. report atomic resolution neutron structures of lysozyme, which unambiguously show the protonation states and hydrogen-bonding networks of the active site. This resolves mechanistic questions that have been debated for decades and provides a unique view to a protein at atomic detail.
To address the challenges of energy transition necessary for sustainable development, incumbents must implement innovations, some of which are radical compared with their current competence-base or market solutions. This requires a thorough understanding of the prerequisites for implementing innovation. The literature on the factors influencing incumbents' implementation is vast and dispersed acro
OBJECTIVES: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive adjunct to multimodal pain management for acute postoperative care across various surgeries. Despite extensive evidence supporting its efficacy, TENS remains underutilized in clinical practice. This study aimed to assess the knowledge, attitudes, and practices of healthcare professionals regarding TENS in perioperative
