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Transfusion-related acute lung injury (TRALI) is a life-threatening complication of acute respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells appear to be important for p
Chemistry and kinematic studies can determine the origins of stellar population across the Milky Way. The metallicity distribution function of the bulge indicates that it comprises multiple populations, the more metal-poor end of which is particularly poorly understood. It is currently unknown if metal-poor bulge stars ([Fe/H] <−1 dex) are part of the stellar halo in the inner most region, or a di
A steady increase in the incidence of osteoarthritis and other rheumatic diseases has been observed in recent decades, including autoimmune conditions such as rheumatoid arthritis, spondyloarthropathies, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome. Rheumatic and autoimmune diseases (RADs) are characterized by the inflammation of joints, muscles, or other connective tis
Researchers trialing behavioral interventions often use attention control groups, but few publish details on attention control activities or perceived benefit. Attention control groups receive the same dose of interpersonal interaction as intervention participants but no other elements of the intervention, to control for the benefits of attention that may come from behavioral interventions. Becaus
Finns det organisatoriska och finansiella faktorer som påverkar VA-organisationernas förmåga att planera och genomföra investeringar? En undersökning av budget och utfall för VA-investeringar åren 2015−2017 och planerade investeringar för åren 2018−2021 visar att det är viktigt att det fi nns god tillgång på kompetens i kommunen samt att mindre kommuner drar fördel av att samverka.
In this study the strain rate effects on the tensile and compressive properties of nano-crystalline nanoporous gold (nc-NPAu) are investigated by performing molecular dynamics simulations. In order to examine the role of strain rate,atomistic models of nc-NPAu structures with three different grain size are generated through a novel modeling technique based on the Voronoi tessellation method. AdditIn this study, strain rate effects on the tensile and compressive properties of nano-crystalline nanoporous gold (nc-NPAu) are investigated by performing molecular dynamics simulations. For this purpose, atomistic models of nc-NPAu structures with three different grain sizes are generated through a novel modeling technique based on the Voronoi tessellation method. Additionally, an adaptive common
Three dimensional molecular dynamics (MD) is used to model the mechanical response at the interface between a thin Cu coating resting on a base of Si. The copper coating is subjected to a displacement controlled shear load and the atom movements at the Si-Cu interface are monitored to investigate the effects of crystallographic anisotropy. The two crystals have the same crystallographic orientatio
Here we investigate the influence from a centrally placed grain boundary in nano-sized beams of Cu subjected to tensile loading normal to the grain boundary. Also the influence of the cross section size of the beams are investigated. The crystallographic orientations in the grains are [100], [110] or [111], and the results are compared to those of single crystal beams. The investigation is perform
BACKGROUND: Iron deficiency in polycythaemia vera (PV) may impact the validity of the haematocrit (HCT), since HCT is red blood cell count (RBC) × mean corpuscular volume (MCV).OBJECTIVES: To investigate (a) the effect of microcytosis on HCT, (b) the erythrocyte sedimentation rate (ESR) as a possible additional diagnostic marker for PV.MATERIAL AND METHODS: This study included 182 subjects: 39 wit
A number of anti-tumor necrosis factor alpha (TNF-α) biologics have been developed in recent years, such as adalimumab, etanercept, and infliximab for the treatment of chronic inflammatory disorders like rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis and several other novel drugs that target TNF-α signaling are still being developed. Indeed, blockade of this pathway see
Use of image-guided radiation therapy (IGRT) helps to account for daily prostate position changes during radiation therapy for prostate cancer. However, guidelines for the use of IGRT are scarce. An ESTRO panel consisting of leading radiation oncologists and medical physicists was assembled to review the literature and formulate a consensus guideline of methods and procedure for IGRT in prostate c
Standard treatment for glioblastoma (GBM) patients is surgery and radiochemotherapy (RCT) with temozolomide (TMZ). TMZ is a substrate for ABCB1, a transmembrane drug transporter. It has been suggested that survival for GBM patients receiving TMZ is influenced by different single-nucleotide variants (SNV) of ABCB1. We therefore examined SNV:s of ABCB1, namely 1199G>A, 1236C>T, 2677G>T/A, and 3435C>
Historik över rektorsämbetet vid Lunds universitet.
Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proTo date, bone marrow-derived mesenchymal stromal cells (MSCs) have been considered the golden standard among MSC cell-based therapies. However, the harvesting of bone marrow is a highly invasive procedure and the number of MSCs isolated is low, and it declines with increasing age. MSCs with immune-regulatory and regenerative properties can be isolated from many different tissues; however, bone mar
Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proChronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies pro
