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Nanofluidic gas/liquid switching utilizing a nanochannel open/close valve based on glass deformation

There has been much progress in the field of nanofluidics, and novel applications, such as single-cell analysis, have been achieved. In such cases, controlling the location of the gas/liquid interface is vital and partial hydrophobic modification is frequently used to pin the position of this interface. However, because the fluid manipulating pressure in such devices is comparable to the Laplace p

Mission-Oriented Innovation Districts : Towards challenge-led, place-based urban innovation

In recent years, there has been rapidly growing interest in Innovation Districts (ID) in urban policy and practice. IDs are touted as catalysts for innovation and economic development involving a wide range of stakeholders often in under-performing neighbourhoods or precincts. Despite the appeal, critique is forming around their linear understanding of innovation, the narrow focus of economic goal

Modeling the choice of shared micro-mobility services using XGBoost machine learning

In recent years, shared micro-mobility services (e.g., bikes, e-bikes, and e-scooters) have been popularized at a rapid pace worldwide, which provide more choices for people’s short and medium-distance travel. Accurately modeling the choice of these shared micro-mobility services is important for their regulation and management. However, little attention has been paid to modeling their choice, esp

Improved Estimation of Key Enumeration with Applications to Solving LWE

In post-quantum cryptography (PQC), Learning With Errors (LWE) is one of the dominant underlying mathematical problems. For example, in NIST’s PQC standardization process, the Key Encapsulation Mechanism (KEM) protocol chosen for standardization was Kyber, an LWE-based scheme. Recently the dual attack surpassed the primal attack in terms of concrete complexity for solving the underlying LWE proble

Interface engineering of cellobiose dehydrogenase improves interdomain electron transfer

Cellobiose dehydrogenase (CDH) is a bioelectrocatalyst that enables direct electron transfer (DET) in biosensors and biofuel cells. The application of this bidomain hemoflavoenzyme for physiological glucose measurements is limited by its acidic pH optimum and slow interdomain electron transfer (IET) at pH 7.5. The reason for this rate-limiting electron transfer step is electrostatic repulsion at t

In-situ electrochemical synthesis of heteroatoms-doped reduced graphene oxide toward nonradical degradation of tetracycline

Nonradical-based advanced oxidation processes (AOPs) catalyzed by defective carbonaceous materials have exhibited great superiorities in trace antibiotics removal from natural water matrices. However, the complicated, extensive and highly-energy consumed synthesis methods are seriously hindering its development and application. Herein an in-situ electrochemical synthesis technology was developed a

Do Not Bound to a Single Position: Near-Optimal Multi-Positional Mismatch Attacks Against Kyber and Saber

Misuse resilience is an important security criterion in the evaluation of the NIST Post-quantum cryptography standardization process. In this paper, we propose new key mismatch attacks against Kyber and Saber, NIST's selected scheme for encryption and one of the finalists in the third round of the NIST competition, respectively. Our novel idea is to recover partial information of multiple secret e

Seasonal variations in acidogenic fermentation of filter primary sludge

Primary treatment of municipal wastewater by rotating belt filtration followed by hydrolysis and acidogenic fermentation of the filter primary sludge (FPS) at ambient temperature was studied at pilot-scale during one year. The seasonal variations of volatile fatty acids (VFAs), nutrient release and soluble COD production as well as microbial community assembly were assessed, leading to novel findi

Belief Propagation Meets Lattice Reduction: Security Estimates for Error-Tolerant Key Recovery from Decryption Errors

In LWE-based KEMs, observed decryption errors leak information about the secret key in the form of equations or inequalities. Several practical fault attacks have already exploited such leakage by either directly applying a fault or enabling a chosen-ciphertext attack using a fault. When the leaked information is in the form of inequalities, the recovery of the secret key is not trivial. Recent me

Dual-amplification system based on CRISPR-Cas12a and horseradish peroxidase-tethered magnetic microspheres for colorimetric detection of microcystin-LR

A novel dual-amplification system based on CRISPR-Cas12a and horseradish peroxidase (HRP) was developed for colorimetric determination of MC-LR. This dual-amplification was accomplished by combining the nuclease activity of CRISPR-Cas12a with the redox activity of HRP. HRP linked to magnetic beads through an ssDNA (MB-ssDNA-HRP) was used to induce a color change of the 3,3′,5,5′-tetramethylbenzidi

Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine

The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been mi

Impact of metabolic substrate modification on myocardial efficiency in a rat model of obesity and diabetes

BackgroundCongenic leptin receptor deficient rat generated by introgression of the Koletsky leptin receptor mutation into BioBreeding Diabetes Resistant rat (BBDR.lepr−/−) is a novel animal model combining obesity, systemic insulin resistance and diabetes. Systemic insulin resistance is associated with reduced myocardial glucose utilization, but its effect on myocardial external efficiency, i.e. t

Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus : A randomized trial

Background & aims: Short telomeres have been observed in chronic disease patients. Identifying environmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 3

Systems perspectives on combined production of advanced biojet fuel and biofuels in existing industrial infrastructure in Sweden

This paper assesses the opportunities for resource- and energy-efficient biojet fuel production from forest-based biomass utilising existing industrial infrastructure in Sweden. Two categories of production pathways are considered: one including technologies that are certified for the production of biojet fuel, and the other uncertified technologies under development. Aspects included are producti

Changes in Practice of Controlled Hypothermia after Cardiac Arrest in the Past 20 Years : A Critical Care Perspective

For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initi