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This paper presents a biocatalysis based approach for asymmetric hydrolysis of Clopidogrel, one of the most effective antiplatelet aggregators. Instead of the conventional "wet lab" screening method, we used an advanced chemical information retrieval tool, Scifinder®, to find suitable enzyme candidate(s) for the asymmetric hydrolysis. Scifinder® search for reactions similar to the target reaction
The laccase producing fungus HC1 was isolated from a sample collected in the Bolivian Amazon region. Analysis of 5.8S and 28S rDNA, and internal transcribed spacer 1 and 2 sequences revealed that isolate HC1 belongs to genus Galerina. High production of laccase was achieved in basal salt medium supplemented with 30 g L-1 glucose, 10 g L-1 yeast extract and 0.01 g L-1 copper sulphate. The enzyme pr
This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field
Batch cultures with wheat straw, biomass of Paja Brava (Festuca orthophylla), filter paper, newspaper and beech leaves (Fagus sylvatica) were established to produce sulphide. Sulphide production, sulphate reduction, concentration of Volatile Fatty Acids (VFAs), enzyme activities and Fluorescence in situ hybridisation were determined. Approximately 5 mM of sulphide was produced during anaerobic dig
Background: Smoking is a strong risk factor for cardiovascular disease (CVD) and causes exposure to cadmium, which is a pro-atherosclerotic metal. Cadmium exposure has also been shown to increase the risk of CVD, even after adjustment for smoking. Our hypothesis was that part of the risk of CVD in smokers may be mediated by cadmium exposure from tobacco smoke. We examined this hypothesis in a medi
We report on phase-coherent transport studies of a Bi2O2Se nanoplate and on observation of universal conductance fluctuations and spin-orbit interaction induced reduction in fluctuation amplitude in the nanoplate. Thin-layered Bi2O2Se nanoplates are grown by chemical vapor deposition (CVD) and transport measurements are made on a Hall-bar device fabricated from a CVD-grown nanoplate. The measureme
Background: Earlier nonrandomized studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous compared with open distal pancreatectomy (ODP) regarding hospital stay, blood loss, and recovery. Only one randomized study has been conducted showing reduced time to functional recovery after LDP compared with ODP. Methods: LAPOP is a prospective randomized, nonblinded, parallel-
The precarious situation faced by women and girls in the wake of climate-related disasters is illustrated through fieldwork conducted in Eastern Visayas in the Philippines, one of the regions most affected by Super Typhoon Haiyan in 2013. However, this article illustrates that these heightened levels of gendered violence faced by women and girls are not a result of the disaster alone; rather, they
Primary Sjögren’s syndrome (pSS) is an autoimmune disease, primarliy affecting women, characterised by inflammation and destruction of exocrine glands with a prevalence of 0.01-0.09%. About one-third of the patients also suffer from extraglandular manifestations e.g. inflammation in the lungs, kidneys, skin or nerves. Apart from dyness symptoms, patients often suffer from fatigue and pain. Little
Patient-reported outcomes but not Demographic Factors Predict Normal Muscle Function 2-5 Years After ACL Injury: A Cross-Sectional StudyNiklas Cederström1, Ewa Roos2, Eva Ageberg1(1)Musculoskeletal Function Research Group, Department of Health Sciences, Faculty of Medicine, Lund University(2)Institute of Sport Science and Clinical Biomechanics, Musculoskeletal Function and Physiotherapy, Universit
This paper presents a framework developed for an industrial robotics system that utilises two different planning components. At a high level, a multi-robot mission planner interfaces with a fleet and environment manager and uses multiagent planning techniques to build mission assignments to be distributed to a robot fleet. On each robot, a task planner automatically converts the robot's world mode
