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Summary: Codon sequences can influence proteins to misfold during cotranslational folding. Here, we develop an in vivo assay in E. coli to comprehensively study the impact of single synonymous substitutions on protein folding efficiency and apply it to the N-terminal domain of ddlA. By mapping the influence of codons along the sequence, we show that codon identity can substantially influence foldi
The North Atlantic region is a key component of the climate system via large-scale atmosphere and ocean circulation. Climate field reconstructions can provide a long-term context for ongoing climate change and contribute to our understanding of climate dynamics, impact of external forcings, and act as references for model evaluation and baseline for natural variability. There are distinct differen
During the investigations within the Vestfoldbane excavation project, c. 1000 sherds of Neolithic pottery were found at Langangen Vestgård 6, Figure 1 (Reitan 2014a). This pottery is classified as Funnel Beaker type. Both radiocarbon and shoreline dating are in accordance with the typological dating, c. 3900-3600 BC (all dates in this article are in calBC). When the site was in use, it was close t
For multi-vehicle complex traffic scenarios in shared spaces such as intelligent intersections, safe coordination and trajectory planning is challenging due to computational complexity. To meet this challenge, we introduce a computationally efficient method for generating collision-free trajectories along predefined vehicle paths. We reformulate a constrained minimum-time trajectory planning probl
Abstract – Introduction: Somatic symptom disorder (SSD) is associated with substantial impairment and high healthcare use, particularly among patients with chronic symptoms, psychiatric comorbidity, and poor response to standard interventions. Intensive short-term dynamic psychotherapy (ISTDP) is a promising emotion-focused approach, but evidence in treatment-resistant SSD remains limited. Methods
Background – Advancing the development of highly efficacious and long-lasting malaria vaccines is hampered by incomplete knowledge of protective immune mechanisms and an absence of established correlates of immunity. Antibody avidity is frequently evaluated as an indicator of a high-quality or protective antibody response to vaccination. However, the importance of avidity in vaccine-induced immuni
Many Japanese regional cities face population decline, industrial constraints, and limited resources for decarbonization, yet hold untapped potential in the residential and commercial sectors through local energy use. This chapter develops a carbon neutrality (CN) strategy for Tochigi Prefecture and evaluates its feasibility with particular attention to social acceptance. Six scenarios were create
Absorption of chemicals through the skin affects occupational and environmental exposure to diverse compounds. We previously showed that loss-of-function (null) mutations and low–copy number variants (CNV) of Filaggrin (FLG), which encodes a key skin barrier protein, increased dermal chemical absorption; however, the FLG genotype did not explain all the observed variation. Here, we explore the eff
The initiation of adaptive immunity requires antigen presentation in immune inductive sites. Classical dendritic cells (cDC) sense peripheral immune response inducing cues and migrate to the tissue-draining lymph nodes upon engagement, where they present acquired antigen to cognate T cells. Vaccines include adjuvants, which enable cDC activation and migration, both essential steps in the cascade l
Background: Complex endovascular repair has emerged as a minimally invasive alternative for thoracoabdominal aortic aneurysms (TAAAs). The aim of this study was to assess the short- and mid-term outcomes of endovascular TAAA repair in Sweden. Methods: All endovascular TAAA repairs performed during 2018–2023 were identified in the Swedish Vascular (Swedvasc) Registry. Patient characteristics, opera
Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this multicellular immune network remain largely elusive. This review
Additive manufacturing enables multi-material functionally graded materials (FGMs) with expanded functionality, yet post-machining remains challenging because flow stress varies with composition. This paper presents a data-efficient, physics-guided Gaussian process (GP) model for predicting milling forces in SS316/IN718 FGMs without repeated force-coefficient identification. A physics-based millin
Background: Limonene and linalool are fragrance terpenes that undergo autoxidation to sensitizing hydroperoxides. This study assessed the penetration of limonene hydroperoxide and linalool hydroperoxide from patch test preparations in ex vivo human skin samples, alongside analysing the effects of the patch test preparations on the composition of skin lipids, using Time-of-Flight Secondary Ion Mass
Biodiversity offsetting (BO) is a neoliberal conservation policy formulated in international policy arenas and later integrated into national policies in several countries. Studies of BO policy have shed light on diverse social and environmental justice concerns on the local levels of policy implementation. However, much of the research on justice questions in BO has centred on the distribution of
Despite intense investigation through centuries, there is still no scientific consensus on how to describe myocardial microarchitecture. This is mainly because the myocardium must be visualised in three dimensions, and with sufficiently high resolution to fully appreciate its complex nature. X-ray microtomography allows for exactly such visualisation. Using this technique, we herein provide a desc
Background: The global energy transition toward climate neutrality is driving rapid growth in the demand for critical minerals such as lithium, cobalt, and nickel. While indispensable for decarbonization, their extraction, processing, and recycling expose workers, communities, and ecosystems to toxic metals, including lead, mercury, arsenic, cadmium, and manganese, raising significant public healt
Objectives: Although obsessive-compulsive disorder (OCD) is strongly associated with a range of modifiable somatic health problems, little is known about how the disorder influences the adoption and maintenance of healthy lifestyle habits, as well as how it shapes patients' experiences of seeking and receiving general healthcare. Methods: Sixteen individuals with OCD and cardiometabolic risk who p
We transform large-scale Swedish register data into textual life trajectories to address two long-standing challenges in data analysis: high cardinality of categorical variables and inconsistencies in coding schemes over time. Leveraging this uniquely comprehensive population register, we convert register data from 6.9 million individuals (2001–2013) into semantically rich texts and predict indivi
Historians as well as sociologists of higher education by now agree that European supranational policies and processes of European integration dramatically changed European universities during the last quarter of the 20th century—often calling this a process of “Europeanisation”. But how and when did this Europeanisation start, which ideas and ambitions for Europe did it entail, and what did the t
