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BACKGROUND: Exertional breathlessness is a major symptom in cardiorespiratory disease and is often assessed using the modified Medical Research Council (mMRC) questionnaire. The mMRC might underestimate exertional breathlessness in people with impaired exercise capacity who have reduced their physical activity to avoid the symptom. We aimed to evaluate the ability of mMRC to detect abnormally high
The plasma proteome is maintained by the influx and efflux of proteins from surrounding organs and cells. To quantify the extent to which different organs and cells impact the plasma proteome in healthy and diseased conditions, we developed a mass-spectrometry-based proteomics strategy to infer the tissue origin of proteins detected in human plasma. We first constructed an extensive human proteome
Surgical systems are complex and susceptible to external system pressures. The SARS-CoV-2 pandemic and its impact on elective surgery illustrated this. The reassignment of resources to the acute care of patients with COVID-19 led to cancellations of elective services that varied according to surges of the pandemic. Overall, it was estimated that more than 28 million operations were cancelled or po
Background: The occupational therapy intervention Balancing Everyday Life (BEL)TM aims to support mental health service users towards improved occupational balance and personal recovery. Yet, no research has specifically addressed recovery experiences among BELTM participants. Aim: To investigate how the recovery process was experienced by mental health services users who had participated in BELTM
Objectives: In this nationwide cohort study in a Scandinavian setting, we aimed to investigate the magnitude of association between flucloxacillin use and drug-induced liver injury (DILI). Methods: Nationwide cohort study among adults in Sweden, 2006–2018, was conducted. Register data on filled prescriptions, patient characteristics, co-medications, and DILI were linked. All filled prescriptions f
Background: COVID-19 caused a profound global impact, resulting in significant cases and deaths. The progression of COVID-19 clinical manifestations is influenced by a dysregulated inflammatory response. Early identification of the subclinical progression is crucial for timely intervention and improved patient outcomes. While there are various biomarkers to predict disease severity and outcomes, t
Background: Extended reality (XR), encompassing technologies such as virtual reality, augmented reality, and mixed reality, has rapidly gained prominence in health care. However, existing XR research often lacks rigor, proper controls, and standardization. Objective: To address this and to enhance the transparency and quality of reporting in early-phase clinical evaluations of XR applications, we
Health is multifaceted, with divergent interpretations in diverse cultures and groups of individuals. The ways individuals understand health might aid in developing future interventions. There is scant knowledge on how adolescents with depression conceptualise health. A descriptive qualitative design with a phenomenographic approach was used to describe the different ways adolescents with depressi
Denna studie undersöker hur restid upplevs och används av kollektivtrafikresenärer. Genom en enkät med drygt tusen respondenter och samtal i en fokusgrupp framkommer flera intressanta insikter.Mobiltelefonen har blivit den mest använda utrustningen ombord, medan traditionella medier som böcker och tidningar har minskat i förekomst. Vanliga aktiviteter under resan inkluderar att scrolla på mobilen,This study examines how travel time is perceived and utilised by public transport passengers. Through a survey of just over a thousand respondents and discussions in a focus group, several interesting insights emerge.The mobile phone has become the most used device on board, while traditional media such as books and newspapers have decreased in prevalence. Common activities during the journey incl
INTRODUCTION: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear. METHOD: Longitudinal demographics, T1-weighted magnetic resonance imaging (MRI), and cognitive scores of 3036 cognitively unimpaired (CU) older adults (amyloid beta [Aβ]-negative
This article presents new estimates of the material living standards among the rural population in southern Sweden from the 1670s up to 1865. The development of rural consumer patterns over the period is analyzed using a newly constructed database of 1665 probate inventories from three benchmark periods. It finds that that all rural households, no matter their socioeconomic status, diversified theThis article presents new estimates of the material living standards among the rural population in southern Sweden from the 1670s up to 1865. The development of rural consumer patterns over the period is analyzed using a newly constructed database of 1665 probate inventories from three benchmark periods. It finds that that all rural households, no matter their socioeconomic status, diversified the
Capturing ultrafast phenomena requires imaging techniques capable of resolving events occurring on femtosecond time scales. Traditional high-speed cameras are limited by electronic readout speeds and cannot reach the terahertz (THz) frame rates necessary to observe processes such as laser filamentation, plasma formation, or light-matter interactions in general. To overcome these limitations, this
BackgroundSexual violence is widespread in the eastern parts of the Democratic Republic of the Congo, including in the North Kivu province. Moreover, in this region survivors of sexual violence often have limited access to care and encounter a variety of barriers when seeking care and support. The aim of this study was to explore community perceptions about access to care, barriers, enablers and pBackgroundSexual violence is widespread in the eastern parts of the Democratic Republic of the Congo, including in the North Kivu province. Moreover, in this region survivors of sexual violence often have limited access to care and encounter a variety of barriers when seeking care and support. The aim of this study was to explore community perceptions about access to care, barriers, enablers and p
Aim: Self-reported cognitive function has been described as an important complement to performance-based measurements but has seldom been investigated in cardiac arrest (CA) survivors. Therefore, the aim was to describe self-reported cognitive function and its association with health status, psychological distress, and life satisfaction.Methods: This study utilised data from the Swedish Register oAim: Self-reported cognitive function has been described as an important complement to performance-based measurements but has seldom been investigated in cardiac arrest (CA) survivors. Therefore, the aim was to describe self-reported cognitive function and its association with health status, psychological distress, and life satisfaction. Methods: This study utilised data from the Swedish Register
BACKGROUND: Congenital Cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is yet not well understood, and follow-up studies on adults screened for CMV at birth are few. The aim of this study was to investigate self-reported executive functioning
The first years of life are a critical period of development, and circumstances during this period can affect individuals throughout life. But to what extent do disadvantaged circumstances in childhood affect individual wellbeing in later life and for whom? Can interventions in childhood break adversity over the life course? For whom are interventions most effective and why?This thesis aims to invThe first years of life are a critical period of development, and circumstances during this period can affect individuals throughout life. But to what extent do disadvantaged circumstances in childhood affect individual wellbeing in later life and for whom? Can interventions in childhood break adversity over the life course? For whom are interventions most effective and why? This thesis aims to in
Poly-N-isopropylacrylamide (PNIPAM) microgels are versatile colloidal-scale polymer networks that exhibit unique responsiveness to external stimuli, such as temperature. While the synthesis of PNIPAM microgels is well-documented, there is limited exploration of how their structural properties can be modified by subtle changes in the polymerization process. In this work, we carefully investigate ho
