PURPOSE: Galectin-3, a β-galactoside-binding lectin, plays a key role in several cellular pathways involved in chronic inflammation, heart disease and cancer. GB1211 is an orally bioavailable galectin-3 inhibitor, developed to be systemically active. We report safety and pharmacokinetics (PK) of GB1211 in healthy participants.METHODS: This phase 1, double-blind, placebo-controlled, first-in-human

This chapter delves into the challenges encountered by victims of human trafficking and other forms of labour exploitation in Sweden as they struggle to access social rights and justice. By drawing from theories of victimisation as an interactional process, the study examines the role of professionals such as government agents, social services, unions, and NGOs as facilitators in assisting victimsThis chapter delves into the challenges encountered by victims of human trafficking and other forms of labour exploitation in Sweden as they struggle to access social rights and justice. By drawing from theories of victimisation as an interactional process, the study examines the role of professionals such as government agents, social services, unions, and NGOs as facilitators in assisting victims

PURPOSE: To investigate acute and long-term changes in hormonal and inflammatory biomarkers in nonambulant children with cerebral palsy in response to dynamic standing exercise.METHODS: Fourteen children with severe cerebral palsy were recruited. Anthropometrics and body composition measures were obtained. Physical activity levels before the study were assessed using hip-worn accelerometry. All ch

INTRODUCTION: Regular physical activity confers health benefits for all. Parents commonly want their children to be physically active, and want to be physically active themselves, but children with cerebral palsy (CP) who are non-ambulant face challenges, and they need support to be physically active. Dynamic standing in the novel motorized assistive device Innowalk has positive effects in childre

Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress re

This contribution analyses the external dimensions of the EU’s autocracy crisis. It argues that the internal and external dimensions of the crisis, and those relating to accession, are interlinked, and that more genuine social democracy, human rights, and rule of law would help address the crisis. It concludes that a paradigm shift to a holistic approach is needed to understand and address the cau

Gradient-based optimization is a potent tool in many design processes today. It is particularly useful in industries where weight considerations are crucial, such as aerospace, but can also be exploited in for example civil engineering applications to reduce the material use and thereby the environmental impact. With the advent of advanced manufacture methods, it even possesses the potential to de

The human vestibulo-ocular reflex (VOR) leads to maintenance of the acuity of an image on the retina and contributes to the perception of orientation during high acceleration head movements. Our objective was to determine whether vision affects the horizontal VOR by assessing and comparing the performance at the boundaries of contribution of: (a) unrestricted visual information and (b) no visual i

The demand for energy security and reduction of greenhouse gas emissions has led to a surge of interest in the development of high-efficiency and low-emission gas turbine engines that can run on alternative low carbon content fuels, such as hydrogen-enriched fuel and syngas. However, the combustion characteristics of these fuels can significantly alter the flame characteristics and operability ran

Dissolved organic matter (DOM) is considered the most bioavailable fraction of soil, and thus play a key role in the cycling of carbon. Because of its mobility, DOM also forms the connection between terrestrial and aquatic systems, and constitutes an important vector for nutrients and contaminants. DOM is in this thesis operationally defined as the organic matter in an aqueous solution which is no

Human activities in coastal areas have intensified over the last 200 years, impacting also high-latitude regions such as the Baltic Sea. Benthic foraminifera, protists often with calcite shells (tests), are typically well preserved in marine sediments and known to record past bottom-water conditions. Morphological analyses of marine shells acquired by microcomputed tomography (µCT) have made signi

I denna rapport redovisas populationstrender för 224 svenska fågelarter för olika långa tidsperioder, samt korttidstrender för 12 arter av större däggdjur. Fåglarna har räknats höst, vinter, vår och sommar enligt strikt standardiserade metoder. Sommar- respektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren (sedan 1996)men täcker hWe present the results of the Swedish Bird Survey, a project run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2022 include data from: 546 winter point counts in 2021/2022 (47th winter), ofwhich 254 were carried out during the Christmas/New Year count, 209 summer point count routes (48th

High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generall

Machine learning (ML) methods have shown noteworthy skill in recognizing environmental patterns. However, presence of weather noise associated with the chaotic characteristics of water cycle components restricts the capability of standalone ML models in the modeling of extreme climate events such as droughts. To tackle the problem, this article suggests two novel hybrid ML models based on combinat