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Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicatin
The Middle Darriwilian Isotopic Carbon Excursion (MDICE) is one of the globally recognized positive excursions in carbon isotope chemostratigraphy, but mainly documented by δ13Ccarb data in previous research. In this paper, new stable organic carbon isotope data (δ13Corg) are presented from the Hule-1 core from the southern Anhui Province of southern China. The core constitutes an Ordovician silic
Background: Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort. Methods: This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50–64 years, n = 8,957). Sodium
Traditional methods for microbial water quality testing take up to two days to produce results, putting humans in contact with this water risk during this period. Flow cytometry, including with online capacity, is a fast and efficient way to profile microbes in water. In this study, Escherichia coli concentrations determined by Colilert18 and flow cytometry profiles from the same water samples wer
Purpose of Review: This review synthesizes current knowledge of the aggregation pheromones of Ips bark beetles specialized on coniferous hosts. The pest potential of these insects is increasing globally due to climate change and anthropogenic disturbances. The high aggressiveness of some species results from coordinated mass attacks on trees, mediated by male-produced aggregation pheromones. Bring
Electric buses are increasingly popular in public transport systems globally, and in many European contexts, this transition takes place through public procurement. While previous research argues that electrification challenges existing procurement practices and strategies, the aim of the paper is to contribute new knowledge on the role of public procurement in the transition to electric buses andElectric buses are increasingly popular in public transport systems globally, and in many European contexts, this transition takes place through public procurement. While previous research argues that electrification challenges existing procurement practices and strategies, the aim of the paper is to contribute new knowledge on the role of public procurement in the transition to electric buses and
Telomerase plays an important role in sustaining eukaryotic linear chromosomes, as elongation of telomeres is needed to counterbalance the shortening occurring in each replication round. Nevertheless, in telomerase-deficient cells, Alternative Lengthening of Telomeres (ALT) pathways can maintain telomeres by employing recombination-based mechanisms. In the budding yeast Naumovozyma castellii, effe
A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [18F]-metafluorobenzylguanidine (mFBG), [68Ga]Ga-DOTA-TOC and [18F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [123I]-metaiodobenzylguanidine (mIBG). The methods
Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was
Black carbon (BC), a major component of fine particulate matter (PM2.5), has been implicated in adverse neurodevelopmental outcomes, including autism spectrum disorders (ASD). While PM2.5 has been associated with increased ASD risk, the specific role of BC remains uncertain. This study aimed to assess prenatal exposure to BC and risk for ASD development in a low exposure setting, using a large, hi
Temperature impacts on microbiological processes are crucial for soil biogeochemistry and ecosystem functioning, yet existing models either fail to capture microbial temperature dependences across the full biokinetic range or risk overparameterization. Here we present the “Dual-Kinetics Ratkowsky” model (Ratkowsky DK), which simultaneously describes temperature dependences of microbial growth and
Background: Monitoring of healthcare quality is typically focused on differences between group averages in relation to a desirable benchmark. However, we need to consider (i) the existence of interconnected socioeconomic axes of inequality like age, sex, income, and country of birth and (ii) individual heterogeneity around group averages. Additionally, (iii) we need clear criteria to quantify grou
Current scholarship on urban transformation emphasizes the importance of learning, but the state of the art of research on learning dynamics in urban transformations is still conceptually and empirically fragmented. To address this deficit, we propose a research agenda and related conceptual apparatus that draws upon previous research in urban transformations and cognate fields. The proposed agend
A text by Gertrud Sandqvist as a response to the work Morning Haze by Oscar Eriksson, exhibited at Galleri Arnstedt in Båstad
The project offers a study of German-Jewish thought by examining Walter Benjamin’s notion of law through the interpretive framework of the Talmud. The widely recognised locus of Benjamin's discussion of law is his essay Toward the Critique of Violence. In his later essays on Kafka, however, Benjamin develops an alternative to the familiar negative notion of law found in the Critique, a development
