Ribonucleotide reductase (RNR) is a central enzyme for DNA building block synthesis. Most aerobic organisms, including nearly all eukaryotes, have class I RNRs consisting of R1 and R2 subunits. The catalytic R1 subunit contains an overall activity site that can allosterically turn the enzyme on or off by the binding of ATP or dATP, respectively. The mechanism behind the ability to turn the enzyme

This paper studies the Swedish experience of the international crisis of 1907, which is often compared with the crisis of 2008. By constructing a new dataset from previously unanalyzed monthly bank-level data, we document high-frequency changes in bank outcomes throughout the 1907 crisis. While distressed banks suffered substantial withdrawals of foreign funds and liquid domestic liabilities, we s

Automated consistent software updating is challenging for distributed internet-of-things applications. We are developing a solution based on allowing several versions of the software to coexist on the same device, so that new and old software can be gradually phased in and out. We demonstrate our solution using a smart-city application for preventing thefts of bike batteries.

Human dependence is a phenomenon with above all negative connotations. We tend to associate it either with addiction or an economic, social and emotional lack of independence and view it as an impediment to women’s liberation. Dependence has been viewed as mutually exclusive to freedom. This is particularly the case in a country like Sweden, where independence is built in to the societal system so

Educational and income gradients in health are well established in the literature but there is need for a better understanding of how mental health inequalities change over time, and what drives the development. We aim to study how psychiatric diagnosis and its income-related inequality have changed over time in Sweden and to make a first attempt at disentangling the development by decomposing any

Photonic materials for high-temperature applications need to withstand temperatures usually higher than 1000 °C, whilst keeping their function. When exposed to high temperatures, such nanostructured materials are prone to detrimental morphological changes, however the structure evolution pathway of photonic materials and its correlation with the loss of material's function is not yet fully underst

Mortality differentials by socioeconomic status (SES) are among the most pervasive facts of contemporary demography. However, while the mortality gradient by income, class and education is well-established for the period after 1970, evidence regarding the origins of the gradient is still scarce. The aim of this thesis is to explore the development of SES differences in all-cause and cause-specific

Introduction: It remains unclear whether offering psychiatric patients their preferred treatment influences outcomes at the symptom level. Objective: To assess whether offering patients with Panic Disorder with/without Agoraphobia (PD/A) a choice between two psychotherapies yields superior outcomes to random assignment. Methods: In a doubly randomised, controlled preference trial (DRCPT), 221 adul

This paper presents an investigation on the compressive behavior of plain concrete columns confined with steel-reinforced grout (SRG) composites. The test parameters include size and crosssectional shape (square or circular) of the columns, and number of layers (one or two) and density (low or medium density) of the steel fiber sheet. Out of 46 specimens herein presented, 33 were confined with SRG

Academic training is the initial step for junior scientists to learn to develop into independent scientists. This study investigates how supervisors decide to employ different approaches of early-career research training, and how these approaches influence the degree of trainees’ independence in their later careers. Drawing on survey and bibliometric data of life scientists in Japanese universitie

The Upper Paraná River Basin (UPRB) has undergone extensive Land Use and Cover Changes (LUCC) in thelatest decades, due to rapid population growth and economic development. Furthermore, variation in precipitationpatterns was observed across the basin mainly after the 1970s Climate shift. Concurrently, the UPRB has presentedsignificant changes in its hydrology. In this context, this thesis investig

A technique for enhancing the bandwidth of a broadside tri-modal patch antenna is described. The key idea of the technique is to incorporate a dual-resonance structure into the broadside tri-modal patch geometry. By increasing one edge of the tri-modal patch while decreasing its size at the opposite edge, the resulting structure can be viewed as two super-imposed Y-shaped structures of different r