BackgroundCancer-associated fibroblasts (CAFs) comprise a heterogeneous population of stromal cells within the tumour microenvironment. CAFs exhibit both tumour-promoting and tumour-suppressing functions, making them exciting targets for improving cancer treatments. Careful isolation, identification, and characterisation of CAF heterogeneity is thus necessary for ex vivo validation and future impl

When semiotics of architectural space turns from an interest in the visual revelation of a space “hidden” behind city plans or types of building facades, and focuses more on the socio-logical or narrato-logical interaction between humans, rules and matter, the subject of investigation (i.e. space) consequently turns more corporeal, more situation-based, and more political. In his philosophy of spa

Two key challenges for governing and managing critical infrastructure risk and resilience are interdependencies between infrastructures and the multi-actor setting in which they operate. This paper looks beyond the Critical Infrastructure (CI) field of research to identify and discuss cross-disciplinary approaches to address these challenges. It explores two related and slightly overlapping resear

AbstractDe senaste årtiondena så har shoppingens geografiska manifestationer förändrats i grunden. Den förmodade ”döden” som har förutspåtts för shopping i stadskärnor har blivit alltmer angeläget. Vetenskapliga studier har undersökt de sociala, kulturella och ekonomiska orsakerna till shoppingens decentralisering och dess effekter på stadslivet. Få studier har dock hittills fokuserat på den föränDuring recent decades, shopping’s geographical manifestations have altered radically and the presumed ‘death’ of town centre retailing has become a public concern. The social, cultural, and economic backgrounds of this decentralisation of retail and its effects on city life have been studied comprehensively. However, to date, few studies have examined the changing dynamics of non-mainstream shoppi

The Volgo-Uralia segment, which constitutes one fourth of the East European Craton, is covered by sedimentary deposits. From geophysical studies and examination of thousands of drillcores, Volgo-Uralia has been recognised as a vast high-grade terrain with a complex crustal history extending from the Palaeoarchaean to the Palaeoproterozoic. Our recent studies are focused on the search for the oldes

New digital food platforms are being launched accompanied with the promise of also promoting more sustainable food consumption. However, despite some success, many of these efforts to digitally reconfigure consumers food practices fail. The aim of this paper is to empirically explore, conceptualize and explain such failures. Taking a practice theory approach, and drawing on a field experiment usin

The sharing economy is a novel way of distributing physical resources facilitated by online platforms where temporary access is given to goods owned by peers or organisations. It has become prominent in urban areas where a large accumulation of resources in close proximity and the ubiquity of information and communications technology enable it to grow. Its emergence has had various impacts on exis

The response of soil microbial activity to climate warming has been predicted to have a large destabilising effect on the carbon cycle. However, the nature of this feedback remains poorly understood, especially in tropical ecosystems and across annual to decadal timescales. We studied the response of bacterial community growth to 2 and 11 years of altered temperature regimes, by translocating soil

Both the East Asian winter monsoon (EAWM) and El Niño (EN) activities are vital climate modes that regulate the Pacific hydrologic cycle. However, the Holocene interactions among the EAWM, EN activities, and tropical Pacific precipitation remain unclear due to the lack of appropriate EAWM proxies. Here, we present high-resolution grain size records from the East China Sea shelf along with a transi

Bis(phosphinidene)-capped triiron carbonyl clusters, including electron rich derivatives formed by substitution with chelating diphosphines, have been prepared and examined as proton reduction catalysts. Treatment of the known cluster [Fe3(CO)9(µ3-PPh)2] (1) with various diphosphines in refluxing THF (for 5, refluxing toluene) afforded the new clusters [Fe3(CO)7(µ3-PPh)2(κ2-dppb)] (2), [Fe3(CO)7(µ

Large-scale radiation emergency scenarios involving protracted low dose rate radiation exposure (e.g. a hidden radioactive source in a train) necessitate the development of high throughput methods for providing rapid individual dose estimates. During the RENEB (Running the European Network of Biodosimetry) 2019 exercise, four EDTA-blood samples were exposed to an Iridium-192 source (1.36 TBq, Tech

This document is a position statement from the Society for Cardiovascular Magnetic Resonance (SCMR) on recommendations for clinical utilization of cardiovascular magnetic resonance (CMR) in women with cardiovascular disease. The document was prepared by the SCMR Consensus Group on CMR Imaging for Female Patients with Cardiovascular Disease and endorsed by the SCMR Publications Committee and SCMR E

Thin, stable and inert dielectric spacers are essential for manufacturing electronic devices based on 2D materials. However, direct synthesis on top of 2D materials is difficult due to their inert nature. In this work, we studied how an electron beam induces fragmentation of borazine and enables spatially confined synthesis of amorphous-BNx on graphene at room temperature. Using a combination of X

Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors th