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Aims. We report the discovery of a massive and dense transiting planet CoRoT-27b on a 3.58-day orbit around a 4.2 Gyr-old G2 star. The planet candidate was identified from the CoRoT photometry, and was confirmed as a planet with ground-based spectroscopy. Methods. The confirmation of the planet candidate is based on radial velocity observations combined with imaging to rule out blends. The charact

AimEndometriosis is one of the most common gynecologic diseases in women of reproductive age. The pathophysiology of endometriosis is still not fully understood. Phoenixin (PNX-14) is a newly discovered neuropeptide that regulates the hypothalamo–pituitary–gonadal (HPG) axis and reproductive functions. Recently, we reported that PNX-14, its precursor protein and receptor were expressed in human en

Recent developments in neuroscience and artificial intelligence have allowed machines to decode mental processes with growing accuracy. Neuroethicists have speculated that perfecting these technologies may result in reactions ranging from an invasion of privacy to an increase in self-understanding. Yet, evaluating these predictions is difficult given that people are poor at forecasting their react

Lunds Botaniska Förening och Eslövs kommun har genomfört ett LONA-projekt 2020–2022 inom vilket kommunens ansvarsarter humlesuga, Betonica offi- cinalis L., och kärrnäva, Geranium palustre L., har odlats och planterats på reservlokaler. Även ängs- skära, Serratula tinctoria L., och gullstånds, Jaco- baea paludosa (L.) P. Gaertn., har ingått i projektet. Antalet spontana exemplar i kommunen uppgickA LONA (local nature conservation support) project administrated by Eslöv town in cooperation with Lund Botanical Society was undertaken in 2020– 2022 to determine the status of the protected plant species Betony (Betonica officinalis L.) and Marsh Crane’s-bill (Geranium palustre L.) in natural popu- lations. The second main goal of the project was to establish the species in planted back-up local

Stagnelius och Rydstedts dikter delar en starkt dualistisk syn på tillvaron. Den kan i båda fallen knytas till Johannesevangeliets också starkt dualistiska värld. Rydstedt använder i sina dikter både Stagnelius och Johannesevangeliet; här utreds hennes bruk av stagnelianska formuleringar. I alla tre fallen övervinns den starka dualismen på delvis olika sätt.

Bone morphogenetic proteins (BMP) are powerful regulators of cellular processes such as proliferation, differentiation, and apoptosis. However, the specific molecular requirements controlling the bioavailability of BMPs in the extracellular matrix (ECM) are not yet fully understood. Our previous work showed that BMPs are targeted to the ECM as growth factor-prodomain (GF-PD) complexes (CPLXs) via

To stay within planetary boundaries, we need to move into sustainable levels of resource consumption, or sufficiency. Businesses can play a key role in driving sufficiency as they satisfy and also create demand. This article investigates how a bicycle subscription company can promote sufficiency among its users, with a focus on modal shift and product care. It aims to fill the research gap on how

Background: Failed management of unanticipated difficult airway situations contributes to significant anesthesia-related morbidity and mortality. Optimization of design and layout of difficult airway trolleys (DATs) may influence outcomes during airway emergencies. The main objective of the current study was to evaluate whether a difficult airway algorithm-based DAT with integrated cognitive aids

We report on the development of a method based on recombinant yeast Saccharomyces cerevisiae to produce nonivamide, a capsaicinoid and potent agonist of the pain receptor TRPV1. Nonivamide was produced in a two-step batch process where yeast was i) grown aerobically on glucose and ii) used to produce nonivamide from vanillin and non-anoic acid by bioconversion. The yeast was engineered to express

In transplants of embryonic striatal cells placed into the excitotoxically lesioned rat striatum (a model of Huntington's disease), as many as 60 to 90% of the grafted cells are believed to die. Caspase activation is part of a cascade of events that can lead to apoptosis. We investigated the effect of the caspase inhibitor acetyl-tyrosinyl-valyl-alanyl-aspartyl-chloromethylketone (Ac-YVAD-cmk) on In transplants of embryonic striatal cells placed into the excitotoxically lesioned rat striatum (a model of Huntington's disease), as many as 60 to 90% of the grafted cells are believed to die. Caspase activation is part of a cascade of events that can lead to apoptosis. We investigated the effect of the caspase inhibitor acetyl-tyrosinyl-valyl-alanyl-aspartyl-chloromethylketone (Ac-YVAD-cmk) on

As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understud

A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons.

This chapter exemplifies rodent models of Parkinson's disease that have been used in transplantation studies and recounts basic transplantation methods. It describes morphological features of grafts containing dopamine neurons and focuses on the role of nigral grafts that are implanted homotopically in the mesencephalon, for example, near their location in the normal brain. The neurotoxin 6-hydrox

Utredningens uppdrag är att undersöka vilka åtgärder som behövervidtas för att skapa en långsiktig och hållbar rättslig reglering för utlämnande av försäljningsstatistik som avser läkemedel för människor.Behovet av en mer ändamålsenlig reglering har aktualiserats som enföljd av att E-hälsomyndigheten och Socialstyrelsen efter rättsligaställningstaganden, med hänsyn till bestämmelsen om statistikse

Over the last decades, there has been a rapid increase of the number of climate change initiatives outside the UNFCCC. In research this is referred to as ‘institutional fragmentation’, and it encompasses a wide range of public, private and hybrid initiatives, at various levels of governance. This development is extensively discussed in the IPCC Fifth Assessment Report AR5. Chapters 13-16 of the Wo

Översiktlig artikel om hur spanska sjukan 1918 drabbade Lunds universitet och särskilt dess studenter samt om hur vissa professorer i medicin förhöll sig till den nya smittan.