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Aeolian dynamics at the northern edge of Deliblato (Banat) Sand Sea, Vojvodina, Serbia, at the time of the last deglaciation

The Deliblato (Banat) Sand Sea, which is one of the largest areas of aeolian sand in Europe, is located near the Iron Gate, which marks the crossing of the Danube River through the biggest gorge of this river. Here, Danubian alluvium has served as the sand source for the Banat Sand Sea, which was formed primarily through southeasterly (Košava) winds. Utilizing a multi-proxy approach, the objective

Exploring predictive kinetic modelling of thermal degradation from laboratory to production scale – A case study on three vitamins in milk

Kinetic thermal degradation models are vital components for optimization of food and bioproducts processing. Typically, models are fitted to laboratory-scale experiments where vials are heated and held. However, these conditions are highly dissimilar from the thermal processes experienced in industrial production. Whereas fitting kinetic data to industrial-scale production is often impossible due

Experiences of managers and staff working in community-based mental health with people ageing with severe mental health problems

Background: Existing research shows that older people with severe mental health problems need different forms of support in daily life and in the community to lead an active and meaningful life. A common form of support for people with severe mental health problems in Sweden is attendance at community-based day centres (DCs). However, knowledge of staff and managers’ experiences of how people agei

Comparison of aluminum nitride thin films prepared by magnetron sputter epitaxy in nitrogen and ammonia atmosphere

Wurtzite-type aluminum nitride (AlN) thin films exhibiting high thermal conductivity, large grain size, and low surface roughness are desired for both bulk acoustic wave and surface acoustic wave resonators. In this work, we use ammonia (NH3) assisted reactive sputter deposition of AlN to significantly improve these properties. The study shows a systematic change in the structural, thermal, and mo

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myocardial infarction and heart failure, the influence of CHIP in cardiac arrhythmias, such as atrial fibrillation (AF), is less explored. METHODS: CHIP prev

X-ray standing-wave spectroscopy : A powerful method for probing buried interfaces

In this chapter we present a non-destructive method for characterizing buried interfaces with high depth resolution combining X-rays standing wave and photoemission electron spectroscopy. This method incorporates the power of the X-rays photoelectron spectroscopy, which is a surface sensitive technique in the nanometer and sub-nanometer regime, with the depth selectivity of X-ray standing wave. Th

Endosomal escape of RNA therapeutics

RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key challenges with the development of new RNA-based t

Photon-counting computed tomography for paediatric congenital heart defects yields images of high diagnostic quality with low radiation doses at both 70 kV and 90 kV

Background: Photon-counting computed tomography (PCCT) is a new clinical method that may show better diagnostic quality at lower radiation doses than conventional CT. Objective: To investigate the diagnostic quality and radiation dose of paediatric cardiovascular PCCT for diagnosis of congenital heart defects at 70 kV and 90 kV. Materials and methods: This retrospective assessment included clinica

Reconciling East Asia's mid-Holocene temperature discrepancy through vegetation-climate feedback

The term “Holocene temperature conundrum” refers to the inconsistencies between proxy-based reconstructions and transient model simulations, and it challenges our understanding of global temperature evolution during the Holocene. Climate reconstructions indicate a cooling trend following the Holocene Thermal Maximum, while model simulations indicate a consistent warming trend due to ice-sheet retr

Machining SiC fibre reinforced metal matrix composites – How do different matrix materials affect the cutting performance?

SiC fibre reinforced metal matrix composites find widespread application but show major machining difficulties due to significant variations in constituents' properties. In this sense, while the SiC fibre plays significant strengthening effects, the properties mismatch between the brittle fibre and ductile matrix materials becomes important in their machining performance. Through machining tests,

Home capillary sampling and screening for type 1 diabetes, celiac disease, and autoimmune thyroid disease in a Swedish general pediatric population : the TRIAD study

Objective: To screen a general pediatric population for type 1 diabetes (T1D), celiac disease (CD), and autoimmune thyroid disease (AITD) after home capillary sampling. Methods: Swedish schoolchildren between 6–9 years and 13–16 years of age were invited to screening by taking a capillary sample at home. Samples were returned by mail and assessed for autoantibodies associated with T1D, CD, and AIT

Flux and symmetry effects on quantum tunneling

Motivated by the analysis of the tunneling effect for the magnetic Laplacian, we introduce an abstract framework for the spectral reduction of a self-adjoint operator to a hermitian matrix. We illustrate this framework by three applications, firstly the electro-magnetic Laplacian with constant magnetic field and three equidistant potential wells, secondly a pure constant magnetic field and Neumann

Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion

The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent mechanisms of resistance to PTC-acting drugs is C8-methylation of the universally

Osmanska riket

Boken är en syntes av Osmanska rikets historia från 1200-talet till 1900-talet.

Den finska arbetsmarknadsmodellen under press

Den nya högerledda regeringen i Finland under Petteri Orpo är i full färd med att göra genomgripande förändringar av den finska arbetsmarknadsmodellen. Det handlar om konflikträtten, lönebildningen, förhandlingssystemet och de sociala förmånerna:•Begränsad rätt till sympatiåtgärder och politiska strejker samt kraftigt ökade böter i samband med olagliga konfliktåtgärder•Statliga medlare får inte go

The Lasso and Ridge Regression Yield Biased Estimates of Imbalanced Binary Features

Many regularized methods, such as the lasso and ridge regression, are sensitive to the scales of the features in the data. As a consequence, it has become standard practice to normalize(center and scale) features such that they share the same scale. For continuous data, the most common strategy is standardization: centering and scaling each feature by its mean andand standard deviation, respective

Kampanjen mot atomvapen och det tidiga 1960-talets svenska protestrepertoar

1961 grundades en ny social rörelse i Sverige. Den fick namnet Kampanjen mot atomvapen (KMA) och var en svensk gren av en internationell, gränsöverskridande rörelse som startat året innan med bas i Västeuropa. Målet med rörelsen var att få supermakterna att avrusta sina kärnvapenrörelser och, för svensk del, att få Sverige att upphöra med sitt pågående kärnvapenprogram. I Sverige spelade KMA en viA new social movement was formed in Sweden in 1961: Kampanjen mot atomvapen (KMA, “The Campaign for Nuclear Disarmament”). Opposing the military’s plans to acquire Swedish nuclear bombs and protesting against the escalating tensions of the Cold War, KMA in the years 1961‒1963 rallied young people and students and introduced several new forms of collective political actions in the Swedish repertoir