This article proposes a critical legal analysis of the jurisprudence of the Inter-American Court of Human Rights regarding indigenous peoples’ rights to lands, participation, and consultation. It focuses on the role that cultural diversity as a legal standard has played in the recognition of the indigenous peoples’ right to consultation and participation in all matters that directly affect them, a

In a series of famous experiments, Benjamin Libet claimed to have shown that there is no scientific basis for our commonsensical understanding of freedom of the will. The actions we are about to undertake register in our brains before they register in our conscious minds. And yet, all that Libet may have shown is that long-invoked notions such as “the will” and “freedom” are poor explanations of h

Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increa

The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the mese

This paper explores the meaning and potential impact of a number of street artworks that in different ways address and problematise how human beings relate to the biotic community – that is to say a community founded on biocentrism that includes as its members “soils, waters, plants, and animals, or collectively: the land” (Leopold, 1949/1968, p. 203.).The paper argues that while, for example, inf

INTRODUCTION: Not only repolarization, but also depolarization ECG indexes reflect the progression of ischemic injury. The aim was to assess the QRS duration and morphology dynamics during the prolonged coronary occlusion and their association with the myocardial area at risk (MaR) and final infarct size (IS).METHODS: In pigs, myocardial infarction was induced by inflation of an angioplasty balloo

Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. The YAC128 mouse model of HD expresses the full-length human huntingtin protein with 128 CAG repeats and replicates the phenotype and neurodegeneration that occur in HD. Several studies have implicated a role for neuroinflammation in HD pathogenesis. Studies on presymp

The purpose of this work is to develop and implement a simple and robust preservation technology that can enhance food and economic security and thereby improve the lives of people in developing countries. The technique under development is termed “solar assisted pervaporation (SAP)”. It is a sustainable technology whereby fruit juices or purées are concentrated using reusable pouches made of “bre

Den 15 mars hoppade Felix Baumgartner från 22 km höjd. Detta var ett steg på vägen att slå det tidigare höjdrekordet: Joe Kittinger hoppade 1960 hoppade från en heliumballong på mer än 3 mils höjd, som en del av USAs rymdprogam. Att man kan komma så högt med en heliumballong, och sedan falla mot jorden, medan temperaturen varierar och luftens densitet och luftmotståndet hela tiden ökar, inbjuder t

Hopp från ballonger på flera mils höjd inbjuder till fysiksamtal.

Due to the increasing power requirement and the limited available space in vehicles, placing the heat exchanger at the roof or the underbody of vehicles might increase the possibility to handle the cooling requirement. A new configuration of the heat exchanger has to be developed to accommodate with the position change. In this paper, a countercurrent heat exchanger is developed for position on th

The manifesto of a new philosophy of technology

Many studies assume a respiratory quotient (RQ = molar ratio of CO2 produced to O2 consumed) close to 1 when calculating bacterioplankton respiration. However, evidence suggests that RQ depends on the chemical composition of the respired substrate pool that may be altered by photo-chemical production of oxygen-rich substrates, resulting in elevated RQs. Here we conducted a novel study of the impac

Specialiseringstjänstgöringen i Sverige har under de senaste åren genomgått genomgripande förändringar och ställer handledare av ST-läkare inför nya förutsättningar och utmaningar. Denna bok är skriven för handledare av läkare under utbildning och för alla som är intresserade av sådan handledning. Författarna utgår från de nya föreskrifterna och målbeskrivningarna och visar hur handledningen kan

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods: Literature se

Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact. In this study, we identified CNTN5 and CNTN6 deleteriousvariants in individuals