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Background and purpose: The study aims to evaluate dosimetric properties of hypofractionated treatment plans integrating focal boost, using registered whole-mount histopathology (WMHP) as reference standard. Methods: Fifteen men from the PAMP trial (EudraCT: 2015-005046-55) were included. Participants had ≥ 1 ISUP Grade group ≥ 4 lesion and underwent [68Ga]prostate-specific membrane antigen (PSMA)

Extended Reality (XR) serves as a broad term that encompasses several immersive technologies, including Augmented Reality (AR), Mixed Reality (MR), and Virtual Reality (VR). Currently, most XR devices are connected by cables, which restrict user mobility and negatively impact the overall Quality of Experience (QoE) for users. XR devices face limitations not only in terms of connectivity but also i

Nestling feeding in altricial birds is a physiologically demanding phase of the annual cycle. Accordingly, parental effort in breeding songbirds has been suggested to be limited by the maximum capacity to perform sustained aerobic work. However, the maximum capacity for exercise and plasticity thereof is understudied in free-living, breeding songbirds. We tested two predictions related to the plas

Background Nurses constitute a central profession in the cardiac rehabilitation (CR) team delivering comprehensive CR to individuals with cardiovascular disease. We aimed to identify specific components reflecting the nurses' role in the CR team associated with attainment of risk factor targets post myocardial infarction. Methods Center-level data (n = 78) was used from the Perfect-CR study, in wh

Background: It is unclear whether the two device-aided therapies (DATs: deep brain stimulation [DBS] and levodopa–carbidopa intestinal gel [LCIG]) affect personality in patients with Parkinson’s disease (PD). Objective: This retrospective study aims to explore if patients with PD and their close relatives experience any changes in the patient’s personality following the start of DAT. Methods: In t

This chapter describes the core concept sense of coherence (SOC), in terms of definition, measurement, distribution, dimensionality and stability over time. The extensive evidence base of research after Antonovsky died, shows that SOC is a multidimensional and culturally sensitive life orientation. To date, the SOC questionnaire has been used in at least 73 countries all over the world. In additio

Additive manufacturing (AM), particularly Laser Powder Bed Fusion, produces surfaces with unique, randomly distributed spherical roughness that significantly influences heat transfer and pressure loss. This study models AM roughness using a statistical distribution of spheres and performs high-fidelity simulations at a bulk Reynolds number of 12,000 to evaluate heat transfer on a rough pipe. Stati

Research on adolescent sexual orientation has expanded in recent decades, yet little is known about its associations with personality traits during this developmental period. This study examined personality dimensions, as measured by the Junior Temperament and Character Inventory, across adolescent sexual orientation groups (asexual, homosexual, heterosexual, bisexual) in a community-based sample

Background and aims: The aim of the present study is to examine the association between parenting practices and adolescent alcohol use in a longitudinal sample of adolescents from Sweden. Data and methods: A prospective longitudinal sample of 3,685 adolescents in a nationwide study in Sweden (2017-2019) filled out questionnaires. Baseline data (T1; 2017) was collected from participants at age 15 t

INTRODUCTION: Blood-based biomarkers have demonstrated high accuracy for identifying Alzheimer's disease (AD) pathology. However, the lack of representative cohorts creates a knowledge gap regarding their real-world applicability. We examined the influence of ethnicity on the diagnostic accuracy of plasma tau phosphorylated at threonine 217 (p-tau217) in identifying AD. METHODS: A total of 1170 mi

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective

Context. Studies of the internal kinematics of the LMC have provided a detailed view of its structure, largely thanks to the exquisite proper motion data supplied by the Gaia mission. However, line-of-sight (LoS) velocities, the third component of the stellar motion, are only available for a small subset of the current Gaia data, thus limiting studies of the kinematics perpendicular to the LMC dis

ImportanceThe genetic variation in patients with sensorineural hearing loss (SNHL) in the Nordic countries has not been previously reported.ObjectivesThe aim was to describe the genetic variation in a Swedish population and identify factors in favor of a high diagnostic yield.DesignThis was a prospective cohort study. Children with bilateral SNHL and adults with bilateral SNHL and clinically suspe

Purpose: To investigate the rates of knee reoperation and medical complications after meniscal repair versus partial meniscectomy (APM) up to 10 years after surgery. Methods: All patients ≥ 15 years old operated for a meniscal tear with meniscus repair or partial meniscectomy at Scania University Hospital were included, between year 2010 and 2014. Information was retrieved from patient records unt

Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionall

Motivation Efforts to address health disparities are often limited by the lack of robust computational tools for inferring genetic ancestry by calculating an individual's genetic similarity to continental groups. We have already shown that a preferred alternative to self-described race is using ancestry-informative markers (AIMs) that can be classified into ancestral components and used to estimat

Magnetic resonance imaging (MRI) enables non-invasive monitoring of healthy brain development and disease. Widely used higher field (>1.5 T) MRI systems are associated with high energy and infrastructure requirements, and high costs. Recent ultra-low-field (<0.1 T) systems provide a more accessible and cost-effective alternative. However, it remains uncertain whether anatomical ultra-low-field neu

This study examines the effectiveness of LU-PZE, a web-based interactive tool designed to help students visualize and interact with fundamental concepts in automatic control. A total of 200 students enrolled in an introductory course on automatic control had the option to use LU-PZE as an additional resource for learning. LU-PZE offers users randomized quizzes, structured assignments, and real-tim