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Alpha-synuclein (α-Syn) can misfold and aggregate, causing the degeneration of dopaminergic neurons, as seen in Parkinson's disease (PD). We recently demonstrated that DNAJB6, a co-chaperone found in Lewy bodies (LB), suppresses the aggregation of α-Syn in cells and in vitro. In this study, we compared the capacities of DNAJB1 and DNAJB6 to suppress the seeded α-Syn aggregation in HEK293 cells exp

BACKGROUND Diarrhea is a major infectious cause of childhood morbidity and mortality worldwide. In clinical trials, Lactobacillus rhamnosus GG ATCC 53013 (LGG) has been used to treat diarrhea. However, recent randomized controlled trials (RCTs) found no evidence of a beneficial effect of LGG treatment. AIM To evaluate the efficacy of LGG in treating acute diarrhea in children. METHODS The EMBASE,

Crop residue addition is a way to increase soil organic matter (SOM) level in croplands. However, organic matter input and SOM stocks are not linearly related. Consequently, adding high amounts of residues, such as straw, may increase SOM to only a small extent, and an alternative use of the residues may be justified. The objective of this study was to test how the level and type (above- or belowg

Bioslurry obtained from biogas plants has the potential to reduce the use of expensive chemical fertilizers and increase yields. A field experiment was conducted to investigate the growth response and yield production of okra fertilized with various combinations of bioslurry and nitrogen fertilizer. The experiment was planned according to randomized complete block design with 3 replications. Biosl

Deficiency of micronutrients, particularly of zinc, boron, and iron, in calcareous soils is of great concern. Results indicate a reduction in yield of seed-cotton due to an imbalance of nutrients, particularly micronutrients, on calcareous soils in the last decade. About 90% of Pakistani soils are deficient in micronutrients, particularly zinc, boron, and iron. This paper highlights efforts to ove

Incubation experiments are the most common approach to measure methane (CH 4 ) oxidation potential in soils from various ecosystems and land-use practices. However, the commonly used headspace CH 4 injection into microcosms and the shaking of the soil slurry during incubation fully removes CH 4 (soil-born) and O 2 (air-born) gradients common in situ, and may also induce various errors and disturb

Exotic ordered ground states driven by electronic correlations are expected to be induced in monolayer graphene when doped to the Van Hove singularity. Such doping levels are reached by intercalating Gd in graphene on SiC(0001), resulting in a strong homogeneity and stability. The electronic spectrum now exhibits severe renormalizations. Flat bands develop which are driven by electronic correlatio

The aim of this article is to explore how the Chernobyl catastrophe in 1986 has been represented in seven feature films from the three countries mostly affected by the nuclear disaster: Ukraine, Belarus and Russia. The narratological analysis indicates that the films from all of these three countries represent Chernobyl as an apocalyptic event making personal rebirth possible. Although the context

To overcome soil nutrient limitation, many plants have developed complex nutrient acquisition strategies including altering root morphology, root hair formation or colonization by arbuscular mycorrhizal fungi (AMF). The interactions of these strategies and their plasticity are, however, affected by soil nutrient status throughout plant growth. Such plasticity is decisive for plant phosphorus (P) a

BACKGROUND: Follow-up with computed tomographic angiography is recommended after endovascular aneurysm repair, exposing patients to significant levels of radiation and iodine contrast medium. Dual-energy computed tomography allows virtual noncontrast (VNC) images to be reconstructed from contrast-enhanced images using a software algorithm. If the VNC images are a good-enough approximation of true

Recent work applying multidimentional coherent electronic spectroscopy at dilute samples in the gas phase is reviewed. The development of refined phase cycling approaches with improved sensitivity has opened up new opportunities to probe even dilute gas-phase samples. In this context, first results of two-dimensional spectroscopy performed at doped helium droplets reveal the femtosecond dynamics u

This report presents the outcome of the joint work of PhD students and senior researchers working with DNA-based biodiversity assessment approaches with the goal to facilitate others the access to definitions and explanations about novel DNA-based methods. The work was performed during a PhD course (SLU PNS0169) at the Swedish University of Agricultural Sciences (SLU) in Uppsala, Sweden. The cours

Data defined software is becoming more and more prevalent, especially with the advent of machine learning and artificial intelligence. With data defined systems come both challenges - to continue to collect and maintain quality data - and opportunities - open innovation by sharing with others. We propose Open Data Collaboration (ODC) to describe pecuniary and non-pecuniary sharing of open data, si

The ubiquitous digitization of information and the pervasive connectivity of work systems have inevitably facilitated cyber-enabled industrial espionage. Security failures explain most of cyber industrial espionage incidents, and insider threats represent a significant pattern in many case examples. Insiders can inadvertently or purposefully pose serious threats to organisations by facilitating ac

Algorithms for Massive MIMO uplink detection are typically based on a centralized approach, by which baseband data from all antenna modules need to be routed to a central node for further processing. In the case of Massive MIMO, where hundreds or thousands of antennas are expected in the base-station, such architecture requires high interconnection bandwidth between antennas and the central node.