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Vertebrate leukotriene A(4) hydrolases are bifunctional zinc metalloenzymes with an epoxide hydrolase and an aminopeptidase activity. In contrast, highly homologous enzymes from lower organisms only have the aminopeptidase activity. From sequence comparisons, it is not clear why this difference occurs. In order to obtain more information on the evolutionary relationship between these enzymes and t

Background: Voltage-dependent K+ channels (Kv) mediate repolarisation of beta-cell action potentials, and thereby abrogate insulin secretion. The role of the Kv1.1 K+ channel in this process is however unclear. We tested for presence of Kv1.1 in different species and tested for a functional role of Kv1.1 by assessing pancreatic islet function in BALB/cByJ (wild-type) and megencephaly (mceph/mceph)

Poly(arylene ether sulfone)s carrying various aromatic mono-, di-, and trisulfonated side´chains have been investigated with respect to their nanoscale structure and key membrane properties. Sulfobenzoyl, sulfonaphthoxybenzoyl, disulfonaphthoxybenzoyl, and trisulfopyrenoxybenzoyl side chains were attached to the poly(arylene ether sulfone) main chain by employing different combinations of metallat

Several ecologically and commercially important fish species spend the winter in a state of minimum feeding activity and at lower risk of predation. To enable this overwintering behaviour, energetic reserves are generated prior to winter to support winter metabolism. Maintenance metabolism in fish scales with body size and increases with temperature, and the two factors together determine a critic

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF). Although patients with CF often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that CFTR has a biological function in pancreatic beta-cells.

Osteoporosis and low bone strength in older people may be due to low bone mass accrual or elevated age-related loss of bone mass. The mechanisms underlying loss of bone mass have long been subjected to research. However, research has only started in the last decade to focus on strategies to increase bone mass:the current opinion is that childhood and adolescence are critical periods for building u

To study and compare the safety of intersection, traffic scientists today typically manually monitor the intersection during several days and count how often certain events such as evasive manoeuvres occur. This is a laboursome and costly procedure. The aim of this thesis is to provide tools that can reduce the amount of manual labour required by using automated video analytics. Two methods for cr

As new systems and applications are introduced for next-generation wireless systems, the propagation channels in which they operate need to be characterized. This paper discusses propagation channels for four types of next-generation systems: (i) distributed Multiple-Input Multiple-Output (MIMO) and Cooperative MultiPoint (CoMP), systems, which require the characterization of correlation between c

The ambition in this thesis is to try out an alternative language for music didaktik relations during music activity in preschool settings. The aim of the study is to describe and to analyze the didaktiks in music activity in preschool settings. The aim of the study is also on research basis to try out concepts that denote and capture the figuration of music activity. The overall research question

Evolution and ecological diversification in a heterogeneous environment is driven by an often complex interplay between local adaptation and dispersal between different habitat types. Heterogeneous environments also easily generate source-sink dynamics of populations coupled by dispersal. It follows that local adaptation and possible adaptive radiation almost by necessity involves adaptation to a

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Mer än 7000 kvinnor insjuknar varje år i bröstcancer, och cirka 1500 dör i sjukdomen. Incidensen av bröstcancer har stigit kontinuerligt sedan 1970-talet, och man uppskattar att en av tio kvinnor i Sverige kommer att utveckla bröstcancer någon gång under sin livstid. Den relativa överlevnaden i sjukdomeCancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to

Recension av Ben Kiernan; Blod och jord. Historien om folkmord och utrotning, från Sparta till Darfur.

Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of lepti

A search for microscopic black holes has been performed in a same-sign dimuon final state using 1.3 fb(-1) of proton-proton collision data collected with the ATLAS detector at a centre of mass energy of 7 TeV at the CERN Large Hadron Collider. The data are found to be consistent with the expectation from the Standard Model and the results are used to derive exclusion contours in the context of a l

Service discovery is central in pervasive middleware systems, built on top of the communication substrate using the more fundamental mechanisms for device discovery. In mobile pervasive systems devices come and go, and switch network frequently, demanding support for device discovery across heterogeneous networks. We present the design of a device discovery mechanism for the PalCom middleware that

Abstract in UndeterminedThe recent MPEG Reconfigurable Media Coding (RMC) standard aims at defining media processing specifications (e.g. video codecs) in a form that abstracts from the implementation platform, but at the same time is an appropriate starting point for implementation on specific targets. To this end, the RMC framework has standardized both an asynchronous dataflow model of computat

Loss of the tumor suppressor gene von Hippel–Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to stabilization of the HIF transcription complex, which induces angiogenic and mitogenic pathways essential for tumor formation. Nonetheless, additional oncogenic events have been postulated to be required for the formation of CCRCC tumors. Here,