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Aims T cells are present in atrial tissue from atrial fibrillation (AF) patients. However, prospective studies of T cells and AF development are few. The current aim was to investigate if T-cell subsets are associated with the risk of developing AF. Methods and results T-cell subsets, measured by flow cytometry of cryopreserved mononuclear leucocytes isolated from blood at baseline, were analysed
Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh
Despite recent progress within the field of immuno-oncology, immune suppression in the tumor microenvironment, defective antigen presentation, and low levels of tumor-specific T cells are key limitations of current cancer immunotherapies. CD40-targeting immunotherapies hold promises for addressing these limitations across solid tumors. Here, we describe ATOR-4066, a bispecific antibody that target
Response determinants to immunotherapy in metastatic pancreatic ductal adenocarcinoma (mPDAC) remain unclear, limiting treatment advancements. We report a single-arm phase 1b/2 study (OPTIMIZE-1) evaluating the safety and efficacy of the cluster of differentiation 40 (CD40) agonist mitazalimab combined with modified FOLFIRINOX (mFOLFIRINOX), in chemotherapy-naive patients with mPDAC. Patients rece
This chapter provides an overview of how claims for state redress have been articulated by memory activists and handled by representatives of the Nordic states from the 1990s to the 2020s. The main types of historical injustices under scrutiny in these processes of “politics of regret” are enslavement and overseas colonialism, abuse in care settings, and forced assimilation of the Sámi and nationa
This article examines how Swedish social democratic women used the enactment of universal suffrage in 1919/1921 as an argument to gain support for separate organising. The article also analyses the extent to which the Swedish National Federation of Social Democratic Women, founded in 1920, used direct (personal) and indirect (media) channels for voter communication. Both scarce economic resources
A search for the exclusive hadronic decays Formula Presented, Formula Presented, and Formula Presented is performed using up to Formula Presented of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of Formula Presented. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cro
Objectives: High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establ
According to recent lore, it is difficult to explain the evidence for a stochastic gravitational wave background obtained by pulsar timing arrays with supercooled first-order phase transitions (FOPTs). We demonstrate that supercooled FOPTs in dark U(1)′ models with a conformal dark sector easily explain the nHz signal at NANOGrav.
Objective: Previously proposed “synchronous EEG patterns” predict poor outcome within 24 h after cardiac arrest (CA). We investigate the prognostic performance of these early EEG predictors in addition to the late EEG predictors (>24 h) recommended in the European post-resuscitation guidelines. Methods: Observational substudy of the TTM2-trial including consecutive comatose resuscitated patients.
Boreal peatlands strongly affect the global climate system by providing an important store for carbon (C) cycle and a natural source of methane. Over the past century, however, vast areas of natural peatlands have been drained to gain productive land, turning them into large potential C sources. Currently, there is a scientific debate on how to best manage historically drained boreal peatlands to
The study aimed to investigate the unique lipid composition of Mycobacterium bovis BCG and its potential to enhance antimicrobial efficacy of lipid-coated mesoporous silica particles (MSPs). The bacterial lipids (BL) were extracted with petroleum ether and analyzed via LC-MS, revealing a complex mixture of phospholipids, including cardiolipin, phosphatidylcholine, phosphatidylethanolamine, and tri
Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical. Determining where to restore remains, however, a challenge. As an approach for prioritizing restoration areas, we define connectivity forest (CFs) as forests outside recognized high conservation
Denna text lyfter stöd kring urban dagsljusplanering utifrån effekter på medborgarnas allmänna hälsa och livskvalitet och utifrån energieffektiva byggnader och städer. Urban dagsljusplanering kan minska vårt beroende av belysning och kan därmed vara en nyckelfaktor för att främja energibesparing och göra bebyggelsen mer resilient.
Developing high-performance, low-cost oxygen evolution reaction (OER) catalysts is crucial for advancing anion exchange membrane water electrolysis (AEMWE) in large-scale industrial green hydrogen production. Herein, We report a glucose-mediated spray pyrolysis method for synthesizing amorphous NiFe bimetal oxide hollow microspheres (A-NiFeOx) with controlled crystallinity, hierarchical porosity,
Background: To compare echocardiographic and cardiac magnetic resonance imaging (CMR) measurements of global longitudinal strain (GLS) and global mitral annular plane displacement in women with breast cancer undergoing chemotherapy. The study focused on assessing the mitral annular plane systolic excursion (MAPSE) in echocardiography (ECHO) and atrioventricular plane displacement (AVPD) in CMR as
BACKGROUND: The evidence linking sugar intake to cardiovascular disease risk remains largely inconclusive, with variations observed across different subgroups of sugar intake. In addition, studies on genetic markers of sugar intake are scarce, especially for different sugar subgroups.OBJECTIVE: This genome-wide association study (GWAS) aimed to investigate genetic variants associated with the inta
Measurements of the Higgs boson production times decay rates and differential cross-sections have recently been performed by the ATLAS experiment in several decay channels using up to 139 fb−1 of proton-proton collision data at s = 13 TeV recorded at the Large Hadron Collider. This paper presents multiple interpretations of these Higgs boson measurements. Measurements of production-mode cross-sect
