The human kallikrein (hk) family, located on chromosome 19, encodes prostate-specific antigen (PSA [or hK3]), hK2, hK4, and hK15 (prostin), as well as other serine proteases. Although PSA has been used in the detection of prostate cancer for several years, much remains unknown about its function and forms. The regulatory mechanisms of PSA are vital to its understanding. A particular mechanism by w

Haemodilution is commonly used as prophylaxis, as well as treatment for cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). Thirty-six patients operated for aneurysmal SAH were evaluated retrospectively; 24 received haemodilutive therapy and 12 patients, as a control group, received no additional therapy. There was a 'spontaneous' drop in haematocrit by 22% in both groups, and a co

A multiwell tissue culture system was developed to study the influence of various substances on hepatitis A virus (HAV) propagation. A panel of 20 substances of different structure types, each with known effect against at least some viruses, was studied at a concentration of 100 microM. Three substances showed reproducible inhibition. The strongest inhibitor, arabinosylcytosine, also produced cyto

The angels still do not know how to sing during Christmas night. Some have three lines in Luke 2.14, others only two. Some have good liturgical hymns in their textbooks, others must use bad prose versions. This article reconstructs a Hebrew version with its focus on the righteous remnant of Israel, the "Anawim" in Jerusalem who saw Jesus as the beginning of the restoration of Israel, and goes on t

Objective: The novel axial flow left ventricular assist device HeartMate II was introduced into clinical practice in Europe as part of the pilot study and after CE approval in November 2005. In order to get an overview of the use and performance of the device in Europe a group of investigators was founded to compare the initial results. Methods: In a retrospective analysis of the first 101 consecu

In Sweden, Jurassic strata are restricted to Skåne and adjacent offshore areas. Jurassic sedimentary rocks predominantly comprise sandy to muddy siliciclastics, with subordinate coal beds and few carbonate-rich beds. During Mesozoic times, block-faulting took place in the Sorgenfrei– Tornquist Zone, a tectonic zone which transects Skåne in a NW–SE direction. The Jurassic depositional environments

This paper proposes a simple procedure to reduce the size distortions of the panel LM test for cointegration. The new procedure is based on first splitting the sample into even and odd numbered observations, and to employ the panel LM test to each subsample. The two tests are then combined using the Bonferroni principle as suggested by Choi [Choi, I., 2004, Improving the empirical size of the KPSS

In hereditary cystatin C amyloid angiopathy (HCCAA), presence of the Leu68 Gln substitution in cystatin C is coupled to a decreased concentration of this major cysteine proteinase inhibitor in cerebrospinal fluid and leads to its amyloid deposition in the brain. We established a high-yield expression system for L68Q cystatin C in Escherichia coli resulting in inclusion body accumulation at a level

C-CAM (Cell-CAM 105) is a cell surface glycoprotein that is involved in cell-cell adhesion of rat hepatocytes in vitro. To elucidate the adhesion mechanism the binding properties of purified C-CAM were investigated. Using proteins immobilized on nitrocellulose it was found that radiolabeled C-CAM bound to C-CAM but not to a variety of other proteins. Partitioning in Triton X-114 showed that C-CAM

The physical nature of water and the environment it presents to an organism have long been recognized as important constraints on aquatic adaptation and evolution. Little is known about the dermal cover of mosasauroids (a group of secondarily aquatic reptiles that occupied a wide array of predatory niches in the Cretaceous marine ecosystems 92-65 Myr ago), a lack of information that has hindered i

A new method is proposed for the computation of CO2 Net Ecosystem Exchange (NEE) and its components in a forest ecosystem. Advective flux is estimated by taking into account the air mass conservation principle. For this purpose, wind and dry air density values on the surface of the control volume are first corrected and then the advective flux is estimated on the surface of the control volume. Tur

Oocytes obtained from 85 women undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment were randomly selected for culture in media containing either human serum albumin (HSA), (n = 42) or recombinant human albumin (rHA), (n = 43). At the time of transfer, the two embryos with the overall best morphology were selected on day 2, 3 or 5. Comparable rates of fertilization, cleavage, blastocys

The hottest developments in the fields of cancer research, neuroscience, genomics and proteomics, anti-virals and more, with a pick of the key research papers in these areas.

The lifetime of the metastable level 3d(21)G(4) in a singly charged scandium has been experimentally investigated at the ion storage ring CRYRING. A laser probing technique has been used for the studies. We also report calculated lifetimes and transition rates for 10 metastable levels in Sc II, including the 3d(21)G(4) state, by calculations using configuration interaction wave functions. The life

Recent findings in adult rodents have provided evidence for the formation of new striatal neurons from subventricular zone (SVZ) precursors following stroke. Little is known about which factors determine the magnitude of striatal neurogenesis in the damaged brain. Here we studied striatal neurogenesis following an excitotoxic lesion to the adult rat striatum induced by intrastriatal quinolinic aci

This study was part of a Swedish interdisciplinary research project targeting accessibility problems in public transport for people with cognitive functional limitations (CFLs). The objective was to describe and compare different assessment perspectives of long-term CFLs among community citizens having had CFLs in the acute stroke phase but with moderate physical limitations. Eighty-four participa

A novel and a simple method that allows direct imaging of viscous samples by cryo-TEM (cryo-transmission electron microscopy) is presented. A fracture on the vitrified sample is created in a controlled way. In the fracture, some edges are thin enough to allow direct imaging in transmission mode. The method was used to directly image a nonionic surfactant lamellar phase where a random mesh structur

Recent comparative observations of long-duration gamma-ray bursts (LGRBs) and core collapse supernova (cc SN) host galaxies demonstrate that these two, highly energetic transient events are distributed very differently upon their hosts. LGRBs are much more concentrated on their host galaxy light than cc SN. Here we explore the suggestion that this differing distribution reflects different progenit