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Machine and reinforcement learning (RL) are increasingly being applied to plan and control the behavior of autonomous systems interacting with the physical world. Examples include self-driving vehicles, distributed sensor networks, and agile robots. However, when machine learning is to be applied in these new settings, the algorithms had better come with the same type of reliability, robustness, a
In this paper we consider adaptive distributed stabilization for uncertain multivariable linear systems with a time-varying diagonal matrix gain. We show that an unknown system matrix being an M-matrix is a sufficient condition to ensure uncertain linear systems to be stabilizable by matrix high gains, and derive a threshold condition to ensure exponential stability of uncertain linear systems sta
This thesis consists of five papers concerned with the modeling of stochastic signals, as well as deterministic signals in stochastic noise, exhibiting different kinds of structure. This structure is manifested as the existence of finite-dimensional parameterizations, and/or in the geometry of the signals' spectral representations. The two first papers of the thesis, Papers A and B, consider the m
In the twentieth century, national self-determination came to be regarded as a basic human right. This concept served as the ideological foundation for both the establishment of successor states in Central and Eastern Europe after World War I and the decolonization of the Third World after World War II. All the problems were brought into focus by the new wave of ethnic nationalism that began in Ce
The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have adopted various tax policy measures in order to confront the current economic crisis caused by the downscale of their domestic economies. Despite their common characteristics (size, economic situation, institutional settings), the Nordic countries have adopted different strategies to limit the detrimental effects of the cris
During recent decades, there has been a substantial development in optimal mass transport theory and methods. In this work, we consider multi-marginal problems wherein only partial information of each marginal is available, a common setup in many inverse problems in, e.g., remote sensing and imaging. By considering an entropy regularized approximation of the original transport problem, we propose
Aims: The TTM2-trial is a multi-centre randomised clinical trial where targeted temperature management (TTM) at 33 °C will be compared with normothermia and early treatment of fever (≥37.8 °C) after Out-of-Hospital Cardiac Arrest (OHCA). This paper presents the design and rationale of the TTM2-trial follow-up, where information on secondary and exploratory outcomes will be collected. We also prese
The influence of the Sc cation substituent on the structural and luminescence properties of GAGG:Ce crystals was studied. Unit cell parameters and space groups were obtained using XRD analysis. The chemical compositions of the crystals were determined using SEM-EDX and TEM-EDX techniques. Structures were refined by the Rietveld method and the distribution of Al/Ga/Sc cations between octahedral and
Aim: The aims of this study were to evaluate health-related quality of life (HRQoL) in children with sacrococcygeal teratoma and to explore the effect of the scar on physical, emotional and behavioral aspects. Methods: A cohort of children operated on for sacrococcygeal teratoma between 2000 and 2013 at Lund University Hospital, Sweden, and their parents were interviewed. HRQoL was evaluated with
Background: Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic cancer is still often synonymous with a fatal outcome. The term periampullary cancer includes pancreatic cancer and applies to the group of tumours found in proximity to the ampul
Despite considerable progress in schizophrenia genetics, most findings have been for large rare structural variants and common variants in well-imputed regions with few genes implicated from exome sequencing. Whole genome sequencing (WGS) can potentially provide a more complete enumeration of etiological genetic variation apart from the exome and regions of high linkage disequilibrium. We analyze
Background: The pathophysiology of septic acute kidney injury is inadequately understood. Recently, subphenotypes for sepsis and AKI have been derived. The objective of this study was to assess whether a combination of comorbidities, baseline clinical data, and biomarkers could classify meaningful subphenotypes in septic AKI with different outcomes. Methods: We performed a post hoc analysis of the
Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatment delivered via the Breezhaler® device for the treatment of patients with asthma. In this randomized (n = 116), double-blind, double-dummy, active comparator-controlled, three-period cross-o
Many workers are exposed to heat stress that can be exacerbated by the type of clothing they wear. The resulted heat strain can lead to short or long-term heat-related disorders. This study aimed to measure clothing properties of sugarcane field workers and evaluate the heat strain by an international standard, predicted heat strain model (PHS). The clothing thermal insulation and evaporative resi
Small interfering RNAs (siRNAs) are a new class of promising therapeutic molecules that can be used for sequence-specific downregulation of disease-causing genes. However, endosomal entrapment of siRNA is a key hurdle for most delivery strategies, limiting the therapeutic effect. Here, we use live-cell microscopy and cytosolic galectin-9 as a sensor of membrane damage, to probe fundamental propert
