Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. Despite promising results in preclinical models, the benefits for patients proved to be limited.

Lubna Hawwa och Andreas Mattsson om religiös extremism och förtryck på Maldiverna

This work represents a critical re-examination of the application of dynamic light scattering (DLS)–based tracer particle microrheology to measure the zero shear viscosity of aqueous solutions of different proteins up to very high concentrations. It is demonstrated that a combination of surface-functionalized tracer particles, the use of the so-called 3D-DLS technique, and carefully chosen paramet

På kort tid har Kina fått över 300 miljoner mikro­bloggare. På nätet sprids förutom skvaller och rykten även skarp kritik mot kommunistpartiet. Den kinesiska staten har fått en utmanare i kampen om informationen.

Den här uppsatsen låter sex unga journalister komma till tals med avseende på hur de tänker kring förhållandena på arbetsmarknaden. Syftet är att med hjälp av en kvalitativ intervjustudie belysa hur unga journalister tänker kring sin karriär, framtid och livet vid sidan av yrket.Arbetsgivarna inom mediebranschen tillhör dem som i störst utsträckning kringgår lagen om anställningsskydd (LAS). Det i

Changes to agricultural systems in Sub-Saharan Africa are subject to a wide range of drivers, often resulting in rapid and nonlinear dynamics. Such dynamics are however rarely recognized in studies of trends and drivers, which usually rely on assumptions of gradual progressions, and often using highly aggregated data. This paper addresses this lack of recognition and understanding of nonlinear pro

Quinolines, indolizines, and coumarins are well known structural elements in many biologically active molecules. In this report, we have developed straightforward methods to incorporate quinoline, indolizine, and coumarin structures into galactoside derivatives under robust reaction conditions for the discovery of glycomimetic inhibitors of the galectin family of proteins that are involved in immu

Introduction: The demographic changes with population ageing and a rapidly growing share of very old peoplewill put an increasing pressure on the health and social care system. In order to both restrict early retirement and force people to extend their working life reforms are changing pension systems in many European countries. Besides that older people have to extend their working life it is imp

The report summarises a small case study in which two research groups were interviewed and observed as they were planning, conducting and analysing experiments at MAX IV Laboratory.The aim of the study was to identify the current research data management practices of the scientists, and to connect this to how these practices are supported by MAX IV.The report summarises a small case study in which two research groups were interviewed and observed as they were planning, conducting and analysing experiments at MAX IV Laboratory.The aim of the study was to identify the current research data management practices of the scientists, and to connect this to how these practices are supported by MAX IV.

Institutions for prevention and resolution of industrial conflicts were introduced all over the world in the early twentieth century. We use a new dataset of geocoded strikes and lockouts to analyze the impact of mediation on conflict outcomes in Sweden for the period 1907–1927. Causality is identified by using the distance from the mediator’s place of residence to the conflict as an instrument. D

Background: Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups. Objectives: To investigate the relationshi

Despite the clinical development of novel adjuvant and neoadjuvant chemotherapeutic drugs, metastatic breast cancer is one of the leading causes of cancer-related death among women. The present review focuses on the relevance, mechanisms, and therapeutic potential of targeting WNT5A as a future anti-metastatic treatment strategy for breast cancer patients by restoring WNT5A signaling as an innovat

Importance: Childhood appendicitis is commonly complicated by gangrene and perforation, yet the causes of complicated appendicitis and how to avoid it remain unknown. Objective: To investigate whether children with IgE-mediated allergy have a lower risk of complicated appendicitis. Design, Setting, and Participants: This retrospective cohort study included all consecutive patients younger than 15

Previous research has made three parallel but incompatible observations on the contemporary development of welfare professions: loss of professional autonomy, hybridization, and maintained autonomy. Yet, research providing contextual understanding of the simultaneous occurrence of these three observations is lacking. The aim of this theoretical paper is to identify and explain seemingly contradict

Cellulose nanocrystal (CNC) incorporation in polymeric matrices is an environmentally friendly approach to mechanical reinforcement. In general, significant mechanical reinforcement can only be achieved by means of good CNC dispersion at random orientation. These primary characteristics are even more relevant for the preparation of nanocomposites based on hydrophobic matrices, such as poly(ε-capro

The extraction, supply, market price and recycling of the metals molybdenum and rhenium were modelled using an integrated system dynamics model. The resource estimates made here resulted in significantly larger estimates than earlier studies for molybdenum. Present molybdenum resources are about 75–80 million ton and about 7 million ton has been mined to date. The ultimately recoverable resources