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Continuous glucose monitors (CGMs) provide detailed glucose profiles, but their relevance to health outcomes in individuals without diabetes remains unclear. Here we assess time in range (TIR3.9–5.6 and TITR3.9-7.8) and glycaemic variability in individuals (N = 3,634; age 46 ± 12 y; 83% female; BMI 27 ± 6 kg/m²) from PREDICT 1 (NCT03479866), PREDICT 2 (NCT03983733), and PREDICT 3 (NCT04735835) wit
Purpose: Secondary brain injury is a common cause of poor outcome after trauma, subarachnoid hemorrhage, and intracerebral hemorrhage, and optimizing treatment requires real-time insight into cerebral metabolism. Cerebral microdialysis (CMD) uniquely provides key related information, yet consensus on its use has not been updated since publication of the consensus statement from the 2014 Internatio
Between 1966 and 1996, French nuclear testing in French Polynesia was justified through a recurring promise/threat nexus that linked strategic necessity to development while producing enduring social and environmental harms. Presidential speeches delivered in Tahiti by Charles de Gaulle, François Mitterrand, and Emmanuel Macron illuminate how the test site and its aftermath have been governed thro
In this book, Metzinger develops a theory of pure consciousness, while presenting empirical findings from more than 500 experiential reports from practitioners of meditation. Pure consciousness is what we experience when we attend to awareness itself – when attention is refocused to the normally unnoticed medium through which we experience the world. The practice of meditation is likely to facilit
Biological tissues are complex, dynamic and inherently three-dimensional systems whose physiological and anatomical organization is shaped by their native structural and molecular context. Recent advances in three-dimensional and label-free imaging are transforming our ability to interrogate complex biological specimens across molecular, cellular, and organ scales. However, many conventional imagi
How did colonial fiscal systems respond to economic crisis, and what were the distributional consequences of those responses? This paper examines fiscal policy and inequality in the Gold Coast during the Great Depression using newly reconstructed tax revenues and expenditure data linked to social tables. It estimates the tax burden relative to income, the sectoral incidence of taxation, and the re
Tiden tas ofta för given. Men de sätt på vilka den uppfattas och uttrycks är aldrig neutrala eller förutbestämda – de är resultatet av specifika erfarenheter, kunskaper och önskningar. Mot bakgrund av konkurrerande värderingar och förväntningar på den boreala skogen i ljuset av klimatförändringar och resurspåfrestningar undersöker denna avhandling hur förståelser, erfarenheter och tolkningar av tiTime is often taken for granted. However, the ways in which it is perceived and expressed are never neutral or pre-given - they are the result of particular experiences, knowledges and desires. In the context of competing values and expectations for the boreal forest in the face of climate change and resource pressures, this thesis investigates how understandings, experiences and framings of time
Om hippierörelsen.
Post-growth science seeks to meet human needs equitably for all within the planet’s ecological limits, independent of GDP growth [1]. We propose that developing sector-specific post-growth visions, for example, in healthcare, energy, food, housing, education, or recreation, can help translate post-growth principles into concrete and relatable futures. Communicating such visions can broaden public
We study the relationship between the structural transformation of the economy and the income distribution, focusing on the case of Sweden from 1870 to 1970, with extra attention paid to the 1870–1950 period, for which we produce extensive new data. Average income increased fivefold between 1870 and 1950, and the share employed in agriculture declined from 72 to 23 per cent. To study the evolution
With osteoarthritis progression, both mechanical and structural changes of articular cartilage occur. However, little is known about the interaction between the two. Digital volume correlation (DVC) could theoretically provide such insight, extracting the internal strain field from computed tomography (CT) datasets of the tissue under load. A recent study highlighted the possibility of time-resolv
BACKGROUND: Atrial fibrillation (AF) burden is associated with adverse outcomes; in some patients, very low AF burden may not be actionable.OBJECTIVE: This study aimed to model AF burden as a function of monitoring time without AF.METHODS: We included 11,639 US patients (median age 62 years [interquartile range 46‒73], 40.6% male) without permanent/persistent AF, monitored for ≥14 days in 2021 wit
The efficient clearance of IAPP oligomers (IAPPo) by autoantibodies is crucial as increased plasma levels of IAPPo can induce microvascular alterations and Alzheimer's disease (AD)-characteristic amyloid-β deposition in the brain. We have recently demonstrated that plasma immunoglobulin (Ig) A levels against IAPPo, but not IgG, are reduced in an Apolipoprotein E (APOE) ε4 allele dose-dependent man
BACKGROUND: Clinical practice guidelines are intended to help with decision-making. However, their quality differs. Guidelines of low quality are a waste of resources and can cause patient harm. We compared the quality of the Danish, Norwegian, and Swedish guidelines on papillary thyroid cancer (PTC) with those of the American Thyroid Association (ATA, 2015 version).METHODS: Three pairs of apprais
Malignant ventricular arrhythmias (VAs) are a major contributor to mortality in myocardial infarction. Although early revascularization has markedly reduced the incidence of late and secondary VA, the occurrence and fatality rates of VA during the prehospital stage remain high. In ST-segment elevation myocardial infarction, most VAs occur within the first 24 hours, with only a small proportion obs
Pilar leiomyoma is a rare benign tumour that derives from the arrector pili muscle. Due to its rarity, the dermatoscopic features of pilar leiomyoma are scarcely reported in the literature. Herein, we report a further case of pilar leiomyoma that highlights its dermatofibroma-like dermatoscopic features and underscores that, despite advances in noninvasive imaging technologies, histopathology rema
