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Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of C

The performance of 2.7 mu m superficially porous particles at 600 bar and sub-2 mu m fully porous particles at 1000 bar were compared by the Poppe plot method. Theoretical Poppe plots were first constructed for each stationary phase to compare their kinetic performance at different analysis times. The theory was then verified by experiments under the optimized conditions identified from the Poppe

Denna rapport är resultatet av en litteraturstudie där olika faktorers påverkan på gåendet och cyklandet i en urban kontext har undersökts. Utifrån det studerade materialet har faktorerna delats in i grupperna individuella, externa samt resspecifika faktorer. Beslutsprocessen för genomförande av gång- och cykelresor har delats in i faserna resbeslut, färdmedelsval och vägval. De studerade publikat

This paper explores how vehicle speeds are related to equitable, environmental, and economic sustainability of urban areas. This relationship is manifested primarily through associations between vehicle speeds and road crash casualties, severity of pedestrian crashes, generation of harmful emissions, and relative desirability of neighboring land. Reported research findings describing these associa

To efficiently provide an animal with relevant information, the design of its visual system should reflect the distribution of natural signals and the animal’s tasks. In many behavioural contexts, however, we know comparatively little about the moment-to-moment information-processing challenges animals face in their daily lives. In predator avoidance, for instance, we lack an accurate description

This report uses a relational theory of risk within which risk is understood as a relationship between a risk object and an object at risk where the risk object threatens the value embedded in the object at risk. A case study of risk management in railway planning examined through a relational understanding of risk demonstrates how riskwork is conditioned by what is valued, how, and by whom. The r

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type

OBJECTIVES: Cyclophosphamide (CP) is an alkylating agent classified as a human carcinogen. Health care workers handling this drug may be exposed during, e.g., preparation or administration. Cyclophosphamide is readily absorbed by inhalation and by dermal uptake. A biomarker, CP in urine, has frequently been used to assess the occupational exposure to CP, but has not been fully validated. The aim o

Software failures in medical devices can lead to catastrophic situations. Therefore is it crucial to handle software related risks when developing medical devices. This paper presents the experiences gained from an ongoing case study with a medical device development organisation. This part of the study focuses on the two first steps of the risk management process, i.e. risk identification and ris

Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on A

We present a network of sites across Fennoscandia for optical sampling of vegetation properties relevant for phenology monitoring and satellite data calibration. The network currently consists of five sites, distributed along an N-S gradient through Sweden and Finland. Two sites are located in coniferous forests, one in a deciduous forest, and two on peatland. The instrumentation consists of dual-

Colorectal cancer (CRC) is one of the most common forms of human cancer worldwide with approximately 1 million new cases detected every year. CEA is currently the only accepted CRC marker incorporated into clinical practice, where it is used for early detection of metastasis in follow-up of patients having stage II and III disease, and for monitoring response to adjuvant treatment. However there a

Objective. Overactive bladder (OAB) is a chronic condition that has a profound impact on health-related quality of life (HRQoL). This study measured changes in bother of OAB symptoms and self-perceived HRQoL over 6 months in patients treated with extended-release (ER) tolterodine in a naturalistic setting. Material and methods. This was a prospective, single-cohort observational study of patients

The use of nanoparticles in consumer products, for example, cosmetics, sunscreens, and electrical devices, has increased tremendously over the past decade despite insufficient knowledge about their effects on human health and ecosystem function. Moreover, the amount of plastic waste products that enter natural ecosystems, such as oceans and lakes, is increasing, and degradation of the disposed pla

Organometal halide perovskite-based solar cells have recently been reported to be highly efficient, giving an overall power conversion efficiency of up to 15%. However, much of the fundamental photophysical properties underlying this performance has remained unknown. Here, we apply photoluminescence, transient absorption, time-resolved terahertz and microwave conductivity measurements to determine

Contemporary precipitation patterns in the Caribbean region are spatially variable, and the small number of Holocene paleoclimatic records may not adequately capture patterns of variation in the past. The hydrological history of Grenada was inferred from paleolimnological analyses of sediment cores from two crater lakes on the island. The basins were formed by volcanic activity some time during th