Background: To further understand the role of pituitary adenylate cyclase-activating polypeptide 1 (PAC1) receptors in headache disorders, we mapped their expression in tissues of the trigemino-autonomic system by immunohistochemistry and in situ hybridization. Methods: To optimize screening for monoclonal antibodies suitable for immunohistochemistry on formalin-fixed, paraffin-embedded tissues, w

Background: There is a growing need to support the health and wellbeing of older persons aging in the context of migration. Objectives: We evaluated whether a group-based health promotion program with person-centred approach, maintained or improved life satisfaction and engagement in activities of older immigrants in Sweden. Methods: A randomised controlled trial with post-intervention follow-ups

Light Sheet Fluorescence Microscopy (LSFM) of whole organs, in particular the brain, offers a plethora of biological data imaged in 3D. This technique is however often hindered by cumbersome non-automated analysis methods. Here we describe an approach to fully automate the analysis by integrating with data from the Allen Institute of Brain Science (AIBS), to provide precise assessment of the distr

As the formal work of the IWA Task Group on Benchmarking of Control Strategies for Wastewater treatment Plants (WWTPs) has come to an end, it is essential to continue to disseminate the intense research in this field that is still carried out. In 2013 and 2014, all authors of the IWA Scientific and Technical Report on benchmarking came together to provide their insights, highlighting areas where k

Continuously operated settling tanks are used for the gravity separation of solid-liquid suspensions in several industries. Mathematical models of these units form a topic for well-posedness and numerical analysis even in one space dimension due to the spatially discontinuous coefficients of the under- lying strongly degenerate parabolic, nonlinear model partial differential equation (PDE). Such a

Background: The incidence of cancer has steadily risen. It is important to identify modifiable predictors in early life that may decrease cancer risks and mortality. The present study aims to investigate the relationship between aerobic fitness in adolescence and the subsequent risk of cancer and cancer-associated mortality. Methods: The study included 1 185 439 Swedish men born between 1950 and 1

Subarachnoid hemorrhage (SAH) is associated with increased cerebral artery sensitivity to vasoconstrictors and release of the perivascular sensory vasodilator CGRP. In the current study the constrictive phenotype and the vasodilatory effects of exogenous and endogenous perivascular CGRP were characterized in detail applying myograph technology to cerebral artery segments isolated from experimental

Background: The main aim of the present population-based study was to compare drugs in fall versus non-fall accidents causing major trauma, including both clinical and medico-legal autopsy data. Methods: All individuals with accidents resulting in major trauma, a new injury severity score (NISS) > 15 or lethal outcome was identified at hospital and/or the Department of Forensic Medicine between 20

Researching intimacies and new media encompasses a wide variety of intersecting practices and relationships. This special issue presents contributions from researchers who are investigating practices of intimacy mediated either wholly or in part through new media in which a variety of different methodological opportunities and challenges are highlighted and discussed. Existing research has address

Festskriften till Håkan Hydén uppmärksammar att det 2018 är 40 år sedan Hydén disputerade, 30 år sedan Hydén blev professor i rättssociologi vid Lunds universitet och 10 år sedan Hydén blev innehavare av professuren till minne av Samuel von Pufendorf vid samma universitet. Festskriften innehåller bidrag från ca 60 forskare från olika universitet, från flera olika länder och med flera olika ämnesti

Kapitlet beskriver hur kritiken mot den straffrättsliga behandlingstanken formulerades av dåtidens radikala jurister och hur feministisk kritik mot av- och nedkriminalisingar på sexualbrottsområdet kom att forma ett kriminalpolitiskt perspektivskifte. Utgångspunkten är att 1970-talet utgör en kriminalpolitisk vändpunkt och att det därför är viktigt att återkommande reanalysera genom närläsningar a

Personers riskuppfattning påverkas av flera faktorer, som närheten till tidigare händelser, egna erfarenheter (utbildning och social kontext) och vad som kommuniceras. Detta innebär att både budskapsgivaren och mottagaren har stor betydelse för hur en kommunikationssituation utvecklas.Syftet med detta delprojekt, som är en del av projektet ”Nätverk vid upptäckt av befolkningsexponering fo

Background: The persistent environmental contaminants perfluoroalkyl substances (PFASs) have gained attention due to their potential adverse health effects, in particular following early life exposure. Information on human fetal exposure to PFASs is currently limited to one report on first trimester samples. There is no data available on PFAS concentrations in fetal organs throughout all three tri

About one third of the food produced globally is wasted along the food chain, representing a burden for the environment and an inefficiency of the food system. Tackling food waste is a priority on the global political agenda to guarantee food security. Defining a methodology for food waste quantification is key to monitoring progress towards the achievement of reduction targets. This paper summari

Objectives: Nailfold capillaroscopy is being increasingly used by rheumatologists in the diagnosis of SSc. However, assessment of all nailfolds can be time-consuming in a busy outpatient clinic. Our aim was to answer the question as to how many (and which) fingers a clinician should routinely assess to capture accurately the true state. Methods: A total of 2994 assessments (by an international pan

Background and Purpose- We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods- Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/GISCOME (Genetics of Ischaemic Stroke Fu

Skeletal stem cells (SSCs) are present in bone marrow (BM) and offer great potential for bone regenerative therapies. However, in the absence of a unique marker, current sorting approaches remain challenging in the quest for simple strategies to deliver SSCs with consistent regeneration and differentiation capacities. Microfluidics offers the possibility to sort cells marker-free, based on intrins