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Background: Although alcohol use disorder (AUD) runs strongly within families, studies examining the impact of rearing environment, unconfounded by genetic effects, are rare and, to date, contradictory. We here seek to conduct such a study using an adoptive co-sib control design. Methods: Defining high-risk as having 3/41 biological parent with an externalizing syndrome (AUD, drug abuse or crime),

An established MP2RAGE protocol for semi-quantitative structural brain MRI was transferred from one 7T MR scanner to that of another vendor featuring comparable hardware, but opposite polarity. On this system, the scan time could be reduced from 11 to 8 minutes, mainly by elliptical k-space sampling. Three configurations of radio-frequency (RF) transmission were compared (single channel with quadr

Although the use of induction therapy has reduced the risk of acute rejection after heart transplantation, its use may be associated with other adverse outcomes. We aimed to examine the effect of no induction (NoInd), induction with basiliximab (BAS), or induction with antithymocyte globulin (ATG) on outcome after heart transplantation. We analyzed data from the International Society for Heart and

Background: Drug abuse is frequently associated with negative sequelae such as reduced socioeconomic functioning. The extent to which these associations are attributable to a causal role of the disorder versus confounding factors that increase risk for both drug abuse and negative socioeconomic outcomes is unclear. Methods: Drug abuse cases were identified using Swedish national medical, pharmacy,

In a future climate change perspective, the interactions among different life-forms of primary producers will likely be altered, leading to changes in the relative dominance among macrophytes, filamentous, and planktonic algae. In order to improve the possibilities to forecast future ecosystem services and function, we therefore conducted a long-term mesocosm study where primary producers were exp

Objective: To clarify the preclinical stage of Alzheimer’s disease by estimating when β-amyloid accumulation first becomes associated with changes in cognition. Methods: Here we studied a large group (N = 4432) of cognitively unimpaired individuals who were screened for inclusion in the A4 trial (age 65–85) to assess the effect of subthreshold levels of β-amyloid on cognition and to identify which

The aim of this study was to evaluate the use of optical coherence tomography (OCT) to identify and assess visual field defects caused by primary damage to the optic radiation in individuals with spastic cerebral palsy (CP). Ten individuals with spastic CP (six females, four males, with a median age of 21 years [range 17–38y]) had their brain lesions documented with conventional magnetic resonance

Background: Assessing and communicating software engineering research can be challenging. Design science is recognized as an appropriate research paradigm for applied research, but is rarely explicitly used as a way to present planned or achieved research contributions in software engineering. Applying the design science lens to software engineering research may improve the assessment and communic

Cold intolerance and pain can be a substantial problem in patients with peripheral nerve injury. We aimed at investigating the relationships among sensory recovery, cold intolerance, and neuropathic pain in patients affected by upper limb peripheral nerve injury (Sunderland type V) treated with microsurgical repair, followed by early sensory re-education. In a cross-sectional clinical study, 100 p

This article examines the citizenship dimension of transnational inequalities. It is clear that some citizenships offer great advantages while others are liabilities for the individual, and the aim of this present article is to develop a conceptualisation of citizenship and inequality, in order to be able to assess and compare them. For this purpose, elements of Pierre Bourdieu's sociology are uti

This update of the Xg blood group system (Johnson NC. XG: The forgotten blood group system. Immunohematology 2011;27:68-71) notes the identification of a cis-regulatory element of both XG and CD99 expression, remarkably by two independent groups during 2018, and confirmed by another in 2019. A single nucleotide change at the XG locus (rs311103) abolishes GATA1 binding and suppresses both XG and CD

Purpose: Surgery is recommended for most patients with gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NENs). Rates of complications and perioperative mortality have been reported in few mostly retrospective single-center series, but there has been no detailed analysis on risk factors for perioperative complications and mortality to date. Methods: Data of patients with GEP-NENs operated be

Are people more likely to become more politically active through social media when they observe that their friends are active? Previous research has shown that an individual's likelihood of engaging politically is influenced by observations of how friends act through social media, but relatively little is known about how such social influence through social media interacts with personality feature

Fashion upcycling, the process of using waste clothing and textiles to create new products, is an alternative to business-as-usual practices which can effectively address concerns on excessive consumption of energy and material resources and use of chemicals in the fashion industry. Scaling up fashion upcycling businesses could enable the transition of the fashion industry towards sustainability.

The saccharification of lignocellulosic materials like Norway spruce is challenging due to the recalcitrant nature of the biomass, and it requires optimized and efficient pretreatment and enzymatic hydrolysis processes to make it industrially feasible. In this study, we report successful enzymatic saccharification of sulfite-pulped spruce (Borregaard's BALI™ process) at demonstration scale, achiev

Background: The implementation of screening programmes in Sweden during the mid-1990s increased the number of small node-negative breast cancers. In this era before staging by sentinel node biopsy, routine axillary dissection for staging of early breast cancer was questioned owing to the increased morbidity and lack of perceived benefit. The long-term risk of axillary recurrence when axillary stag

Background: Long-term outcomes of patients admitted to intensive care units (ICUs) after surgery are unknown. We investigated the long-term effects of surgical exposure prior to ICU admission. Methods: Registry-based cohort study. The adjusted effect of surgical exposure for mortality was examined using Cox regression. Secondary analysis with conditional logistic regression in a case-control subpo

Enligt flera definitioner av det något lösa samtida begreppet ”hybridkrigföring”, i betydelsen primärt mellanstatliga konflikter av den typ som utspelade sig på Krim 2014 och i östra Ukraina sedan 2015, är underrättelsekomponenten en central resurs för den angripande parten. Detta öppnar upp en ny roll för kontraspionaget, som utöver sina traditionella uppgifter nu också måste ha beredskap att bem