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Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at
In our increasingly digitalized society, it is important to have a grasp of basic programming and therefore, programming was recently made mandatory in Swedish schools. We investigated how the mandatory programming education affects self-efficacy and interest in programming in a sample of 12-year-old children (N = 373). Data was collected at the start of the school year, directly after the educati
Background and purpose — Stress fractures of the femoral neck (sFNFs) are uncommon injuries. Studies on sFNFs are rare. We describe the demographics, classification, treat-ment, reoperation rates, and mortality in a cohort of sFNF patients from the Swedish Fracture Register (SFR). Patients and methods — We included 146 patients ≥ 18 years of age with an sFNF registered in the SFR between 2011 and
Significance This project describes the existence of previously unknown non-GPI-anchored CD59 isoforms required for insulin secretion, named CD59-IRIS-1 and CD59-IRIS-2, and finds reduced expression of CD59-IRIS isoforms in human diabetic islets, showing a link between dysregulation of IRIS isoforms and defects in insulin secretion in diabetic patients. These data open a path for future studies in
In this presentation I will discuss the potential of narrative methods to remedy the epistemic injustice that drug users experience within the drug-averse Swedish context, departing from my work with drug-involved women in Sweden. Drug users and, more generally, drug-active individuals have been traditionally considered as unreliable sources of information, requiring the researcher to spend consid
Zinc is an element of importance in many research fields within astronomy and astrophysics, from cosmology to stellar atmosphere dynamics. With the aim of improving three decades old measurements of zinc lines of astrophysical interest, emission spectra of Zn I and Zn II have been recorded using a Fourier Transform Spectrometer with a hollow cathode light source. Revised energies for previously kn
This letter proposes a co-designed millimeter-wave (mm-wave) and sub-6GHz antenna system. The antenna system consists of four 28GHz mm-wave arrays with reconfigurable radiation patterns and two sub-6GHz antennas fed with two corner capacitive coupling elements (CCEs). Each corner CCE is formed by the connected ground planes of two mm-wave arrays in the shared-aperture configuration. The two CCEs a
Sufficiency has long been marginalized in the public and political sustainability discourse. Since attempts to reduce CO2 emissions in the long term have so far fallen short of expectations, sufficiency has recently approached the forefront of scientific and social debates about a »good life«. In addition to a strict reduction target, the sufficiency strategy promises psychological well-being and
With stringent effluent requirements and the implementation of new processes for micropollutant removal, it is increasingly important for wastewater treatment plants (WWTPs) to understand the factors affecting effluent quality. Phages (viruses infecting prokaryotes) are abundant in the biological treatment processes. They can contribute to organic carbon in the treated effluent both because they a
Mylla is an intermedial stage production that addresses our emotional, economic and vital relationship with the earth and how it is changing. The performance drew on interviews with farmers in the Skåne region in Sweden. Mylla unites Liv Kastrup Vesterskov (idea, direction), Halla Steinunn Stefánsdóttir (sound design, composition), Gylleboverket (scenography) and Adam Knapasjö (dramaturgy) and imp
The calendar disk of the fifteenth century astronomical clock in the church of Saint Mary in Gdansk (Poland) contains a wealth of astronomical and calendrical data. We make a statistical analysis of the mean conjunction times of all the mean New Moons as represented on the disk for four Metonic 19-year cycles. We find that the conjunction times were generated using the Alfonsine value for the leng
This book brings together several outstanding authors in the field and covers questions relating to the fundamental milestones in technology development and governance (Judit Sandor), an analysis of disability questions and empowerment of the community (Pin Lean Lau), right to health opportunities and challenges (Anne Kjersti Befring), the protection of the right to private life and life (Merel M.
This research-praxis think-piece presents some wry musings from recent experience in Uganda attempting to bridge the research-practice interface and share research findings in the context of small African towns. It is written from the perspective of a recent doctoral graduate in a light-hearted but enquiring manner, with sometimes humorous, sometimes frustrated, reflections on the ethical/practica
Abstract in Chinese年韩国总统选举中, 获胜候选人所属的政党几年前还毫无机会，但竞选角逐为何如此激烈？我们将选举置于民主和反民主力量的较量的背景中考察就能得到答案。反民主势力通过玩世不恭地诋毁政治来竞逐权力。对这种玩世不恭情绪如何在2016到2022年期间——但同时也在更深远的历史背景之下——如何演进的考察既表明了这次大选的利害攸关之处，也揭示了反民主力量的代表人物用以制造出选票差距的方法。Why was South Korea’s 2022 presidential election so close, when only a few years prior the party of the winning candidate had been out of contention? The answer can be found by situating the election against a battle between democratic and anti-democratic forces. Anti-democratic forces cynically bid for power by denigrating politics. An examination of how this cynical sensibility developed, from 2
