Summary Ribonucleotide reductases (RNRs) reduce ribonucleotides to deoxyribonucleotides. Their overall activity is stimulated by ATP and downregulated by dATP via a genetically mobile ATP cone domain mediating the formation of oligomeric complexes with varying quaternary structures. The crystal structure and solution X-ray scattering data of a novel dATP-induced homotetramer of the Pseudomonas aer

Pupil dilation indexes cognitive events of behavioral relevance, like the storage of information to memory and the deployment of attention. Yet, given the slow temporal response of the pupil dilation, it is not known from previous studies whether the pupil can index cognitive events in the short time scale of ∼100 ms. Here we measured the size of the pupil in the Attentional Blink (AB) experiment,

Jupiter's core is generally assumed to have formed beyond the snow line. Here we consider an alternative scenario that Jupiter's core may have accumulated in the innermost part of the protoplanetary disc. A growing body of research suggests that small particles ('pebbles') continually drift inward through the disc. If a fraction of drifting pebbles is trapped at the inner edge of the disc, several

AIMS: Vitamin B12 deficiency could be associated with cardiovascular autonomic neuropathy (CAN) in diabetes patients. We aim to investigate the association between serum levels of vitamin B12 and CAN in type 2 diabetes patients.METHODS: 469 ambulatory type 2 diabetes patients (mean diabetes duration 10.0years (IQR 5.0;17.0), mean age 59.0years (SD 11.6), 63% men, mean B12 289.0pmol/l (IQR 217;390)

OBJECTIVE: To evaluate the effect of group-based diabetes dialogue meetings (DDMs) on diabetes distress, perceived competence and glycaemic control.METHODS: Patients with type 1 diabetes (T1D) were invited to DDMs with peers and healthcare professionals. The impact of participation was evaluated by change in diabetes distress measured by Problem Areas in Diabetes (PAID), diabetes competence measur

BACKGROUND: Historically, intensive insulin therapy for type 1 diabetes (T1D) has improved glycemic control at the risk of adverse weight gain. The impact of continuous subcutaneous insulin infusion therapy (CSII) on weight in the current era remains unknown. We assessed changes in hemoglobin A1c (HbA1c) and weight in adults with T1D transitioning to CSII at 2 diabetes centers in Denmark and the U

The close relationship between young children’s living conditions and their healthlater in life is well documented and a safe and healthy environment during earlychildhood promotes cognitive functions and social development during the wholelifespan. Becoming a parent is a major life transition and it is sometimes described as a stressful and vulnerable time involving changes to lifestyle and routi

The prescriptive approach to crisis communication strategy (CCS) selection has long been criticized for lack of flexibility and adaptability. To address this issue, this study proposes an emergent approach to strategy formulation by focusing on contextual impacts on social media crises and their implications for CCS. An online discussion on Sina Weibo, a Chinese microblogging platform, about a hig

In this chapter we investigate the effects of video surveillance (CCTV) as reported in the extant research literature. We identify several gaps in this research and identify a number of additional potential benefits of video surveillance that have yet to be addressed by academic research. We also highlight the shift from analog to digital surveillance platforms in the past two decades, which has i

AIMS AND OBJECTIVES: To investigate the experience and personal impact of a group leadership course for child healthcare nurses.BACKGROUND: During their child's first year, all parents in Sweden are invited to participate in parental groups within the child health service; however, only 49% choose to participate. Despite extensive experience, child healthcare nurses find managing parental groups c

Ninety-nine per cent of all parents visit child healthcare centres (CHCs) andall parents in Sweden are invited to parental groups organized by the childhealth service (CHS) during their child’s first year, but only 40% choose toattend. The overall aim of this thesis was to elucidate the group-based earlyparental support provided by the Swedish CHS from the perspective of CHCnurses and parents. A t

Background: In many parts of the world, roadsides are regularly managed for traffic-safety reasons. Hence, there are similarities between roadsides and certain other managed habitats, such as wooded pastures and mown or grazed grasslands. In contrast to roadsides, the latter habitats have declined rapidly in Europe during the last century, and today only a fraction of their former extent remains.

Research on returns policies is scarce and inconclusive. This study is a first attempt to empirically analyze and describe the effects of returns policies on consumer behavior and the moderating effects of the policies on profitability. The method involves analyzing the transactional data of a Swedish online fashion retailer. The results of the regression analyses show that with a lenient returns

PurposeThe aim of the study is to understand how meaning is assigned to online searching by viewing it as a mundane, yet often invisible, activity of everyday life and an integrated part of various social practices.Design/methodology/approachSearching is investigated with a sociomaterial approach with a starting point in information searching as entangled across practices and material arrangements