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Joachim Koester: In the Face of Overwhelming Forces
Joachim Koester: Blueproject Foundation
Lots of flickering happening in Joachim Koester’s Message from Andrée
Joachim Koester: Stills Edinburgh
Joachim Koester, From the Secret Garden of Sleep
Geant4-aided Quantum State Selective Decay Spectroscopy of 213Ra
Utilizing the excellent mass resolving power of SHIPTRAP and the charged-particle-g multicoincidence setup TASISpec, the decay path of the 213Ra ground state can be exclusively studied. Based on virtual experiments with Geant4 it is possible to refine the a-branching ratios of the 213Ra ground state as well as g-ray branching ratios in the 209Rn daughter. The present study provides a proof of conc
Role Of The Delta Resonance In The Population Of Excited States In High-Energy Reactions
The 54Fe nucleus was populated from a 56Fe beam with an energy of E=A=500 MeV. The internal decay of the 10+ metastable state via g-ray emission was observed. The structure of this isomeric state has to involve at least four unpaired nucleons, therefore it cannot be populated in a simple two-neutron removal reaction from the ground state of 56Fe, and we suggest that it was populated via the decay
Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2
Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
A series of racemic aryl-substituted phenylalanines was synthesized and evaluated in vitro at recombinant rat GluA1-3, at GluK1-3, and at native AMPA receptors. The individual enantiomers of two target compounds, (RS)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid 37 and (RS)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid 38, were characterized. (S)-37 and (R)-38 were id
Acetylcholine-binding protein engineered to mimic the alpha4- alpha 4 binding pocket in alpha 4beta2 nicotinic acetylcholine receptors reveals interface specific interactions important for binding and activity
L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain
Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3, 4-dihydro-2 H-1, 2, 4-benzothiadiazine 1, 1-dioxide scaffold
Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors : unique role of halogen bonding revealed
The α4β2 subtype of the nicotinic acetylcholine receptor has been pursued as a drug target for treatment of psychiatric and neurodegenerative disorders and smoking cessation aids for decades. Still, a thorough understanding of structure-function relationships of α4β2 agonists is lacking. Using binding experiments, electrophysiology and x-ray crystallography we have investigated a consecutive serie
Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within the dimer interface of the LBD (ligand-binding domain) and stabilize the agonist-bound conformation slowing receptor desensitization and/or deactivation. In the present study, we employ isothermal titr
Measurement of the inclusive isolated prompt photon cross section in pp collisions at s=8TeV with the ATLAS detector
Abstract: A measurement of the cross section for the inclusive production of isolated prompt photons in proton-proton collisions at a centre-of-mass energy of s=8 TeV is presented. The measurement covers the pseudorapidity ranges |ηγ | < 1.37 and 1.56 ≤ |ηγ | < 2.37 in the transverse energy range 25 < ET γ < 1500 GeV. The results are based on an integrated luminosity of 20.2 fb−1, recorded by the
Search for single production of vector-like quarks decaying into Wb in pp collisions at √s = 8 TeV with the ATLAS detector
A search for singly produced vector-like Q quarks, where Q can be either a T quark with charge + 2 / 3 or a Y quark with charge - 4 / 3 , is performed in proton–proton collisions recorded with the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 20.3 fb- 1 and was produced with a centre-of-mass energy of s=8 TeV. This analysis targets Q→ Wb decays where the W boson
Measurement of the double-differential high-mass Drell-Yan cross section in pp collisions at √s = 8 TeV with the ATLAS detector
This paper presents a measurement of the double-differential cross section for the Drell-Yan Z/γ∗ → ℓ+ℓ− and photon-induced γγ → ℓ+ℓ− processes where ℓ is an electron or muon. The measurement is performed for invariant masses of the lepton pairs, mℓℓ, between 116 GeV and 1500 GeV using a sample of 20.3 fb−1 of pp collisions data at centre-of-mass energy of s=8 TeV collected by the ATLAS detector a
Measurement of fiducial differential cross sections of gluon-fusion production of Higgs bosons decaying to WW ∗→eνμν with the ATLAS detector at √s=8 TeV
This paper describes a measurement of fiducial and differential cross sections of gluon-fusion Higgs boson production in the H → W W∗→ eνμν channel, using 20.3 fb−1 of proton-proton collision data. The data were produced at a centre-of-mass energy of s=8 TeV at the CERN Large Hadron Collider and recorded by the ATLAS detector in 2012. Cross sections are measured from the observed H→ W W∗→ eνμν sig