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A new beamline, Cassiopeia, at MAX II is about to come into operation. It consists of an energy-tunable station and four side stations intended for macromolecular crystallography. The X-ray source is a 3.5 T superconducting multipole wiggler installed in the 1.5 GeV MAX II storage ring. The energy-tunable station use grazing incidence Rh-coated silicon mirrors and an internally water-cooled Si(111
The decreased survival of von Willebrand factor (VWF) in plasma has been implicated as a mechanism in a subset of type 1 von Willebrand disease (VWD) patients. We have previously reported that the ratio of plasma levels of VWF and its propeptide (VWFpp) can be used to identify patients with reduced VWF survival. In this study, we report the assay of VWFpp and VWF:Ag in 19 individuals recruited fro
Objective- Two independent genome wide association studies for type 2 diabetes in Japanese have recently identified common variants in the KCNQ1 gene to be strongly associated with type 2 diabetes. Here we studied whether a common variant in KCNQ1 would influence BMI, insulin secretion and action and predict future type 2 diabetes in subjects from Sweden and Finland. Research design and methods- R
The aim of this study was to investigate ethnic differences in different aspects of social participation in Malmö, Sweden. The public health survey in Malmö 1994 is a cross-sectional study. A total of 5600 randomly chosen individuals aged 20–80 years were asked to complete a postal questionnaire. The participation rate was 71%. The population was divided into categories born in Sweden, Denmark/Nor
The role of NMDA mechanisms in spinal pathways mediating acute nociceptive input to the somatosensory cortex is not clear. In this study, the effect of NMDA-antagonists on nociceptive C fibre transmission to the primary somatosensory cortex (SI) was investigated. Cortical field potentials evoked by CO2-laser stimulation of the skin were recorded in the halothane/nitrous oxide anaesthetized rat. T
Protein microarrays are powerful tools to quantify and characterize proteins in multiplex assays. They have great potential within clinical diagnostics and prognostics, as they minimize consumption of both analyte and biological sample. Assays that do not require labeling of the biological specimen, henceforth called label-free, are vital for ease of clinical sample processing. Here, we evaluate t
In the present study, entropy generation in rectangular cavities with the same area but different aspect ratios is numerically investigated. The vertical walls of the cavities are at different constant temperatures while the horizontal walls are adiabatic. Heat transfer between vertical walls occurs by laminar natural convection. Based on the obtained dimensionless velocity and temperature values,
Many breeding attempts in birds do not result in any fledged young due to predation on eggs or young. Consequently, the influence of time constraints on reproductive decisions are integrated parts of the reproductive behaviour of birds breeding within short, seasonal climate zones. In this study. I mimicked nest predation by removing blue tit (Parus caeruleus) clutches shortly after completion. Ar
Objective To investigate the basic pharmacodynamic properties of teicoplanin in vitro for Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium. Methods The following experiments were performed: (1) bacterial killing by teicoplanin at different concentrations; (2) bacterial killing by teicoplanin at 8 x MIC against the same strains with inocula of 5x10(3), 5x10(5) and 5x10(7)
From 1960 to 1980 and between 1987 and 1994 the whole-body content of 17Cs, and when possible also 134Cs, was measured in a group of subjects living in the city of Lund, Sweden (55.7 degrees N, 13.2 degrees E). The results have been analyzed to estimate the effective ecological half-time of fallout radiocesium in humans living in the area. The Lund area (The Province of Skane) was subjected to a d
Current approaches for treatment of late-stage breast cancer rarely result in a long-term cure. In part this is due to tumor stroma that prevents access of systemically or intratumorally applied therapeutics. We propose a stem cell gene therapy approach for controlled tumor stroma degradation that uses the pathophysiologic process of recruitment of inflammatory cells into the tumor. This approach
Catalytic activity of lipases (from Rhizopus arrhizus, Canadida rugosa, and Pseudomonas sp. was studied in organic media, mainly diisopropyl ether. The effect of water activity (a(w)) on V(max) showed that the enzyme activity in general increased with increasing amounts of water for the three enzymes. This was shown both for esterification and hydrolysis reactions catalyzed by R. arrhizus lipase.
Ten enzyme systems coding for 13 putative loci were studied in 12 European species of Sphagnum sect. Acutifolia (peat mosses). On average seven plants from each of 73 collections made throughout N Europe were analysed. Despite complex morphological variation, all species expressed unique allele combinations. Principal components and cluster analyses based on allele frequencies showed that sect. Ac
Objective: to gain a deeper understanding of both parents' experiences during the mother's stay in hospital for threat of an early delivery and eventual preterm birth. Design: explanatory design with separate interviews for mothers and fathers using the grounded theory method. Setting: University Hospital in southern Sweden. Participants: 17 mothers and six fathers, who had experienced a thr
After 50 years of its prediction, the highest-lying [2 0 2]3/2 orbit among the six Nilsson single-particle orbits originating from the sd shells in prolately deformed nuclei and the rotational band on this orbit were identified. The band members were observed in Al-25 at excitation energies of 6-7.5 MeV in a high-resolution Mg-25(He-3,t) charge-exchange reaction at 0degrees having a strong selecti
