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Sequencing of immunoglobulin germline gene loci is a challenging process, e.g. due to their repetitiveness and complexity, hence limiting the insight in the germline gene repertoire of humans and other species. Through next generation sequencing technology, it is possible to generate immunoglobulin transcript data sets large enough to computationally infer the germline genes from which the transcr

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) carries risk of sudden death. We hypothesize that the S-wave angle differentiates ARVD/C with otherwise normal electrocardiograms from controls. Materials and methods: All patients met Task Force 2010 definite ARVD/C criteria. ARVD/C patients without Task Force depolarization/repolarization criteria (−ECG) were compared

Fundamental to regulatory guidelines is to identify chemicals that are implicated with adverse human health effects and inform public health risk assessors about “acceptable ranges” of such environmental exposures (e.g., from consumer products and pesticides). The process is made more difficult when accounting for complex human exposures to multiple environmental chemicals. Herein we propose a new

Cell line-based proteomics studies are susceptible to intrinsic biological variation that contributes to increasing false positive claims; most of the methods that follow these changes offer a limited understanding of the biological system. We applied a quantitative proteomic strategy (iTRAQ) to detect intrinsic protein variation across SH-SY5Y cell culture replicates. More than 95% of the quantif

Results of a search for gluino pair production with subsequent R-parity-violating decays to quarks are presented. This search uses 36.1 fb−1 of data collected by the ATLAS detector in proton–proton collisions with a centre-of-mass energy of s=13 TeV at the LHC. The analysis is performed using requirements on the number of jets and the number of jets tagged as containing a b-hadron as well as a top

We propose a formulation of the Network Design Problem (NDP) to support transport planners in dealing with multimodal networks in contexts characterised by different (and sometimes conflicting) interests and limited resources in a transparent way. We expect that the implementation of the method can increase the acceptability of transport schemes. The proposed formulation expands the scope of tradi

Over the past decade, the number of ongoing bike-sharing programs has remarkably risen. In this framework, operators need appropriate methodologies to support them in optimizing the allocation of their resources to globally enhance the bike-sharing program, even without massive and costly interventions on the existing configuration of the system. In this paper, we propose an optimization model abl

Given the growing importance of bike-sharing systems nowadays, in this paper we suggest an alternative approach to mitigate the most crucial problem related to them: the imbalance of bicycles between zones owing to one-way trips. In particular, we focus on the emerging free-floating systems, where bikes can be delivered or picked-up almost everywhere in the network and not just at dedicated dockin

In the transportation literature, equity has been and is still used with a variety of meanings and purposes. Traditionally, equity has been considered in strategic transport planning but very few works have been addressing it in a quantitative way, detailing how to explicitly consider it at a transportation design level (tactical and/or operational) focusing on the consequent social role of transp

Free-floating bike sharing systems are an emerging new generation of bike rentals, that eliminates the need for specific stations and allows to leave a bicycle (almost) everywhere in the network. Although free-floating bikes allow much greater spontaneity and flexibility for the user, they need additional operational challenges especially in facing the bike relocation process. Then, we suggest a m

In transportation planning, solutions designed to meet objectives of equity and social inclusion have to be achieved. From this standpoint, most of Network Design Problem (NDP) models aim at identifying the optimal layout of transportation networks by deterministic bi-level problems formulation to reflect the different goals of at least two decision makers (the network users and the planner). Cons

Automatic composition of geospatial web services increases the possibility of taking full advantage of spatial data and processing capabilities that have been published over the internet. In this paper, a multi-agent artificial intelligence (AI) planning solution was proposed, which works within the geoportal architecture and enables the geoportal to compose semantically annotated Open Geospatial

This article examines irregular South‐South migration from China to Ghana, and the role it played in transforming livelihoods and broader developmental landscapes. It looks at the entry of approximately 50,000 Chinese migrants into the informal small‐scale gold mining sector from 2008‐2013. These migrants mainly hailed from Shanglin County in Guangxi Province. In Ghana, they formed mutually benefi

1. IntroductionThe demand for efficient oil-water separation is driven by the tightening of discharge limits for e.g. produced water in the oil and gas industry, process water in the petrochemical industry and bilge water in the marine industry. The global produced water production alone is over 71 billion bbl/a – 8.4 billion m3/a [1]. Among the different technologies, particularly ultrafiltration

The global society has started a journey from using fossil-based raw material to the utilisation of climate-smart sustainable raw materials. Biorefineries have been identified as one of the backbones of the new bioeconomy using fermentation processes to convert biomass to biofuels and –chemicals and thus replacing the conventional C2/C3 chemistry with biotechnological processes. In current petro-c

This work addresses the assessment of ultrafiltration (UF) and nanofiltration (NF) for the treatment of a bleaching plant effluent (BPE) from aPortuguese sulphite pulp mill (Caima-Indústria de Celulose,S.A.) with the two-fold objective of water consumption minimization and by-products valorization. This is to be achieved through the recycling of UF/NF permeates as process water and the concentrati

The demand for water recovery in the industry is increasingly important partly due to water shortage and partly due to tightening of regulatory requirements. In this paper water recovery solutions for two challenging types of wastewater - oily and polyvinylchloride (PVC) wastewater - are presented. The first part of the presentation analyses the operation and performance of a membrane unit operate

IntroductionThe start of the 21st century is combined with the continuous replacement of classic C2/C3 chemistry with biological processes. This conversion process started at the end the 20th century and is combined with the integration of membrane processes as high selective and low energy consuming separation technologies in the production of fermentation based products. In fermentation based pr

1. IntroductionBoth the development of nowadays membrane technology and nutritive sweeteners started in the middle of the 20th century. The development of the asymmetric membranes using phase inversion was pioneered by Loeb and Sourirajan in the 1960-ies, while the discovery of glucose isomerase was a milestone in the commercialisation of high fructose corn syrup in the beginning of the 1970-ies.

Polysulfone (PSf) is a traditional material widely used for manufacturing microfiltration and ultrafiltration membranes by non-solvent induced phase separation (NIPS) process. However, the hydrophobic nature of PSf makes the membranes prone to protein fouling. In order to create non fouling surfaces and further decrease the pore size, the membrane pores can be modified by different strategies as a