Popular Abstract in Swedish De allra flesta människor har vid något tillfälle tagit ett läkemedel. Till exempel vaccineras nu för tiden alla svenska barn mot bland annat stelkramp. Vad nog de allra flesta däremot inte har gjort är att fundera på vad ett läkemedel är. Kanske sträcker man sig till att ha kollat upp ett läkemedel i FASS, och kanske får man då syn på en figur som består av streck och A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. In a series of 15 papers, we have tested, compared, and improved the most p

A scheme for lidar measurements of multicomponent gas mixtures in the mid-IR region using a newly developed fast-switching, frequency-agile optical parametric oscillator (OPO) system combined with multivariate statistical methods has been implemented and tested. The scheme adopted was able to predict the composition of the remote hydrocarbon gas mixture within the uncertainty of the pre-determined

Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson’s disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function a

This paper describes a VLSI implementation of V-BLAST detection for future multiple-input-multiple-output (MIMO) wireless communications. This design is implemented using a 0.35-μm 5-layer metal 3.3 V CMOS technology. For a 4-transmit and 4-receive antennas system using QPSK modulation scheme, a detecting throughput of 128 Mb/s can be achieved. Furthermore, it is shown that the implementation comp

Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. The baculovirus/insect cell system, which has a high expression rate and post-translational mashinery closely resemb

Commonly used definitions of plagiarism are misleading in that they seem to indicate that 1) plagiarism is associated with either intent or ignorance and that 2) the requirements for claiming ownership can be uniquely defined. However, the differences between coexisting socio-cultural contexts are large enough that a clear case of plagiarism in one context might even be considered as good practice

There are instruments that measure sexual function or sexual health for persons with RA, but since sexual health is a sensitive issue, the hypothesis is that it would be easier to have a standard questionnaire that could indicate the need for communication about sexual health issues instead of an extra questionnaire with more detailed questions on sexual health. The aim of the study is to find out