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The CRISPR/Cas9 system has emerged as a transformative tool in genome editing, playing a pivotal role in enabling precise genetic engineering. Achieving high on-target efficiency while minimizing off-target activity is critical for translating CRISPR/Cas9 into reliable experimental and therapeutic applications. Conventional off-target detection methods are labor-intensive and cost-prohibitive, lim

The glymphatic system facilitates cerebrospinal fluid (CSF)-interstitial fluid exchange and plays a key role in solute clearance and neurophysiological homeostasis. While dysfunction of this system has been shown in traumatic brain injury, stroke, meningitis, idiopathic normal pressure hydrocephalus and neurodegenerative diseases, direct measurement of glymphatic transport in humans remains elusiv

BACKGROUND AND OBJECTIVE: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-lactam dosing, but is often limited by availability. UV/VIS spectrophotometry can quantify drug levels in saline, and if those levels truly reflect plasma concentrations, it could

Who benefited from agricultural commercialization in colonial Africa? Using social tables for three African economies, we identify a small group of rural capitalists who captured disproportionate gains. We demonstrate how their strategies of accumulation varied across contexts and shaped divergent and often unequal development trajectories.

Municipalities shoulder the burden of creating business-friendly environments – managing infrastructure, navigating public resistance, and investing countless hours in smoothing the path for economic development. Yet, the rewards often flow elsewhere. Local taxes on economic activity offer a powerful solution. While a thriving local economy boosts budgets, different taxes shape municipal decision-

Background: This study evaluates deep learning (DL) using gene expression (GEX) and preoperatively available clinical data (PreopClinic) to predict sentinel lymph node macro-metastasis (SLNM), and explores their potential for guiding axillary surgery de-escalation and supporting prognostic assessment.Methods: We retrospectively included 6,836 clinically node-negative (cN0) T1-T2 patients with inva

Att sluta begå brott handlar inte enbart om förändrade handlingar, utan också om hur individer omformulerar vem de är. Denna avhandling analyserar hur unga personer med erfarenhet av kriminalitet konstruerar och förhandlar sina identiteter i berättelser om brottsdebut, fortsatt brottslighet och upphörande med brott. Avhandlingen behandlar tre centrala frågor: (1) Vilka innehållsmässiga komponenterIn this thesis I explore how young people with a criminal record choose to construct and negotiate their identities in narratives about debut offences, re-offending, and desistance. I address three key questions: (1) What content-related components are central to young people’s narratives of desistance? (2) What linguistic and cultural resources do young people draw on to present themselves as cre

Hemoglobin (Hb) can produce reactive oxygen species, including superoxide anions, which are intrinsically toxic. Superoxide dismutase (SOD) is present in red blood cells (RBCs) and provides important protection against such oxidative stress. Upon hemolysis, Hb becomes released from the RBCs and the normal protection systems involving SOD and catalase become very inefficient. In these instance

There has been active research in the development of new rigid biobased aromatic dicarboxylate monomers that can replace the widely used fossil-based dimethyl terephthalate in polyester production. In this work, a new biobased dicarboxylate monomer with a spiroacetal unit was synthesized from biobased vanillin and pentaerythritol, which aims to partially or completely replace the fossil-based

Durable and high-performing anion-exchange membranes (AEMs) are key components in alkaline water electrolyzers and fuel cells. As potentially more sustainable and cost-effective alternatives to proton exchange membrane (PEM)-based systems, AEM-based devices can operate without platinum-group metal catalysts or perfluorinated polymers. However, their broader practical implementation remains limited